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学科主题: 临床医学
题名:
Persistence of newly detected human papillomavirus type 31 infection, stratified by variant lineage
作者: Xi, Long Fu1,2; Schiffman, Mark3; Koutsky, Laura A.2; He, Zhonghu4; Winer, Rachel L.2; Hulbert, Ayaka; Lee, Shu-Kuang2; Ke, Yang4; Kiviat, Nancy B.
关键词: human papillomavirus ; variants ; persistence
刊名: INTERNATIONAL JOURNAL OF CANCER
发表日期: 2013-02-01
DOI: 10.1002/ijc.27689
卷: 132, 期:3, 页:549-555
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: CERVICAL INTRAEPITHELIAL NEOPLASIA ; NATURAL-HISTORY ; RISK ; WOMEN ; HPV ; LESIONS ; POLYMORPHISM ; HUMAN-PAPILLOMAVIRUS-16 ; PREDICTOR ; SEQUENCE
英文摘要:

Variants of human papillomavirus (HPV) type 31 have been shown to be related both to risk of cervical lesions and racial composition of a population. It is largely undetermined whether variants differ in their likelihood of persistence. Study subjects were women who participated in the ASCUS-LSIL Triage Study and who had a newly detected HPV31 infection during a two-year follow-up with six-month intervals. HPV31 isolates were characterized by sequencing and assigned to one of three variant lineages. Loss of the newly detected HPV31 infection was detected in 76 (47.5%) of the 160 women (32/67 with A variants, 16/27 with B variants and 28/66 with C variants). The adjusted hazard ratio associating loss of the infection was 1.2 (95% CI, 0.72.1) for women with A variants and 2.1 (95% CI, 1.23.5) for women with B variants when compared with those with C variants. Infections with A and C variants were detected in 50 and 41 Caucasian women and in 15 and 23 African-American women, respectively. The likelihood of clearance of the infection was significantly lower in African-American women with C variants than in African-American women with A variants (p = 0.05). There was no difference in the likelihood of clearance between A and C variants among Caucasian women. Our data indicated that infections with B variants were more likely to resolve than those with C variants. The difference in clearance of A vs. C variants in African-Americans, but not in Caucasians, suggests a possibility of the race-related influence in retaining the variant-specific infection.

语种: 英语
所属项目编号: CA133569
项目资助者: Public Health Service
WOS记录号: WOS:000311620100013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64397
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: 1.Univ Washington, Harborview Med Ctr, Dept Pathol, NJB,Sch Publ Hlth,Sch Med, Seattle, WA 98104 USA
2.Univ Washington, Sch Publ Hlth, Dept Epidemiol, Seattle, WA 98104 USA
3.NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA
4.Peking Univ, Sch Oncol, Key Lab Carcinogenesis & Translat Res, Beijing 100871, Peoples R China

Recommended Citation:
Xi, Long Fu,Schiffman, Mark,Koutsky, Laura A.,et al. Persistence of newly detected human papillomavirus type 31 infection, stratified by variant lineage[J]. INTERNATIONAL JOURNAL OF CANCER,2013,132(3):549-555.
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