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学科主题基础医学
Distinct responses of DREAM to electroacupuncture stimulation with different frequencies during physiological and inflammatory conditions in rats
Li, Yi; Zhang, Ying; Han, Ji-Sheng; Wang, Yun1
关键词Dream Preprodynorphin Electroacupuncture Frequency Spinal Dorsal Horn Inflammation
刊名NEUROCHEMICAL RESEARCH
2008-10-01
DOI10.1007/s11064-008-9686-9
33期:10页:2070-2077
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Neurosciences
研究领域[WOS]Biochemistry & Molecular Biology ; Neurosciences & Neurology
关键词[WOS]TRANSCRIPTIONAL REPRESSOR ; POTASSIUM CHANNELS ; BRAIN ; PAIN ; MODULATION ; EXPRESSION ; ELEMENT ; BINDING ; PROTEIN ; GENES
英文摘要

Our previous results indicated that dynorphin in the spinal dorsal horn mediates the analgesic effect of high frequency electroacupuncture stimulation (EAS). Here we report that the transcriptional repressor downstream regulatory element antagonist modulator (DREAM) of dynorphin precursor-preprodynorphin (PPD) may participate in this process. In normal rats, 100 Hz, but not 2 Hz EAS triggered the nuclear export and membrane translocation of DREAM concomitantly with the upregulation of PPD mRNA in the dorsal horn. In inflammatory rats, both 2 and 100 Hz EAS alleviated thermal and mechanical hypersensitivity and caused the nuclear export and membrane translocation of DREAM, but only 100 Hz EAS enhanced the mRNA level of PPD and DREAM. These results suggest the role of DREAM in the dorsal horn in the regulation of PPD gene expression by EAS is frequency dependent, and DREAM may exert different roles in different frequency EAS under physiological and inflammatory conditions.

语种英语
WOS记录号WOS:000259190900021
项目编号30330230 ; 30470550 ; 5052019 ; 2001-182 ; 04-05JP04
资助机构National Natural Science Foundation of China ; Natural Science Foundation ; Ministry of Education, China ; State Administration of Traditional Chinese Medicine of the People&prime ; s Republic of China
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64378
专题北京大学基础医学院_神经生物学系
作者单位1.Peking Univ, Neurosci Res Inst, Beijing 100083, Peoples R China
2.Peking Univ, Minist Educ Hlth, Key Lab Neurosci, Dept Neurobiol, Beijing 100083, Peoples R China
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GB/T 7714
Li, Yi,Zhang, Ying,Han, Ji-Sheng,et al. Distinct responses of DREAM to electroacupuncture stimulation with different frequencies during physiological and inflammatory conditions in rats[J]. NEUROCHEMICAL RESEARCH,2008,33(10):2070-2077.
APA Li, Yi,Zhang, Ying,Han, Ji-Sheng,&Wang, Yun.(2008).Distinct responses of DREAM to electroacupuncture stimulation with different frequencies during physiological and inflammatory conditions in rats.NEUROCHEMICAL RESEARCH,33(10),2070-2077.
MLA Li, Yi,et al."Distinct responses of DREAM to electroacupuncture stimulation with different frequencies during physiological and inflammatory conditions in rats".NEUROCHEMICAL RESEARCH 33.10(2008):2070-2077.
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