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学科主题: 临床医学
题名:
Investigations on gastric and colorectum cancer by FTIR spectroscopy
作者: Ling Xiao-Feng; Xu Yi-Zhuang; Wang Li-Xin; Li Wei-Hong; Zhang Yuan-Fu; Yang Zhan-Lan; Hou Chun-Sheng; Zhou Xiao-Si; Wu Jin-Guang; Xu Zhi
关键词: gastric cancer ; colorectal cancer ; FTIR
刊名: CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
发表日期: 2007-03-01
卷: 28, 期:3, 页:445-449
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
关键词[WOS]: CELLS
英文摘要:

Thirty-one pairs of FFIR spectra of samples, including gastric and colorectal cancer and the corresponding normal tissues, were collected after surgery. FTIR spectra of cancerous tissue were significantly different from those of normal tissues. ( I) Alterations of bands related to lipid: 2955, 2920, 2870, 2850 and 1740 cm(-1) appeared less frequently in malignant tissue(P < 0.001). The ratio of I-1460/I-1400 in malignant tissue decreased significantly(P < 0.001), indicating that the relative quantity of lipid in malignant tissue decreased significantly. (2) Alterations of bands related to protein: in malignant tissue, the band of N-H and O-H shifted to a lower wave number(P = 0.025), suggesting that the degree of hydrogen-bonding of N-H and O-H increased. In malignant tissue, the ratios of I-3375/I-1460, I-1640/I-1460, I-1550/I-1460 raised(P < 0.01), respectively. These changes Illustrate that the relative quantity of protein to lipid in malignant tissue increased significantly. The ratio of HW1550/I-1550 increased obviously(P = 0.036), while HW1550 decreased significantly P = 0. 05 compared with those of normal tissue. We can conclude that the secondary structure of protein in malignant tissue changed. (3) Alterations of bands related to carbohydrate: in malignant tissue, the ratio of I-1160/I-1460, reduced (P = 0.002). It might be due to the lessen of glycoprotein on the. surface of malignant tissue, reversely, the ratio of I-1120/I-1460 raised(P = 0.019). The possible reason was that the glucogen grains on the surface of the malignant tissue increased. (4) Alterations of band related to nucleic acid: in normal tissue, the peak of P = 0 antisymmetric vibration was at (1241.61 +/- 6.15) cm(-1). In malignant tissue, the band shifted toward a higher wave number(P = 0.033) due to the decreased hydrogen-bonding of P = 0. FTIR spectroscopy could be a powerful tool for cancer diagnosis.

语种: 中文
WOS记录号: WOS:000245094400012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64402
Appears in Collections:北京大学第三临床医学院_普通外科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Dept Gen Surg, Beijing 100083, Peoples R China
2.Peking Univ, Coll Chem Mol Engn, Beijing 100871, Peoples R China

Recommended Citation:
Ling Xiao-Feng,Xu Yi-Zhuang,Wang Li-Xin,et al. Investigations on gastric and colorectum cancer by FTIR spectroscopy[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2007,28(3):445-449.
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