学科主题临床医学
Hepatitis C virus nonstructural protein specific T cells are associated with virological responses to combination therapy in chronic HCV patients
Zhang, Yonghong1; Liu, Yali1; Zhao, Yan1; Shi, Lingxian1; Ma, Lina1; Yan, Huiping1; Wu, Hao1; Wei, Lai2; Dong, Tao3; Chen, Xinyue1
关键词combination therapy hepatitis C virus (HCV) nonstructural protein (NS) sustained virological response T cell
刊名LIVER INTERNATIONAL
2012
DOI10.1111/j.1478-3231.2011.02652.x
32期:1页:102-109
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]VIRAL CLEARANCE ; INTERFERON-ALPHA ; PLUS RIBAVIRIN ; GENETIC-VARIATION ; IMMUNE-RESPONSES ; I INTERFERON ; INFECTION ; CD4(+) ; PEGINTERFERON ; PERSISTENCE
英文摘要

Background: Virus-specific T-cell responses play a major role in antiviral immune response. However, the effect of hepatitis C virus (HCV)-specific T-cell responses on combination therapy still remains controversial. Aims: To identify the association between HCV-specific T cell responses and efficiency of combination therapy. Methods: To address this issue, a longitudinal analysis of HCV-specific T-cell responses to overlapping peptides covering HCV-nonstructural protein (NS) was performed using ELISpot assay in 48 chronically infected HCV-1b patients during combination treatment with peginterferon-alfa and ribavirin. Results: Fifty-two percent of chronic HCV patients showed detectable HCV-NS3, NS4 or NS5A specific T-cell responses before therapy, with NS3 appearing to be the most immunodominant protein followed by NS5A and NS4. In addition, the percentage of patients responding to peptide stimulation was higher in patients with sustained virological response (SVR) when compared with those without SVR. Dynamics of HCV-NS-specific T-cell responses were further analysed; we found that HCV-specific T-cell responses maintained higher levels at 12 weeks into treatment in patients with SVR. In contrast, HCV-specific Tcell responses in patients without SVR declined significantly at 4 weeks into treatment and maintained low levels at 12 weeks. Conclusion: We found that the HCV-specific T-cell responses were associated with good viral control in patients with combination therapy.

语种英语
WOS记录号WOS:000298302700015
项目编号QN2009-29 ; D09050703560902 ; 2008ZX10002-013
资助机构Beijing Municipal Health Bureau ; Beijing Municipal Science &amp ; Technology Commission ; National S&amp ; T Major Project for Infectious Diseases Control
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64394
专题北京大学第二临床医学院_北京大学肝病研究所
作者单位1.Univ Oxford, MRC Human Immunolgy Unit, WIMM, Oxford, England
2.Capital Med Univ, Beijing Youan Hosp, Beijing 100069, Peoples R China
3.Peking Univ, Inst Hepatol, Peoples Hosp, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Yonghong,Liu, Yali,Zhao, Yan,et al. Hepatitis C virus nonstructural protein specific T cells are associated with virological responses to combination therapy in chronic HCV patients[J]. LIVER INTERNATIONAL,2012,32(1):102-109.
APA Zhang, Yonghong.,Liu, Yali.,Zhao, Yan.,Shi, Lingxian.,Ma, Lina.,...&Chen, Xinyue.(2012).Hepatitis C virus nonstructural protein specific T cells are associated with virological responses to combination therapy in chronic HCV patients.LIVER INTERNATIONAL,32(1),102-109.
MLA Zhang, Yonghong,et al."Hepatitis C virus nonstructural protein specific T cells are associated with virological responses to combination therapy in chronic HCV patients".LIVER INTERNATIONAL 32.1(2012):102-109.
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