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学科主题: 基础医学
题名:
Hepatitis E Virus Infection in Farmed Rabbits and Swine in the Eastern Chinese City Lianyungang: Showing no Potential Interspecies Transmission
作者: Han, Jian; Zeng, Hang; Wang, Ling; Liu, Peng; Liu, Lin; Xia, Junke; Zhang, Yulin; Wang, Lin; Zhuang, Hui
关键词: hepatitis E virus (HEV) ; rabbit ; swine ; cross-species transmission ; zoonosis
刊名: JOURNAL OF MEDICAL VIROLOGY
发表日期: 2014-11-01
DOI: 10.1002/jmv.24003
卷: 86, 期:11, 页:1898-1904
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Virology
研究领域[WOS]: Virology
关键词[WOS]: GENETIC IDENTIFICATION ; ZOONOTIC TRANSMISSION ; PHYLOGENETIC ANALYSIS ; FAMILY HEPEVIRIDAE ; UNITED-STATES ; HEV ; GENOTYPE ; JAPAN ; PIGS ; TRANSFUSION
英文摘要:

Rabbit HEV isolated recently from farmed rabbits in China has been shown experimentally to be able to infect both cynomolgus macaques and pigs. The purpose of the present study was to investigate the extent to which cross-species transmission of rabbit HEV in farm settings is a significant factor in the spread of this zoonotic infection. Rabbit and swine feces were collected from the same area in Eastern China (Lianyungang City) and analyzed by RT-PCR. Partial genome sequencing of a 365bp region of ORF2 from the HEV positive rabbit samples revealed that they had 92-99% sequence identity with rabbit strains (rbIM163-c1 and rbIM004) isolated from Inner Mongolia. Similarly, sequencing of a 765bp region of ORF2 of HEV positive swine samples showed 96-98% sequence identity with genotype 4d isolates collected from patients in the Yantai and Nanjing regions of China. By contrast, the sequence identity between the rabbit and swine isolates was only 73-75%, with no molecular biological evidence of interspecies transmission having occurred. It is concluded that whilst interspecies infection with rabbit HEV can be achieved experimentally, in the field it is not a significant factor in zoonotic disease transmission at least in the area of China where this study was undertaken. J. Med. Virol. 86:1898-1904, 2014. (c) 2014 Wiley Periodicals, Inc.

语种: 英语
所属项目编号: 81271827 ; 20120001110098
项目资助者: National Science Foundation of China ; Specialized Research Fund for the Doctoral Program of Higher Education
WOS记录号: WOS:000342681200010
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64413
Appears in Collections:基础医学院_病原生物学系_期刊论文

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作者单位: Peking Univ, Hlth Sci Ctr, Dept Microbiol, Sch Basic Med Sci, Beijing 100191, Peoples R China

Recommended Citation:
Han, Jian,Zeng, Hang,Wang, Ling,et al. Hepatitis E Virus Infection in Farmed Rabbits and Swine in the Eastern Chinese City Lianyungang: Showing no Potential Interspecies Transmission[J]. JOURNAL OF MEDICAL VIROLOGY,2014,86(11):1898-1904.
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