IR@PKUHSC  > 北京大学公共卫生学院
学科主题公共卫生
Size-fractioned ultrafine particles and black carbon associated with autonomic dysfunction in subjects with diabetes or impaired glucose tolerance in Shanghai, China
Sun, Yitong1,2,3; Song, Xiaoming1,2,3; Han, Yiqun4; Ji, Yunfang5; Gao, Shuna5; Shang, Yu6; Lu, Shou-en7; Zhu, Tong4; Huang, Wei1,2,3
关键词Ultrafine particulates Black carbon Traffic pollution Heart rate variability Diabetes Impaired glucose tolerance
刊名PARTICLE AND FIBRE TOXICOLOGY
2015-03-25
DOI10.1186/s12989-015-0084-6
12
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Toxicology
研究领域[WOS]Toxicology
关键词[WOS]HEART-RATE-VARIABILITY ; AMBIENT AIR-POLLUTION ; DIET-INDUCED OBESITY ; CARDIOVASCULAR-DISEASE ; METABOLIC SYNDROME ; ATHEROSCLEROSIS RISK ; EXHAUST INHALATION ; CARDIAC RESPONSES ; FINE PARTICLES ; EXPOSURE
英文摘要

Background: Particles in smaller size fractions, such as ultrafine particles (UFPs) (with diameter less than 100 nm), has become of significant cardiovascular health concerns. However, the biological plausibility underlying potential relationship between UFPs and cardiovascular outcomes is less studied.

Methods: Fifty-three subjects living in Shanghai with type-2 diabetes (T2D) or impaired glucose tolerance (IGT) were followed for autonomic dysfunctions with three repeated measurements in 2010. Minute-to-minute concentrations of ambient particles in small size-fractions (5-560 nm), black carbon (BC), sulfur dioxide (SO2), nitrogen dioxide (NO2), carbon monoxide (CO), and ozone (O-3) were monitored using a central monitoring laboratory equipped with real-time air monitors close to residential area of the subjects. Generalized linear mixed models, with adjustment for individual risk factors, were applied to assess the effects of air pollution on autonomic dysfunctions in subjects.

Results: Our study showed that significant reduction in the standard deviation of all NN intervals (SDNN) ranging from 3.4% to 8.1% were associated with interquartile range (IQR) increase of number concentration of particles (PNC) in size fractions <100 nm, and reduction from 1.3% to 4.6% with particles of diameter 100-200 nm, in subjects with diabetes or glucose tolerance. Increased exposure to traffic-related pollutants BC, NO2 and CO, and combustion pollutant SO2, were also significantly associated with HRV reductions. However, no effect was observed for particles in size fraction of 200-560 nm and O-3. Diabetic risk factor and gender appeared to have significant interactions on autonomic dysfunction associated with UFPs and traffic pollution exposures in certain time-window.

Conclusions: Our results suggest that underlying diabetes or impaired glucose tolerance may confer reduced autonomic function of heart due to traffic pollution exposure.

语种英语
WOS记录号WOS:000354517400001
项目编号2008AA062503 ; 201009032 ; 21190051 ; 2P30ES005022-21
资助机构Ministry of Science and Technology of China ; Ministry of Environmental Protection of China ; National Science Foundation of China ; US National Institute of Environmental Health and Safety
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64411
专题北京大学公共卫生学院
北京大学公共卫生学院_劳动卫生与环境卫生学系
作者单位1.Peking Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth Sci, Beijing 100191, Peoples R China
2.Peking Univ, Sch Publ Hlth, Inst Environm Med, Beijing 100191, Peoples R China
3.Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing 100191, Peoples R China
4.Peking Univ, Coll Environm Sci & Engn, Beijing 100191, Peoples R China
5.Ctr Dis Control & Prevent Luwan Dist, Shanghai, Peoples R China
6.Shanghai Univ, Inst Environm Pollut & Hlth, Shanghai, Peoples R China
7.UMDNJ, Dept Biostat, Sch Publ Hlth, Piscataway, NJ USA
推荐引用方式
GB/T 7714
Sun, Yitong,Song, Xiaoming,Han, Yiqun,et al. Size-fractioned ultrafine particles and black carbon associated with autonomic dysfunction in subjects with diabetes or impaired glucose tolerance in Shanghai, China[J]. PARTICLE AND FIBRE TOXICOLOGY,2015,12.
APA Sun, Yitong.,Song, Xiaoming.,Han, Yiqun.,Ji, Yunfang.,Gao, Shuna.,...&Huang, Wei.(2015).Size-fractioned ultrafine particles and black carbon associated with autonomic dysfunction in subjects with diabetes or impaired glucose tolerance in Shanghai, China.PARTICLE AND FIBRE TOXICOLOGY,12.
MLA Sun, Yitong,et al."Size-fractioned ultrafine particles and black carbon associated with autonomic dysfunction in subjects with diabetes or impaired glucose tolerance in Shanghai, China".PARTICLE AND FIBRE TOXICOLOGY 12(2015).
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Sun, Yitong]的文章
[Song, Xiaoming]的文章
[Han, Yiqun]的文章
百度学术
百度学术中相似的文章
[Sun, Yitong]的文章
[Song, Xiaoming]的文章
[Han, Yiqun]的文章
必应学术
必应学术中相似的文章
[Sun, Yitong]的文章
[Song, Xiaoming]的文章
[Han, Yiqun]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。