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Investigations on gastric and colorectum cancer by FTIR spectroscopy
Ling Xiao-Feng; Xu Yi-Zhuang; Wang Li-Xin; Li Wei-Hong; Zhang Yuan-Fu; Yang Zhan-Lan; Hou Chun-Sheng; Zhou Xiao-Si; Wu Jin-Guang; Xu Zhi
关键词gastric cancer colorectal cancer FTIR
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary

Thirty-one pairs of FFIR spectra of samples, including gastric and colorectal cancer and the corresponding normal tissues, were collected after surgery. FTIR spectra of cancerous tissue were significantly different from those of normal tissues. ( I) Alterations of bands related to lipid: 2955, 2920, 2870, 2850 and 1740 cm(-1) appeared less frequently in malignant tissue(P < 0.001). The ratio of I-1460/I-1400 in malignant tissue decreased significantly(P < 0.001), indicating that the relative quantity of lipid in malignant tissue decreased significantly. (2) Alterations of bands related to protein: in malignant tissue, the band of N-H and O-H shifted to a lower wave number(P = 0.025), suggesting that the degree of hydrogen-bonding of N-H and O-H increased. In malignant tissue, the ratios of I-3375/I-1460, I-1640/I-1460, I-1550/I-1460 raised(P < 0.01), respectively. These changes Illustrate that the relative quantity of protein to lipid in malignant tissue increased significantly. The ratio of HW1550/I-1550 increased obviously(P = 0.036), while HW1550 decreased significantly P = 0. 05 compared with those of normal tissue. We can conclude that the secondary structure of protein in malignant tissue changed. (3) Alterations of bands related to carbohydrate: in malignant tissue, the ratio of I-1160/I-1460, reduced (P = 0.002). It might be due to the lessen of glycoprotein on the. surface of malignant tissue, reversely, the ratio of I-1120/I-1460 raised(P = 0.019). The possible reason was that the glucogen grains on the surface of the malignant tissue increased. (4) Alterations of band related to nucleic acid: in normal tissue, the peak of P = 0 antisymmetric vibration was at (1241.61 +/- 6.15) cm(-1). In malignant tissue, the band shifted toward a higher wave number(P = 0.033) due to the decreased hydrogen-bonding of P = 0. FTIR spectroscopy could be a powerful tool for cancer diagnosis.

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作者单位1.Peking Univ, Hosp 3, Dept Gen Surg, Beijing 100083, Peoples R China
2.Peking Univ, Coll Chem Mol Engn, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Ling Xiao-Feng,Xu Yi-Zhuang,Wang Li-Xin,et al. Investigations on gastric and colorectum cancer by FTIR spectroscopy[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2007,28(3):445-449.
APA Ling Xiao-Feng.,Xu Yi-Zhuang.,Wang Li-Xin.,Li Wei-Hong.,Zhang Yuan-Fu.,...&Xu Zhi.(2007).Investigations on gastric and colorectum cancer by FTIR spectroscopy.CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,28(3),445-449.
MLA Ling Xiao-Feng,et al."Investigations on gastric and colorectum cancer by FTIR spectroscopy".CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 28.3(2007):445-449.
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