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学科主题: 基础医学
题名:
CMTM8 induces caspase-dependent and -independent apoptosis through a mitochondria-mediated pathway
作者: Jin, Caining; Wang, Ying; Han, Wenling; Zhang, Yingmei; He, Qihua; Li, Dan; Yin, Caihua; Tian, Linjie; Liu, Dazhen; Song, Quanshen; Ma, Dalong
刊名: JOURNAL OF CELLULAR PHYSIOLOGY
发表日期: 2007-04-01
DOI: 10.1002/jcp.20914
卷: 211, 期:1, 页:112-120
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology ; Physiology
研究领域[WOS]: Cell Biology ; Physiology
关键词[WOS]: GROWTH-FACTOR RECEPTOR ; MONOCLONAL-ANTIBODY ; TYROSINE KINASE ; PANCREATIC-CANCER ; CYTOCHROME-C ; INDUCTION ; INHIBITION ; PROTEIN ; CELLS ; DEATH
英文摘要:

The mitochondria-mediated apoptotic pathway is regulated by members of the Bcl-2 family. Epidermal growth factor (EGF) induces Bad phosphorylation at Ser(112) via mitogen-activated protein kinase (MAPK), impairing its binding to Bcl-2 and Bcl-xL and interfering with their anti-apoptotic functions. In the current study, we utilized Western blot, immunofluorescence, flow cytometry, and confocal microscopy to examine the effects of CMTM8 overexpression on apoptosis. Our data indicated levels of Bad-S-112 phosphorylation were lower in CMTM8-transfected cells compared to pCDB-transfected cells. Caspase-dependent and independent mediated apoptosis, induced by CMTM8 overexpression, was facilitated by the mitochondria and inhibited by knockdown of Bad or overexpression of Bcl-xL. Previous research in our laboratory also demonstrated CMTM8 attenuated EGFR-mediated signaling pathways by decreasing ERK1/2phosphorylation levels. These data implicate CMTM8 as a negative regulator of EGF-induced signaling, with potential use as a novel therapeutic gene for EGFR-targeted anticancer gene therapy.

语种: 英语
WOS记录号: WOS:000244672700011
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64396
Appears in Collections:基础医学院_免疫学系_期刊论文

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作者单位: 1.Peking Univ, Sch Basic Med Sci, Lab Med Immunol, Beijing 100083, Peoples R China
2.Peking Univ, Ctr Human Dis Genom, Beijing 100083, Peoples R China
3.Peking Univ, Hlth & Med Anal Ctr, Beijing 100083, Peoples R China

Recommended Citation:
Jin, Caining,Wang, Ying,Han, Wenling,et al. CMTM8 induces caspase-dependent and -independent apoptosis through a mitochondria-mediated pathway[J]. JOURNAL OF CELLULAR PHYSIOLOGY,2007,211(1):112-120.
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