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学科主题: 基础医学
题名:
Influence of CYP3A5 polymorphism on tacrolimus blood concentrations in renal transplant patients
作者: Nie, XM; Gui, R; Zhao, HS; Ma, DL; Li, DQ; Yuan, H; Huang, ZF
关键词: tacrolimus ; gene polymorphism ; CYP3A5
刊名: JOURNAL OF CENTRAL SOUTH UNIVERSITY OF TECHNOLOGY
发表日期: 2005-10-01
卷: suppl.1, 期:0, 页:310-312
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Metallurgy & Metallurgical Engineering
研究领域[WOS]: Metallurgy & Metallurgical Engineering
英文摘要:

Objective Tacrolimus is an immunosuppressive drug with narrow therapeutic range and wide interindividual variation in its pharmacokinetics. Tacrolimus is a substrate of cytochrome P450 (CYP) 3A5. The aim of this study was to evaluate whether the A6986G polymorphism is associated with tacrolimus concentration /dose ratio. Methods Fifty-two Chinese renal transplant patients were enrolled in this study. Their body weight, dosage and concentration of tacrolimus were observed. CYP3A5 genotype was determined by polymerase chain reaction followed by restriction fragment length polymorphism analysis. Results A significant association was found between tacrolimus levels per dose/kg/d and CYP3A5 gene A6986G polymorphism(P<0.001). The CYP3A5 * 3 * 3 patients have a significantly higher tacrolimus level/dose than CYP3A5 * 1 * 1 and CYP3A5 * 1 * 3. Conclusions CYP3A5 gene A6986G polymorphism is associated with tacrolimus pharmacokinetics and dose requirements. Pharmacogenetic methods could be employed prospectively to help the dose selection and to individualize immunosuppressive therapy according to the result.

语种: 英语
WOS记录号: WOS:000234422700061
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64383
Appears in Collections:基础医学院_北京大学人类疾病基因研究中心_期刊论文

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作者单位: 1.Cent S Univ, Xiangya Hosp 3, Changsha 410013, Peoples R China
2.Peking Univ, Ctr Human Dis Genom, Beijing 100083, Peoples R China

Recommended Citation:
Nie, XM,Gui, R,Zhao, HS,et al. Influence of CYP3A5 polymorphism on tacrolimus blood concentrations in renal transplant patients[J]. JOURNAL OF CENTRAL SOUTH UNIVERSITY OF TECHNOLOGY,2005,suppl.1(0):310-312.
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