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Icariin Ameliorates Streptozotocin-Induced Diabetic Retinopathy in Vitro and in Vivo
Xin, Hua1; Zhou, Feng2; Liu, Tao2; Li, Guang-Yong2; Liu, Jing2; Gao, Zhe-Zhu2; Bai, Guang-Yi2; Lu, Hong1; Xin, Zhong-Cheng2
关键词icariin streptozotocin diabetes retina diabetic retinopathy
刊名INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2012
DOI10.3390/ijms13010866
13期:1页:866-878
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary
研究领域[WOS]Chemistry
关键词[WOS]ERECTILE FUNCTION ; GROWTH-FACTOR ; RATS ; EXPRESSION ; CELLS ; COMPLICATIONS ; EPIDEMIOLOGY ; DYSFUNCTION ; BREAKDOWN ; DISEASE
英文摘要

This study investigated the effect of Icariin (ICA) supplementation on diabetic retinopathy (DR) in a streptozotocin-induced diabetic rat model system. Fifty Sprague Dawley rats were randomly distributed into a control group and a streptozotocin-induced diabetes group. Diabetic rats were randomly divided into two groups; one group received ICA 5 mg/kg/day for 12 weeks by oral gavage; the other group received saline gavage as a placebo. Retinal morphological changes, endothelial markers (RECA), collagen IV (Col-IV), vascular endothelial growth factor (VEGF), and neuropathic changes (Thy-1 and Brn3a expression) of the retinal ganglion cells (RGCs) were investigated. The effects of ICA at various concentrations (0, 10(1), 10(2), 10(3) nmol/mL) on neurite growth were investigated also in retinal ganglion cells (RGC) cultured from both diabetic and normal animals. Numerous pathological changes (deceased expression of RECA, VEGF, Thy-1, and Brn3a as well as decreased Collagen IV and Muller cell content) were noted in the retinal vessels of diabetic rats; these changes were attenuated in diabetic animals that received ICA. ICA enhanced neurite growth in RGC from both normal rats and diabetic rats in a dose dependent fashion. ICA may be useful in the treatment of diabetic retinopathy. Further investigations are indicated.

语种英语
WOS记录号WOS:000300184800057
项目编号30972993 ; Z080507030808011
资助机构National Natural Science Foundation of China ; Peking National Natural Science Foundation
引用统计
被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64393
专题北京大学第一临床医学院_男科中心
作者单位1.Capital Med Univ, Beijing ChaoYang Hosp, Dept Ophthalmol, Beijing 100043, Peoples R China
2.Peking Univ, Peking Univ Hosp 1, Androl Ctr, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Xin, Hua,Zhou, Feng,Liu, Tao,et al. Icariin Ameliorates Streptozotocin-Induced Diabetic Retinopathy in Vitro and in Vivo[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2012,13(1):866-878.
APA Xin, Hua.,Zhou, Feng.,Liu, Tao.,Li, Guang-Yong.,Liu, Jing.,...&Xin, Zhong-Cheng.(2012).Icariin Ameliorates Streptozotocin-Induced Diabetic Retinopathy in Vitro and in Vivo.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,13(1),866-878.
MLA Xin, Hua,et al."Icariin Ameliorates Streptozotocin-Induced Diabetic Retinopathy in Vitro and in Vivo".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 13.1(2012):866-878.
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