IR@PKUHSC  > 北京大学基础医学院  > 病原生物学系
学科主题基础医学
Helicobacter pylori in the oral cavity and gastric mucosa: a meta-analysis
Zou, Qing-Hua1; Li, Ren-Qing2
关键词gastric mucosa Helicobacter pylori meta-analysis oral cavity oral mucosa saliva
刊名JOURNAL OF ORAL PATHOLOGY & MEDICINE
2011-04-01
DOI10.1111/j.1600-0714.2011.01006.x
40期:4页:317-324
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dentistry, Oral Surgery & Medicine ; Pathology
研究领域[WOS]Dentistry, Oral Surgery & Medicine ; Pathology
关键词[WOS]POLYMERASE-CHAIN-REACTION ; DENTAL PLAQUE ; HIGH PREVALENCE ; PERIODONTITIS PATIENTS ; ERADICATION THERAPY ; PCR ASSAY ; INFECTION ; DNA ; COLONIZATION ; SALIVA
英文摘要

Background:

Helicobacter pylori have been found in the oral cavity and stomach. This study is to establish whether there might be any associations between isolates of H. pylori in the oral cavity and those in the stomach by meta-analysis.

Methods:

Studies reporting raw data on the prevalence of H. pylori infection in the oral cavity in gastric H. pylori-positive and H. pylori-negative patients, in patients with gastroesophageal diseases, and in healthy individuals and studies reporting data on the eradication rate in the oral cavity or stomach, published in the English language, were identified through MEDLINE and EMBASE up to May 2010.

Results:

The prevalence of H. pylori infection in the oral cavity in gastric H. pylori-positive patients was significantly higher (45.0%) than that in gastric H. pylori-negative patients (23.9%). The pooled odds ration (OR) was 3.61 and the 95% CI was 1.91-6.82 (P < 0.0001). Different diagnostic methods produced different pooled ORs with PCR the highest (OR = 5.11, 95% CI: 2.08-12.54, P = 0.0004) and rapid urease test (RUT) the lowest (OR = 2.00, 95% CI: 0.80-5.00, P = 0.14). The 44.8% (91/203) prevalence of H. pylori infection in the oral cavity in patients with clinical and/or histological gastroesophageal diseases was significantly higher than the 13.2% (21/159) in patients with non-ulcerous dyspepsia or healthy controls (OR = 5.15, 95% CI: 2.97-8.92, P < 0.00001). The eradication efficiency in stomach is 85.8% (187/218), while in oral cavity it is only 5.7% (9/158). The OR is 55.59, P < 0.00001.

Conclusions:

There is a close relation between the infection of H. pylori in the oral cavity and stomach. H. pylori in the oral cavity are more difficult to be eradicated than in the stomach. It may be a source of reinfection.

语种英语
WOS记录号WOS:000288702800007
项目编号891ja-213-741-132
资助机构Peking University
引用统计
被引频次:38[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64408
专题北京大学基础医学院_病原生物学系
北京大学基础医学院
作者单位1.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Beijing 100191, Peoples R China
2.Beijing Ctr Dis Control & Prevent, Beijing, Peoples R China
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Zou, Qing-Hua,Li, Ren-Qing. Helicobacter pylori in the oral cavity and gastric mucosa: a meta-analysis[J]. JOURNAL OF ORAL PATHOLOGY & MEDICINE,2011,40(4):317-324.
APA Zou, Qing-Hua,&Li, Ren-Qing.(2011).Helicobacter pylori in the oral cavity and gastric mucosa: a meta-analysis.JOURNAL OF ORAL PATHOLOGY & MEDICINE,40(4),317-324.
MLA Zou, Qing-Hua,et al."Helicobacter pylori in the oral cavity and gastric mucosa: a meta-analysis".JOURNAL OF ORAL PATHOLOGY & MEDICINE 40.4(2011):317-324.
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