北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学临床肿瘤学院  > 胃肠肿瘤中心  > 期刊论文
学科主题: 临床医学
题名:
Prognostic value of metastatic lymph node ratio as an additional tool to the TNM stage system in gastric cancer
作者: Wu, X. -J.; Miao, R. -L.; Li, Z. -Y.; Bu, Z. -D.; Zhang, L. -H.; Wu, A. -W.; Zong, X. -L.; Li, S. -X.; Shan, F.; Ji, X.; Ren, H.; Ji, J. -F.
关键词: Gastric cancer ; Lymph node ratio ; Prognosis ; TNM stage
刊名: EJSO
发表日期: 2015-07-01
DOI: 10.1016/j.ejso.2015.03.225
卷: 41, 期:7, 页:927-933
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Surgery
研究领域[WOS]: Oncology ; Surgery
关键词[WOS]: CARCINOMA ; NUMBER ; ADENOCARCINOMA ; EXPERIENCE ; RESECTION ; SURVIVAL ; SCHEMES ; UNION
英文摘要:

Background: Gastric cancer is one of most common malignancies in the world. Currently the prognostic prediction is entirely based on the TNM staging system. In this study, we evaluated whether metastatic lymph node ratio (rN) at the time of surgery would improve the prognostic prediction in conjunction with the TNM staging system.

Methods: This retrospective study includes 745 patients, who had been referred for surgery due to gastric cancer between 1995 and 2007 and had at least 15 lymph nodes examined at the time of surgery without preoperative treatment. Clinicopathologic features and overall survival were analyzed using univariate and multivariate modes to identify the risk factors for overall survival.

Results: Median overall survival of all patients analyzed is 57.8 months and 5-year overall survival is 49.5%. Tumor site, macroscopic type, pTNM stage, and rN stage are identified as independent prognostic factors. Increased positive lymph node ratio correlates with shorter survival in all patients and in each T and N stage. In stage III gastric cancer patients, rN stage shows additional prognostic value on overall survival (p<0.001).

Conclusions: rN stage is a simple and promising prognostic factor of gastric cancer after surgery in addition to the TNM stage system especially in stage III patients. But the independent prognostic value of rN stage in stage I, 11 and IV gastric cancer is yet to be determined. (C) 2015 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 1122-02-1402
项目资助者: Open Fund of Key Laboratory of Carcinogenesis, Ministry of Education
WOS记录号: WOS:000357228000018
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64401
Appears in Collections:北京大学临床肿瘤学院_胃肠肿瘤中心_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: Peking Univ, Key Lab Carcinogenesis & Translat Res, Dept Gastrointestinal Surg, Minist Educ,Canc Hosp & Inst, Beijing 100142, Peoples R China

Recommended Citation:
Wu, X. -J.,Miao, R. -L.,Li, Z. -Y.,et al. Prognostic value of metastatic lymph node ratio as an additional tool to the TNM stage system in gastric cancer[J]. EJSO,2015,41(7):927-933.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Wu, X. -J.]'s Articles
[Miao, R. -L.]'s Articles
[Li, Z. -Y.]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Wu, X. -J.]‘s Articles
[Miao, R. -L.]‘s Articles
[Li, Z. -Y.]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace