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学科主题: 基础医学
题名:
Distinct responses of DREAM to electroacupuncture stimulation with different frequencies during physiological and inflammatory conditions in rats
作者: Li, Yi; Zhang, Ying; Han, Ji-Sheng; Wang, Yun1
关键词: DREAM ; preprodynorphin ; electroacupuncture ; frequency ; spinal dorsal horn ; inflammation
刊名: NEUROCHEMICAL RESEARCH
发表日期: 2008-10-01
DOI: 10.1007/s11064-008-9686-9
卷: 33, 期:10, 页:2070-2077
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Neurosciences
研究领域[WOS]: Biochemistry & Molecular Biology ; Neurosciences & Neurology
关键词[WOS]: TRANSCRIPTIONAL REPRESSOR ; POTASSIUM CHANNELS ; BRAIN ; PAIN ; MODULATION ; EXPRESSION ; ELEMENT ; BINDING ; PROTEIN ; GENES
英文摘要:

Our previous results indicated that dynorphin in the spinal dorsal horn mediates the analgesic effect of high frequency electroacupuncture stimulation (EAS). Here we report that the transcriptional repressor downstream regulatory element antagonist modulator (DREAM) of dynorphin precursor-preprodynorphin (PPD) may participate in this process. In normal rats, 100 Hz, but not 2 Hz EAS triggered the nuclear export and membrane translocation of DREAM concomitantly with the upregulation of PPD mRNA in the dorsal horn. In inflammatory rats, both 2 and 100 Hz EAS alleviated thermal and mechanical hypersensitivity and caused the nuclear export and membrane translocation of DREAM, but only 100 Hz EAS enhanced the mRNA level of PPD and DREAM. These results suggest the role of DREAM in the dorsal horn in the regulation of PPD gene expression by EAS is frequency dependent, and DREAM may exert different roles in different frequency EAS under physiological and inflammatory conditions.

语种: 英语
所属项目编号: 30330230 ; 30470550 ; 5052019 ; 2001-182 ; 04-05JP04
项目资助者: National Natural Science Foundation of China ; Natural Science Foundation ; Ministry of Education, China ; State Administration of Traditional Chinese Medicine of the People&prime ; s Republic of China
WOS记录号: WOS:000259190900021
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64378
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: 1.Peking Univ, Neurosci Res Inst, Beijing 100083, Peoples R China
2.Peking Univ, Minist Educ Hlth, Key Lab Neurosci, Dept Neurobiol, Beijing 100083, Peoples R China

Recommended Citation:
Li, Yi,Zhang, Ying,Han, Ji-Sheng,et al. Distinct responses of DREAM to electroacupuncture stimulation with different frequencies during physiological and inflammatory conditions in rats[J]. NEUROCHEMICAL RESEARCH,2008,33(10):2070-2077.
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