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学科主题: 临床医学
题名:
Icariin Ameliorates Streptozotocin-Induced Diabetic Retinopathy in Vitro and in Vivo
作者: Xin, Hua1; Zhou, Feng2; Liu, Tao2; Li, Guang-Yong2; Liu, Jing2; Gao, Zhe-Zhu2; Bai, Guang-Yi2; Lu, Hong1; Xin, Zhong-Cheng2
关键词: icariin ; streptozotocin ; diabetes ; retina ; diabetic retinopathy
刊名: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
发表日期: 2012
DOI: 10.3390/ijms13010866
卷: 13, 期:1, 页:866-878
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
关键词[WOS]: ERECTILE FUNCTION ; GROWTH-FACTOR ; RATS ; EXPRESSION ; CELLS ; COMPLICATIONS ; EPIDEMIOLOGY ; DYSFUNCTION ; BREAKDOWN ; DISEASE
英文摘要:

This study investigated the effect of Icariin (ICA) supplementation on diabetic retinopathy (DR) in a streptozotocin-induced diabetic rat model system. Fifty Sprague Dawley rats were randomly distributed into a control group and a streptozotocin-induced diabetes group. Diabetic rats were randomly divided into two groups; one group received ICA 5 mg/kg/day for 12 weeks by oral gavage; the other group received saline gavage as a placebo. Retinal morphological changes, endothelial markers (RECA), collagen IV (Col-IV), vascular endothelial growth factor (VEGF), and neuropathic changes (Thy-1 and Brn3a expression) of the retinal ganglion cells (RGCs) were investigated. The effects of ICA at various concentrations (0, 10(1), 10(2), 10(3) nmol/mL) on neurite growth were investigated also in retinal ganglion cells (RGC) cultured from both diabetic and normal animals. Numerous pathological changes (deceased expression of RECA, VEGF, Thy-1, and Brn3a as well as decreased Collagen IV and Muller cell content) were noted in the retinal vessels of diabetic rats; these changes were attenuated in diabetic animals that received ICA. ICA enhanced neurite growth in RGC from both normal rats and diabetic rats in a dose dependent fashion. ICA may be useful in the treatment of diabetic retinopathy. Further investigations are indicated.

语种: 英语
所属项目编号: 30972993 ; Z080507030808011
项目资助者: National Natural Science Foundation of China ; Peking National Natural Science Foundation
WOS记录号: WOS:000300184800057
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64393
Appears in Collections:北京大学第一临床医学院_男科中心_期刊论文

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作者单位: 1.Capital Med Univ, Beijing ChaoYang Hosp, Dept Ophthalmol, Beijing 100043, Peoples R China
2.Peking Univ, Peking Univ Hosp 1, Androl Ctr, Beijing 100034, Peoples R China

Recommended Citation:
Xin, Hua,Zhou, Feng,Liu, Tao,et al. Icariin Ameliorates Streptozotocin-Induced Diabetic Retinopathy in Vitro and in Vivo[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2012,13(1):866-878.
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