IR@PKUHSC  > 北京大学公共卫生学院
Natural variances in blood pressure category among Chinese adults
Hu, Jihong2,3,4,5; Wu, Yangfeng1,2,3,4; Zhao, Liancheng2,3,4; Li, Ying2,3,4; Zhou, Beifan2,3,4
关键词blood pressure natural changes hypertension intervention Chinese
WOS标题词Science & Technology
类目[WOS]Peripheral Vascular Disease
研究领域[WOS]Cardiovascular System & Cardiology

Little is known about the natural progression and regression of blood pressure status, even though such knowledge would help determine the best intervention strategies. Our study aimed to explore natural changes in blood pressure status in a middle-aged Chinese population. A total of 6,129 Chinese men and women, aged 35 to 59 years at baseline, from the China Multi-center Collaborative Study of Cardiovascular Epidemiology, were reexamined 6 years later to determine the probability of progression (from non-hypertension to hypertension) and regression (from hypertension to non-hypertension). The majority (80%) of non-hypertensives among the respondents in this study remained normal or pre-hypertensive; about two-thirds of stage 1 hypertensives either stayed at the same stage or regressed to non-hypertension. However, only 9% of stage 2 hypertensives regressed to non-hypertension. Multi-variable logistic regression analysis showed that the stage 1 hypertension group had a 5-fold chance of regressing to non-hypertension in comparison with the stage 2 hypertension group (odds ratio [OR] = 0.2, 95% confidence interval [CI]: 0.1-0.3), whereas the pre-hypertension group had a 4-fold likelihood of progressing to hypertension compared with normotensive subjects (OR = 4.4, 95% CI: 3.7-5.3). After excluding participants ever on drug treatment in either examinations, the OR of regression for stage 2 hypertension was over twice that for stage 1 hypertension (OR = 0.5, 95% CI: 0.3-0.7), and the possibility of progression decreased, though very slightly (OR = 4.3, 95% CI: 3.6-5.1). Weight change significantly influenced progression and regression. Alcohol drinking affected progression significantly. In conclusion, the present findings support the strategy of intensively treating stage 2 hypertension and moderately treating stage 1 hypertension. Persons with pre-hypertension should be monitored for progression and advice on lifestyle modifications should be used.

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作者单位1.Ningxia Med Coll, Dept Publ Hlth, Ningxia, Peoples R China
2.Peking Univ, Sch Publ Hlth, Hlth Sci Ctr, Dept Epidemiol & Biostat, Beijing 100083, Peoples R China
3.Chinese Acad Med Sci, Cardiovasc Inst, Dept Epidemiol, Beijing 100037, Peoples R China
4.Chinese Acad Med Sci, Fuwai Hosp, Beijing 100037, Peoples R China
5.Peking Union Med Coll, Beijing 100021, Peoples R China
Recommended Citation
GB/T 7714
Hu, Jihong,Wu, Yangfeng,Zhao, Liancheng,et al. Natural variances in blood pressure category among Chinese adults[J]. HYPERTENSION RESEARCH,2008,31(5):905-911.
APA Hu, Jihong,Wu, Yangfeng,Zhao, Liancheng,Li, Ying,&Zhou, Beifan.(2008).Natural variances in blood pressure category among Chinese adults.HYPERTENSION RESEARCH,31(5),905-911.
MLA Hu, Jihong,et al."Natural variances in blood pressure category among Chinese adults".HYPERTENSION RESEARCH 31.5(2008):905-911.
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