IR@PKUHSC  > 北京大学公共卫生学院
学科主题公共卫生
Size-fractioned ultrafine particles and black carbon associated with autonomic dysfunction in subjects with diabetes or impaired glucose tolerance in Shanghai, China
Sun, Yitong1,2,3; Song, Xiaoming1,2,3; Han, Yiqun4; Ji, Yunfang5; Gao, Shuna5; Shang, Yu6; Lu, Shou-en7; Zhu, Tong4; Huang, Wei1,2,3
关键词Ultrafine particulates Black carbon Traffic pollution Heart rate variability Diabetes Impaired glucose tolerance
刊名PARTICLE AND FIBRE TOXICOLOGY
2015-03-25
DOI10.1186/s12989-015-0084-6
12
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Toxicology
资助者Ministry of Science and Technology of China ; Ministry of Environmental Protection of China ; National Science Foundation of China ; US National Institute of Environmental Health and Safety ; Ministry of Science and Technology of China ; Ministry of Environmental Protection of China ; National Science Foundation of China ; US National Institute of Environmental Health and Safety
研究领域[WOS]Toxicology
关键词[WOS]HEART-RATE-VARIABILITY ; AMBIENT AIR-POLLUTION ; DIET-INDUCED OBESITY ; CARDIOVASCULAR-DISEASE ; METABOLIC SYNDROME ; ATHEROSCLEROSIS RISK ; EXHAUST INHALATION ; CARDIAC RESPONSES ; FINE PARTICLES ; EXPOSURE
英文摘要

Background: Particles in smaller size fractions, such as ultrafine particles (UFPs) (with diameter less than 100 nm), has become of significant cardiovascular health concerns. However, the biological plausibility underlying potential relationship between UFPs and cardiovascular outcomes is less studied.

Methods: Fifty-three subjects living in Shanghai with type-2 diabetes (T2D) or impaired glucose tolerance (IGT) were followed for autonomic dysfunctions with three repeated measurements in 2010. Minute-to-minute concentrations of ambient particles in small size-fractions (5-560 nm), black carbon (BC), sulfur dioxide (SO2), nitrogen dioxide (NO2), carbon monoxide (CO), and ozone (O-3) were monitored using a central monitoring laboratory equipped with real-time air monitors close to residential area of the subjects. Generalized linear mixed models, with adjustment for individual risk factors, were applied to assess the effects of air pollution on autonomic dysfunctions in subjects.

Results: Our study showed that significant reduction in the standard deviation of all NN intervals (SDNN) ranging from 3.4% to 8.1% were associated with interquartile range (IQR) increase of number concentration of particles (PNC) in size fractions <100 nm, and reduction from 1.3% to 4.6% with particles of diameter 100-200 nm, in subjects with diabetes or glucose tolerance. Increased exposure to traffic-related pollutants BC, NO2 and CO, and combustion pollutant SO2, were also significantly associated with HRV reductions. However, no effect was observed for particles in size fraction of 200-560 nm and O-3. Diabetic risk factor and gender appeared to have significant interactions on autonomic dysfunction associated with UFPs and traffic pollution exposures in certain time-window.

Conclusions: Our results suggest that underlying diabetes or impaired glucose tolerance may confer reduced autonomic function of heart due to traffic pollution exposure.

语种英语
所属项目编号2008AA062503 ; 201009032 ; 21190051 ; 2P30ES005022-21
资助者Ministry of Science and Technology of China ; Ministry of Environmental Protection of China ; National Science Foundation of China ; US National Institute of Environmental Health and Safety ; Ministry of Science and Technology of China ; Ministry of Environmental Protection of China ; National Science Foundation of China ; US National Institute of Environmental Health and Safety
WOS记录号WOS:000354517400001
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64411
Collection北京大学公共卫生学院
作者单位1.Peking Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth Sci, Beijing 100191, Peoples R China
2.Peking Univ, Sch Publ Hlth, Inst Environm Med, Beijing 100191, Peoples R China
3.Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing 100191, Peoples R China
4.Peking Univ, Coll Environm Sci & Engn, Beijing 100191, Peoples R China
5.Ctr Dis Control & Prevent Luwan Dist, Shanghai, Peoples R China
6.Shanghai Univ, Inst Environm Pollut & Hlth, Shanghai, Peoples R China
7.UMDNJ, Dept Biostat, Sch Publ Hlth, Piscataway, NJ USA
Recommended Citation
GB/T 7714
Sun, Yitong,Song, Xiaoming,Han, Yiqun,et al. Size-fractioned ultrafine particles and black carbon associated with autonomic dysfunction in subjects with diabetes or impaired glucose tolerance in Shanghai, China[J]. PARTICLE AND FIBRE TOXICOLOGY,2015,12.
APA Sun, Yitong.,Song, Xiaoming.,Han, Yiqun.,Ji, Yunfang.,Gao, Shuna.,...&Huang, Wei.(2015).Size-fractioned ultrafine particles and black carbon associated with autonomic dysfunction in subjects with diabetes or impaired glucose tolerance in Shanghai, China.PARTICLE AND FIBRE TOXICOLOGY,12.
MLA Sun, Yitong,et al."Size-fractioned ultrafine particles and black carbon associated with autonomic dysfunction in subjects with diabetes or impaired glucose tolerance in Shanghai, China".PARTICLE AND FIBRE TOXICOLOGY 12(2015).
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
谷歌学术
谷歌学术Similar articles in
[Sun, Yitong]'s Articles
[Song, Xiaoming]'s Articles
[Han, Yiqun]'s Articles
百度学术
百度学术Similar articles in
[Sun, Yitong]'s Articles
[Song, Xiaoming]'s Articles
[Han, Yiqun]'s Articles
必应学术
必应学术Similar articles in
[Sun, Yitong]'s Articles
[Song, Xiaoming]'s Articles
[Han, Yiqun]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.