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学科主题基础医学
CMTM8 induces caspase-dependent and -independent apoptosis through a mitochondria-mediated pathway
Jin, Caining; Wang, Ying; Han, Wenling; Zhang, Yingmei; He, Qihua; Li, Dan; Yin, Caihua; Tian, Linjie; Liu, Dazhen; Song, Quanshen; Ma, Dalong
刊名JOURNAL OF CELLULAR PHYSIOLOGY
2007-04-01
DOI10.1002/jcp.20914
211期:1页:112-120
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology ; Physiology
研究领域[WOS]Cell Biology ; Physiology
关键词[WOS]GROWTH-FACTOR RECEPTOR ; MONOCLONAL-ANTIBODY ; TYROSINE KINASE ; PANCREATIC-CANCER ; CYTOCHROME-C ; INDUCTION ; INHIBITION ; PROTEIN ; CELLS ; DEATH
英文摘要

The mitochondria-mediated apoptotic pathway is regulated by members of the Bcl-2 family. Epidermal growth factor (EGF) induces Bad phosphorylation at Ser(112) via mitogen-activated protein kinase (MAPK), impairing its binding to Bcl-2 and Bcl-xL and interfering with their anti-apoptotic functions. In the current study, we utilized Western blot, immunofluorescence, flow cytometry, and confocal microscopy to examine the effects of CMTM8 overexpression on apoptosis. Our data indicated levels of Bad-S-112 phosphorylation were lower in CMTM8-transfected cells compared to pCDB-transfected cells. Caspase-dependent and independent mediated apoptosis, induced by CMTM8 overexpression, was facilitated by the mitochondria and inhibited by knockdown of Bad or overexpression of Bcl-xL. Previous research in our laboratory also demonstrated CMTM8 attenuated EGFR-mediated signaling pathways by decreasing ERK1/2phosphorylation levels. These data implicate CMTM8 as a negative regulator of EGF-induced signaling, with potential use as a novel therapeutic gene for EGFR-targeted anticancer gene therapy.

语种英语
WOS记录号WOS:000244672700011
引用统计
被引频次:19[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64396
专题北京大学基础医学院_免疫学系
作者单位1.Peking Univ, Sch Basic Med Sci, Lab Med Immunol, Beijing 100083, Peoples R China
2.Peking Univ, Ctr Human Dis Genom, Beijing 100083, Peoples R China
3.Peking Univ, Hlth & Med Anal Ctr, Beijing 100083, Peoples R China
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GB/T 7714
Jin, Caining,Wang, Ying,Han, Wenling,et al. CMTM8 induces caspase-dependent and -independent apoptosis through a mitochondria-mediated pathway[J]. JOURNAL OF CELLULAR PHYSIOLOGY,2007,211(1):112-120.
APA Jin, Caining.,Wang, Ying.,Han, Wenling.,Zhang, Yingmei.,He, Qihua.,...&Ma, Dalong.(2007).CMTM8 induces caspase-dependent and -independent apoptosis through a mitochondria-mediated pathway.JOURNAL OF CELLULAR PHYSIOLOGY,211(1),112-120.
MLA Jin, Caining,et al."CMTM8 induces caspase-dependent and -independent apoptosis through a mitochondria-mediated pathway".JOURNAL OF CELLULAR PHYSIOLOGY 211.1(2007):112-120.
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