IR@PKUHSC  > 北京大学基础医学院  > 病原生物学系
学科主题基础医学
Synthesis and characterization of chitosan-based hydrogels
Li, Qianzhu1,2; Yang, Dongzhi1,2; Ma, Guiping1,2; Xu, Qiang3; Chen, Xiangmei3; Lu, Fengmin3; Nie, Jun1,2
关键词Biocompatible Chitosan Photocrosslinking
刊名INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
2009-03-01
DOI10.1016/j.ijbiomac.2008.11.001
44期:2页:121-127
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology
资助者National Natural Science Foundation of China ; Program for Changjiang Scholars and Innovative Research Team in University ; National Natural Science Foundation of China ; Program for Changjiang Scholars and Innovative Research Team in University
研究领域[WOS]Biochemistry & Molecular Biology
关键词[WOS]N-ALKYLATED CHITOSAN ; DRUG-DELIVERY ; CROSS-LINKING ; DERIVATIVES ; COPOLYMERS ; NANOPARTICLES ; MEMBRANE ; SYSTEMS
英文摘要

Biocompatible hydrogels based on water-soluble chitosan-ethylene glycol acrylate methacrylate (CS-EGAMA) and polyethylene glycol diamethacrylate (PEGDMA) were synthesized by photopolymerization. Characterization of morphology, weight loss, water state of hydrogel, pH-sensitivity and cytotoxicity were investigated by scanning electron microscopy (SEM), thermal gravimetric analysis (TGA), X-ray diffraction (XRD), differential scanning calorimetry (DSC), Fourier transform infrared (FTIR), swelling test and methylthiazolydiphenyl-tetrazolium bromide (MTT) assay. The results indicated that the hydrogels were sensitive to pH of the medium, no cytotoxicity for L929 and SW1353, satisfactory for the composite to be used in bioapplications. (C) 2008 Elsevier B.V. All rights reserved.

语种英语
所属项目编号50803004
资助者National Natural Science Foundation of China ; Program for Changjiang Scholars and Innovative Research Team in University ; National Natural Science Foundation of China ; Program for Changjiang Scholars and Innovative Research Team in University
WOS记录号WOS:000263927000001
Citation statistics
Cited Times:31[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64417
Collection北京大学基础医学院_病原生物学系
作者单位1.Beijing Univ Chem Technol, State Key Lab Chem Resource Engn, Beijing 100029, Peoples R China
2.Beijing Univ Chem Technol, Key Lab Beijing City Preparat & Proc Novel Polyme, Beijing 100029, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Beijing 100083, Peoples R China
Recommended Citation
GB/T 7714
Li, Qianzhu,Yang, Dongzhi,Ma, Guiping,et al. Synthesis and characterization of chitosan-based hydrogels[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2009,44(2):121-127.
APA Li, Qianzhu.,Yang, Dongzhi.,Ma, Guiping.,Xu, Qiang.,Chen, Xiangmei.,...&Nie, Jun.(2009).Synthesis and characterization of chitosan-based hydrogels.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,44(2),121-127.
MLA Li, Qianzhu,et al."Synthesis and characterization of chitosan-based hydrogels".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 44.2(2009):121-127.
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