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学科主题: 药学
题名:
The tandem reaction combining radical and ionic processes: an efficient approach to substituted 3,4-dihydroquinolin-2-ones
作者: Zhou, Wang1; Zhang, Liangren1; Jiao, Ning1,2
刊名: TETRAHEDRON
发表日期: 2009-03-07
DOI: 10.1016/j.tet.2009.01.027
卷: 65, 期:10, 页:1982-1987
收录类别: SCI ; IC ; CCR
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: ALKYL IODIDES ; RING LACTONES ; CYCLIZATION ; ARYL ; PALLADIUM ; LACTAMS ; INDOLONES ; CYCLOCARBONYLATION ; 4-ARYL-2-QUINOLONES ; CONDENSATIONS
英文摘要:

3,4-Dihydroquinolin-2-ones are of great importance in the areas of pharmaceuticals. However, the direct intramolecular radical cyclizations of the corresponding amide compounds favor 5-exo products 2. Reports on the radical cyclization reactions producing 3,4-dihydroquinolin-2-one derivatives are limited. Herein, an efficient tandem reaction combining radical and ionic processes was developed, which provides a practical synthetic strategy for the synthesis of substituted 3,4-dihydroquinolin-2-ones from simple and readily available precursors under neutral reaction conditions. (C) 2009 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 20702002 ; 20872003 ; 20070001808
项目资助者: Peking University and National Science Foundation of China ; Ph.D. Programs Foundation of Ministry of Education of China
WOS记录号: WOS:000263945800007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64373
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Chinese Acad Sci, State Key Lab Organomet Chem, Shanghai 200032, Peoples R China

Recommended Citation:
Zhou, Wang,Zhang, Liangren,Jiao, Ning. The tandem reaction combining radical and ionic processes: an efficient approach to substituted 3,4-dihydroquinolin-2-ones[J]. TETRAHEDRON,2009,65(10):1982-1987.
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