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学科主题: 临床医学
题名:
Prognostic value of apoptosis and apoptosis-associated proteins in salivary gland adenoid cystic carcinoma
作者: Jia, L; Esguerra, RL; Tang, XF; Yin, HF; Sakamoto, K; Okada, N; Takagi, M
关键词: apoptosis ; bcl-2 ; cumulative survival ; mdm2 ; p53 ; salivary gland adenoid cystic carcinoma
刊名: PATHOLOGY INTERNATIONAL
发表日期: 2004-04-01
卷: 54, 期:4, 页:217-223
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pathology
研究领域[WOS]: Pathology
关键词[WOS]: SQUAMOUS-CELL CARCINOMAS ; TUMOR-SUPPRESSOR GENE ; P53 PROTEIN ; EXPRESSION ; BCL-2 ; MDM2 ; FEATURES ; TONGUE ; NECK ; HEAD
英文摘要:

The purpose of the present study was to investigate the level of apoptosis and expressions of p53, mdm2 and bcl-2 proteins in salivary gland adenoid cystic carcinoma (ACC) to determine potential relationships among apoptosis, apoptosis-associated proteins and clinical cumulative survival. Thirty-nine formalin-fixed, paraffin-embedded cases, cribriform (17), tubular (13) and solid (9), were studied by immunohistochemistry. Apoptosis detection and analysis were determined by terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick-end labeling (TUNEL). There was an inverse significance between the apoptotic index (AI) and bcl-2 expression (P = 0.018), whereas no correlation was found between the AI and either p53 or mdm2 expression (P = 0.416 and P = 0.456). Co-expression of p53 and mdm2 was found in 22 cases (P = 0.037). Patients with p53-positive tumors had a worse prognosis than those with p53-negative tumors (P = 0.014). Patients with a high AI had a better cumulative survival than patients with a low AI (P = 0.038). The present study suggests that p53 expression and AI can be useful as prognostic values; bcl-2 protein plays a role in the down-regulation of apoptosis and is also potentially useful as a prognostic parameter in salivary gland ACC.

语种: 英语
WOS记录号: WOS:000220174800001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64387
Appears in Collections:北京大学第一临床医学院_病理科_期刊论文

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作者单位: 1.Tokyo Med & Dent Univ, Grad Sch, Div Oral Hlth Sci, Dept Oral Restitut,Bunkyo Ku, Tokyo 1138549, Japan
2.Tokyo Med & Dent Univ, Dent Hosp, Dept Diagnost Oral Pathol, Tokyo, Japan
3.Jilin Univ, Sch Stomatol, Dept Oral Pathol, Changchun 130023, Peoples R China
4.Peking Univ, Hosp 1, Dept Pathol, Beijing 100871, Peoples R China

Recommended Citation:
Jia, L,Esguerra, RL,Tang, XF,et al. Prognostic value of apoptosis and apoptosis-associated proteins in salivary gland adenoid cystic carcinoma[J]. PATHOLOGY INTERNATIONAL,2004,54(4):217-223.
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