IR@PKUHSC  > 北京大学临床肿瘤学院
学科主题临床医学
Persistence of newly detected human papillomavirus type 31 infection, stratified by variant lineage
Xi, Long Fu1,2; Schiffman, Mark3; Koutsky, Laura A.2; He, Zhonghu4; Winer, Rachel L.2; Hulbert, Ayaka; Lee, Shu-Kuang2; Ke, Yang4; Kiviat, Nancy B.
关键词human papillomavirus variants persistence
刊名INTERNATIONAL JOURNAL OF CANCER
2013-02-01
DOI10.1002/ijc.27689
132期:3页:549-555
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]CERVICAL INTRAEPITHELIAL NEOPLASIA ; NATURAL-HISTORY ; RISK ; WOMEN ; HPV ; LESIONS ; POLYMORPHISM ; HUMAN-PAPILLOMAVIRUS-16 ; PREDICTOR ; SEQUENCE
英文摘要

Variants of human papillomavirus (HPV) type 31 have been shown to be related both to risk of cervical lesions and racial composition of a population. It is largely undetermined whether variants differ in their likelihood of persistence. Study subjects were women who participated in the ASCUS-LSIL Triage Study and who had a newly detected HPV31 infection during a two-year follow-up with six-month intervals. HPV31 isolates were characterized by sequencing and assigned to one of three variant lineages. Loss of the newly detected HPV31 infection was detected in 76 (47.5%) of the 160 women (32/67 with A variants, 16/27 with B variants and 28/66 with C variants). The adjusted hazard ratio associating loss of the infection was 1.2 (95% CI, 0.72.1) for women with A variants and 2.1 (95% CI, 1.23.5) for women with B variants when compared with those with C variants. Infections with A and C variants were detected in 50 and 41 Caucasian women and in 15 and 23 African-American women, respectively. The likelihood of clearance of the infection was significantly lower in African-American women with C variants than in African-American women with A variants (p = 0.05). There was no difference in the likelihood of clearance between A and C variants among Caucasian women. Our data indicated that infections with B variants were more likely to resolve than those with C variants. The difference in clearance of A vs. C variants in African-Americans, but not in Caucasians, suggests a possibility of the race-related influence in retaining the variant-specific infection.

语种英语
WOS记录号WOS:000311620100013
项目编号CA133569
资助机构Public Health Service
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64397
专题北京大学临床肿瘤学院
北京大学临床肿瘤学院_遗传学研究室
作者单位1.Univ Washington, Harborview Med Ctr, Dept Pathol, NJB,Sch Publ Hlth,Sch Med, Seattle, WA 98104 USA
2.Univ Washington, Sch Publ Hlth, Dept Epidemiol, Seattle, WA 98104 USA
3.NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA
4.Peking Univ, Sch Oncol, Key Lab Carcinogenesis & Translat Res, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Xi, Long Fu,Schiffman, Mark,Koutsky, Laura A.,et al. Persistence of newly detected human papillomavirus type 31 infection, stratified by variant lineage[J]. INTERNATIONAL JOURNAL OF CANCER,2013,132(3):549-555.
APA Xi, Long Fu.,Schiffman, Mark.,Koutsky, Laura A..,He, Zhonghu.,Winer, Rachel L..,...&Kiviat, Nancy B..(2013).Persistence of newly detected human papillomavirus type 31 infection, stratified by variant lineage.INTERNATIONAL JOURNAL OF CANCER,132(3),549-555.
MLA Xi, Long Fu,et al."Persistence of newly detected human papillomavirus type 31 infection, stratified by variant lineage".INTERNATIONAL JOURNAL OF CANCER 132.3(2013):549-555.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Xi, Long Fu]的文章
[Schiffman, Mark]的文章
[Koutsky, Laura A.]的文章
百度学术
百度学术中相似的文章
[Xi, Long Fu]的文章
[Schiffman, Mark]的文章
[Koutsky, Laura A.]的文章
必应学术
必应学术中相似的文章
[Xi, Long Fu]的文章
[Schiffman, Mark]的文章
[Koutsky, Laura A.]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。