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Studies on aminoisonucleoside modified siRNAs: Stability and silencing activity
Li, Zong-Sheng; Qiao, Ren-Ping; Du, Quan; Yang, Zhen-Jun; Zhang, Liang-Ren; Zhang, Pei-Zhuo; Liang, Zi-Cai; Zhang, Li-He
刊名BIOCONJUGATE CHEMISTRY
2007-07-01
DOI10.1021/bc060398+
18期:4页:1017-1024
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemical Research Methods ; Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary ; Chemistry, Organic
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]SMALL INTERFERING RNA ; CHEMICAL-MODIFICATIONS ; MAMMALIAN-CELLS ; IN-VITRO ; OLIGONUCLEOTIDES ; OLIGODEOXYNUCLEOTIDES ; HYBRIDIZATION ; RECOGNITION ; DUPLEXES ; COMPLEX
英文摘要

A novel class of aminoisonucleoside was synthesized and incorporated into a luciferase gene-targeting siRNA. Structural and functional analyses of such a kind of siRNAs indicated that sense strand modifications with aminoisonucleoside at the 3′ or 5′ terminal, such as ssIso-1 and ssIso-2, have less effect on RNA duplex thermal and serum stabilities, and their functional activities are also comparable to their native siRNAs. In contrast, antisense strand modifications with aminoisonucleoside at the corresponding positions, such as asIso-2 or asIso-1, bring a striking negative effect on RNA duplex stability but still maintain around 40-50% of gene knockdown.

语种英语
WOS记录号WOS:000248085700001
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64415
专题北京大学药学院
作者单位1.Peking Univ, Inst Mol Med, Beijing 100871, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
3.Shanghai GenePharma Co Ltd, ZJ High Tech Pk, Shanghai 201203, Peoples R China
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GB/T 7714
Li, Zong-Sheng,Qiao, Ren-Ping,Du, Quan,et al. Studies on aminoisonucleoside modified siRNAs: Stability and silencing activity[J]. BIOCONJUGATE CHEMISTRY,2007,18(4):1017-1024.
APA Li, Zong-Sheng.,Qiao, Ren-Ping.,Du, Quan.,Yang, Zhen-Jun.,Zhang, Liang-Ren.,...&Zhang, Li-He.(2007).Studies on aminoisonucleoside modified siRNAs: Stability and silencing activity.BIOCONJUGATE CHEMISTRY,18(4),1017-1024.
MLA Li, Zong-Sheng,et al."Studies on aminoisonucleoside modified siRNAs: Stability and silencing activity".BIOCONJUGATE CHEMISTRY 18.4(2007):1017-1024.
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