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学科主题: 药学
题名:
Development of a pulmonary peptide delivery system using porous nanoparticle-aggregate particles for systemic application
作者: Yang, Likai1; Luo, Jing1; Shi, Sanjun1; Zhang, Qiang2; Sun, Xun1; Zhang, Zhirong1; Gong, Tao1,3
关键词: Pulmonary drug delivery ; Nanostructured lipid carriers ; Hydrophobic ion pair complex ; Spray freeze drying
刊名: INTERNATIONAL JOURNAL OF PHARMACEUTICS
发表日期: 2013-07-15
DOI: 10.1016/j.ijpharm.2013.04.077
卷: 451, 期:1-2, 页:104-111
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: SOLID LIPID NANOPARTICLES ; ACUTE ABDOMINAL HYPERTENSION ; DRUG-DELIVERY ; PROTECTIVE ACTION ; HYPOXIC ISCHEMIA ; CARRIERS ; INSULIN ; REPERFUSION ; PROTEINS ; COMPLEX
英文摘要:

As a non-invasive administration route, pulmonary peptide delivery for systemic application has shown great promise. However, many barriers exist that prevent effective peptide delivery. The use of porous nanoparticle-aggregate particles (PNAPs) is an excellent option because of their proper aerodynamic size and maximal deposition. However, in most cases, the spray drying heating process for PNAPs has been challenging in regard to maintaining peptide stability and activity. To overcome these issues, we developed a spray freeze-drying method for PNAP preparation. To solve the low entrapment efficiency problem of nanostructured lipid carriers, we used hydrophobic ion pair complexes to increase the lipophilicity of the peptide, thus increasing entrapment efficiency and drug loading. Here, we used a model peptide, octreotide acetate, for PNAP preparation, which has a high entrapment efficiency (>95%) and proper aerodynamic size (similar to 3 mu m). In addition, after intrapulmonary administration, we evaluated the pharmacokinetics and pharmacodynamics in a rat preventive hepatic ischemia-reperfusion injury model. Our in vivo data showed significantly increased area under the curve and improved plasma aspartate amino-transferase levels for our PNAP intrapulmonary delivery system vs. the clinically used octreotide acetate delivery via subcutaneous injection. Together, PNAPs may have great potential for carrying peptide drugs for pulmonary delivery. (c) 2013 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 2009CB930300 ; 2012CB724002 ; 2011ZX09501-001-01
项目资助者: National Basic Research Programs of China (973 program) ; program for National S &amp ; T Major project of China
WOS记录号: WOS:000320587100013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64392
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Sichuan Univ, West China Sch Pharm, Minist Educ, Key Lab Drug Targeting & Drug Delivery Syst, Chengdu 610041, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing, Peoples R China
3.Tianjin Inst Pharmaceut Res, State Key Lab Drug Delivery Technol & Pharmacokin, Tianjin, Peoples R China

Recommended Citation:
Yang, Likai,Luo, Jing,Shi, Sanjun,et al. Development of a pulmonary peptide delivery system using porous nanoparticle-aggregate particles for systemic application[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2013,451(1-2):104-111.
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