|Increased plasma levels of the soluble Mer tyrosine kinase receptor in systemic lupus erythematosus relate to disease activity and nephritis|
|Wu, Jun1,4; Ekman, Carl1; Jonsen, Andreas2; Sturfelt, Gunnar2; Bengtsson, Anders A.2; Gottsater, Anders3; Lindblad, Bengt3; Lindqvist, Elisabet2; Saxne, Tore2; Dahlback, Bjorn1|
|刊名||ARTHRITIS RESEARCH & THERAPY|
|WOS标题词||Science & Technology|
|关键词[WOS]||EARLY RHEUMATOID-ARTHRITIS ; CRITICAL LIMB ISCHEMIA ; APOPTOTIC CELLS ; DENDRITIC CELLS ; TAM RECEPTORS ; CLEARANCE ; GAS6 ; PHAGOCYTOSIS ; AUTOIMMUNITY ; MACROPHAGES|
Introduction: Mer and Tyro3 are receptor tyrosine kinases important for the phagocytosis of apoptotic cells. Together with Axl, they constitute the TAM receptor family. These receptors can be shed from the cell membrane and their soluble extracellular regions can be found in plasma. The objective of this study was to elucidate whether the plasma levels of soluble Mer (sMer) and Tyro3 (sTyro3) were increased in systemic lupus erythematosis (SLE), rheumatoid arthritis (RA), or critical limb ischemia (CLI).
Methods: ELISA kits were used to test plasma concentrations in controls and in patients with SLE, RA or CLI.
Results: Increased levels of, in particular, sMer and, to some extent, sTyro3, were found in patients with SLE or RA, but not in patients with CLI. Patients with SLE demonstrated the highest sMer levels and there was a strong correlation to higher SLE disease activity score (SLEDAI). In contrast, in patients with RA, the sMer levels did not correlate with the disease activity score (DAS). In SLE, sMer levels were particularly high in those with lupus nephritis, patients who also had decreased C1q levels and increased titers of anti-DNA antibodies. After therapy, the plasma concentrations of sMer decreased in parallel to the decrease in SLEDAI score.
Conclusions: The plasma concentrations of sMer and sTyro3 were significantly increased in patients with active SLE and RA, suggesting the TAM receptor shedding was affected by these autoimmune diseases. In particular, sMer was increased in SLE, the plasma levels of sMer reflecting disease activity.
|资助机构||Swedish Research Council ; Medical Faculty at Lund University ; Osterlunds Foundation ; Greta and Johan Kock&prime ; s Foundation ; King Gustaf V&prime ; s 80th Birthday Foundation ; University Hospital Research Foundations ; Ernhold Lundstrom Foundation ; Albert Pahlsson Foundation ; Hulda Ahlmroth Foundation ; Swedish Rheumatism Association ; Swedish Society of Medicine ; Foundation of the National Board of Health and Welfare ; Swedish Government under the LUA/ALF agreement|
|作者单位||1.Lund Univ, Dept Lab Med, Sect Clin Chem, Wallenberg Lab,Skane Univ Hosp, SE-20502 Malmo, Sweden|
2.Lund Univ, Dept Clin Sci, Rheumatol Sect, Skane Univ Hosp, SE-22185 Lund, Sweden
3.Lund Univ, Dept Clin Sci, Vasc Ctr, Skane Univ Hosp, SE-20502 Malmo, Sweden
4.Peking Univ, Dept Lab Med, Peoples Hosp, Beijing 100044, Peoples R China
|Wu, Jun,Ekman, Carl,Jonsen, Andreas,et al. Increased plasma levels of the soluble Mer tyrosine kinase receptor in systemic lupus erythematosus relate to disease activity and nephritis[J]. ARTHRITIS RESEARCH & THERAPY,2011,13(2).|
|APA||Wu, Jun.,Ekman, Carl.,Jonsen, Andreas.,Sturfelt, Gunnar.,Bengtsson, Anders A..,...&Dahlback, Bjorn.(2011).Increased plasma levels of the soluble Mer tyrosine kinase receptor in systemic lupus erythematosus relate to disease activity and nephritis.ARTHRITIS RESEARCH & THERAPY,13(2).|
|MLA||Wu, Jun,et al."Increased plasma levels of the soluble Mer tyrosine kinase receptor in systemic lupus erythematosus relate to disease activity and nephritis".ARTHRITIS RESEARCH & THERAPY 13.2(2011).|