IR@PKUHSC  > 北京大学基础医学院  > 病原生物学系
学科主题基础医学
Hepatitis E Virus Infection in Farmed Rabbits and Swine in the Eastern Chinese City Lianyungang: Showing no Potential Interspecies Transmission
Han, Jian; Zeng, Hang; Wang, Ling; Liu, Peng; Liu, Lin; Xia, Junke; Zhang, Yulin; Wang, Lin; Zhuang, Hui
关键词hepatitis E virus (HEV) rabbit swine cross-species transmission zoonosis
刊名JOURNAL OF MEDICAL VIROLOGY
2014-11-01
DOI10.1002/jmv.24003
86期:11页:1898-1904
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Virology
资助者National Science Foundation of China ; Specialized Research Fund for the Doctoral Program of Higher Education ; National Science Foundation of China ; Specialized Research Fund for the Doctoral Program of Higher Education
研究领域[WOS]Virology
关键词[WOS]GENETIC IDENTIFICATION ; ZOONOTIC TRANSMISSION ; PHYLOGENETIC ANALYSIS ; FAMILY HEPEVIRIDAE ; UNITED-STATES ; HEV ; GENOTYPE ; JAPAN ; PIGS ; TRANSFUSION
英文摘要

Rabbit HEV isolated recently from farmed rabbits in China has been shown experimentally to be able to infect both cynomolgus macaques and pigs. The purpose of the present study was to investigate the extent to which cross-species transmission of rabbit HEV in farm settings is a significant factor in the spread of this zoonotic infection. Rabbit and swine feces were collected from the same area in Eastern China (Lianyungang City) and analyzed by RT-PCR. Partial genome sequencing of a 365bp region of ORF2 from the HEV positive rabbit samples revealed that they had 92-99% sequence identity with rabbit strains (rbIM163-c1 and rbIM004) isolated from Inner Mongolia. Similarly, sequencing of a 765bp region of ORF2 of HEV positive swine samples showed 96-98% sequence identity with genotype 4d isolates collected from patients in the Yantai and Nanjing regions of China. By contrast, the sequence identity between the rabbit and swine isolates was only 73-75%, with no molecular biological evidence of interspecies transmission having occurred. It is concluded that whilst interspecies infection with rabbit HEV can be achieved experimentally, in the field it is not a significant factor in zoonotic disease transmission at least in the area of China where this study was undertaken. J. Med. Virol. 86:1898-1904, 2014. (c) 2014 Wiley Periodicals, Inc.

语种英语
所属项目编号81271827 ; 20120001110098
资助者National Science Foundation of China ; Specialized Research Fund for the Doctoral Program of Higher Education ; National Science Foundation of China ; Specialized Research Fund for the Doctoral Program of Higher Education
WOS记录号WOS:000342681200010
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64413
Collection北京大学基础医学院_病原生物学系
作者单位Peking Univ, Hlth Sci Ctr, Dept Microbiol, Sch Basic Med Sci, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Han, Jian,Zeng, Hang,Wang, Ling,et al. Hepatitis E Virus Infection in Farmed Rabbits and Swine in the Eastern Chinese City Lianyungang: Showing no Potential Interspecies Transmission[J]. JOURNAL OF MEDICAL VIROLOGY,2014,86(11):1898-1904.
APA Han, Jian.,Zeng, Hang.,Wang, Ling.,Liu, Peng.,Liu, Lin.,...&Zhuang, Hui.(2014).Hepatitis E Virus Infection in Farmed Rabbits and Swine in the Eastern Chinese City Lianyungang: Showing no Potential Interspecies Transmission.JOURNAL OF MEDICAL VIROLOGY,86(11),1898-1904.
MLA Han, Jian,et al."Hepatitis E Virus Infection in Farmed Rabbits and Swine in the Eastern Chinese City Lianyungang: Showing no Potential Interspecies Transmission".JOURNAL OF MEDICAL VIROLOGY 86.11(2014):1898-1904.
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