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学科主题: 基础医学
题名:
Element distribution in the brain sections of rats measured by synchrotron radiation X-ray fluorescence
作者: Liu, NQ; Zhang, E; Wang, XE; Zhang, ZY; Chai, ZF; Huang, YY; He, W; Zhao, XQ; Zuo, AJ; Yang, R
关键词: trace element ; cerebral cortex ; hippocampus ; thalamus ; hippocampal fissure ; perfusion ; synchrotron radiation X-ray fluorescence
刊名: SPECTROCHIMICA ACTA PART B-ATOMIC SPECTROSCOPY
发表日期: 2004-02-27
DOI: 10.1016/j.sab.2003.12.006
卷: 59, 期:2, 页:255-260
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Spectroscopy
研究领域[WOS]: Spectroscopy
关键词[WOS]: II IODOTHYRONINE DEIODINASE ; CLONING ; IODINE ; ERYTHROCYTES ; DEFICIENCY ; BROMINE ; CDNA
英文摘要:

The concentration of trace elements in brain sections was measured by synchrotron radiation X-ray fluorescence. The relative concentration was calculated by means of the normalization of Compton scattering intensity approximately 22 keV, after the normalization for collecting time of X-ray spectrum and the counting of the ion chamber, and subtracting the contribution of the polycarbonate film for supporting sample. Furthermore, the statistical evaluation of the element distribution in various regions of the brain sections of the 20-day-old rats was tested. For investigating the distribution of elements in the brain of iodine deficient rats, Wistar rats were fed with iodine deficient diet and deionized water (ID group). The rats were fed the same iodine deficient diet, but drank KIO3 solution as control (CT group). The results showed that the contents of calcium (Ca) in thalamus (TH) and copper (Cu) and iron (Fe) in cerebral cortex (CX) of ID rats were significantly lower than that of control rats, while the contents of phosphor (P), sulfur (S), potassium (K), rubidium (Rb), bromine (Br), chlorine (CI), zinc (Zn), Ca and Cu of ID in hippocampus (H) and the contents of Br, Cl, Zn and Ca in cerebral cortex of ID rats were significantly higher. Especially, the difference of Br, Cl, Zn and Ca in H between ID and CT was more significant. The contents of all elements measured in H were higher than (or equal to) CX and/or TH for both groups, except low Cl of the control rats. Furthermore Zn and Cu contents along the hippocampal fissure in both groups were 1.5 (P<0.001) and 0.87(P<0.03) times higher than in hippocampus, respectively. Considering the results of cluster analysis our study shows that the marked alterations in the spatial distribution of Zn and Ca of ID rats brain during brain development stages. In addition, the effect of the perfusion with 0.9% NaCl solution before taking brain on the distribution of elements in the brain sections was observed and discussed. (C) 2003 Elsevier B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000220132300011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64403
Appears in Collections:基础医学院_解剖学与组织胚胎学系_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst High Energy Phys, Lab Nucl Analyt Tech, Beijing 100039, Peoples R China
2.Tianjin Med Coll, Inst Endocrinol, Tianjin 300070, Peoples R China
3.Peking Univ, Dept Anat, Hlth Sci Ctr, Beijing 100083, Peoples R China

Recommended Citation:
Liu, NQ,Zhang, E,Wang, XE,et al. Element distribution in the brain sections of rats measured by synchrotron radiation X-ray fluorescence[J]. SPECTROCHIMICA ACTA PART B-ATOMIC SPECTROSCOPY,2004,59(2):255-260.
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