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学科主题: 基础医学
题名:
Clinical Implications for Girdin Protein Expression in Breast Cancer
作者: Ling, Yun1; Jiang, Ping1; Cui, Su-Ping1; Ren, Ya-Li2; Zhu, Sai-Nan3; Yang, Jing-Ping1; Du, Juan1; Zhang, Yan1; Liu, Jian-Ying1; Zhang, Bo1
关键词: Girdin ; CerbB2 ; Breast cancer
刊名: CANCER INVESTIGATION
发表日期: 2011-07-01
DOI: 10.3109/07357907.2011.568568
卷: 29, 期:6, 页:405-410
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: ACTIN-BINDING PROTEIN ; CARCINOMA IN-SITU ; PROGESTERONE-RECEPTOR ; ESTROGEN-RECEPTOR ; CELLS ; ACTIVATION ; MOTILITY ; TARGETS ; FAMILY ; ALPHA
英文摘要:

Girdin is highly expressed in breast carcinomas. Suppression of Girdin inhibited breast cancer cell migration. However, the clinical implications of Girdin as a marker are still unclear. Here we examined 80 breast cancer specimens using immunohistochemistry. Overall, positive Girdin staining was 41.25% in all of the cases. Girdin was strongly expressed in tumors of CerbB2-positive breast cancers (p < .05). Cases with both CerbB2- and Girdin-positive expression had a higher histological grade than the others. These findings indicated the closed relationship between breast cancer progression and Girdin expression. Girdin together with CerbB2 might be a new potential marker for breast cancers.

语种: 英语
所属项目编号: 30570691 ; 81072172 ; 20100470170
项目资助者: National Natural Science Foundation of China ; China Postdoctoral Science Foundation
WOS记录号: WOS:000291353100004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64370
Appears in Collections:基础医学院_病理学系_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 1, Lab Electron Microscopy, Beijing 100191, Peoples R China
3.Peking Univ, Hosp 1, Dept Biostat, Beijing 100191, Peoples R China

Recommended Citation:
Ling, Yun,Jiang, Ping,Cui, Su-Ping,et al. Clinical Implications for Girdin Protein Expression in Breast Cancer[J]. CANCER INVESTIGATION,2011,29(6):405-410.
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