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Prognostic value of metastatic lymph node ratio as an additional tool to the TNM stage system in gastric cancer
Wu, X. -J.; Miao, R. -L.; Li, Z. -Y.; Bu, Z. -D.; Zhang, L. -H.; Wu, A. -W.; Zong, X. -L.; Li, S. -X.; Shan, F.; Ji, X.; Ren, H.; Ji, J. -F.
关键词Gastric cancer Lymph node ratio Prognosis TNM stage
刊名EJSO
2015-07-01
DOI10.1016/j.ejso.2015.03.225
41期:7页:927-933
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Surgery
研究领域[WOS]Oncology ; Surgery
关键词[WOS]CARCINOMA ; NUMBER ; ADENOCARCINOMA ; EXPERIENCE ; RESECTION ; SURVIVAL ; SCHEMES ; UNION
英文摘要

Background: Gastric cancer is one of most common malignancies in the world. Currently the prognostic prediction is entirely based on the TNM staging system. In this study, we evaluated whether metastatic lymph node ratio (rN) at the time of surgery would improve the prognostic prediction in conjunction with the TNM staging system.

Methods: This retrospective study includes 745 patients, who had been referred for surgery due to gastric cancer between 1995 and 2007 and had at least 15 lymph nodes examined at the time of surgery without preoperative treatment. Clinicopathologic features and overall survival were analyzed using univariate and multivariate modes to identify the risk factors for overall survival.

Results: Median overall survival of all patients analyzed is 57.8 months and 5-year overall survival is 49.5%. Tumor site, macroscopic type, pTNM stage, and rN stage are identified as independent prognostic factors. Increased positive lymph node ratio correlates with shorter survival in all patients and in each T and N stage. In stage III gastric cancer patients, rN stage shows additional prognostic value on overall survival (p<0.001).

Conclusions: rN stage is a simple and promising prognostic factor of gastric cancer after surgery in addition to the TNM stage system especially in stage III patients. But the independent prognostic value of rN stage in stage I, 11 and IV gastric cancer is yet to be determined. (C) 2015 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000357228000018
项目编号1122-02-1402
资助机构Open Fund of Key Laboratory of Carcinogenesis, Ministry of Education
引用统计
被引频次:21[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64401
专题北京大学临床肿瘤学院_胃肠肿瘤中心
北京大学临床肿瘤学院_胃肠肿瘤中心一病区
作者单位Peking Univ, Key Lab Carcinogenesis & Translat Res, Dept Gastrointestinal Surg, Minist Educ,Canc Hosp & Inst, Beijing 100142, Peoples R China
推荐引用方式
GB/T 7714
Wu, X. -J.,Miao, R. -L.,Li, Z. -Y.,et al. Prognostic value of metastatic lymph node ratio as an additional tool to the TNM stage system in gastric cancer[J]. EJSO,2015,41(7):927-933.
APA Wu, X. -J..,Miao, R. -L..,Li, Z. -Y..,Bu, Z. -D..,Zhang, L. -H..,...&Ji, J. -F..(2015).Prognostic value of metastatic lymph node ratio as an additional tool to the TNM stage system in gastric cancer.EJSO,41(7),927-933.
MLA Wu, X. -J.,et al."Prognostic value of metastatic lymph node ratio as an additional tool to the TNM stage system in gastric cancer".EJSO 41.7(2015):927-933.
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