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学科主题: 精神卫生
题名:
Risperidone-induced increase in serum prolactin is correlated with positive symptom improvement in chronic schizophrenia
作者: Zhang, XY; Zhou, DF; Yuan, CL; Zhang, PY; Wu, GY; Shen, YC
关键词: schizophrenia ; prolactin ; dopamine ; antipsychotic drug ; risperidone ; haloperidol
刊名: PSYCHIATRY RESEARCH
发表日期: 2002-04-15
卷: 109, 期:3, 页:297-302
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Psychiatry
研究领域[WOS]: Psychiatry
关键词[WOS]: D-FENFLURAMINE CHALLENGE ; CLINICAL-RESPONSE ; PLASMA PROLACTIN ; ANTIPSYCHOTIC-DRUGS ; RECEPTOR-BINDING ; IN-VITRO ; HALOPERIDOL ; OLANZAPINE ; CLOZAPINE
英文摘要:

The elevation in serum prolactin (PRL) concentration in schizophrenic patients treated with typical antipsychotic drugs is well documented. Recently, increased prolactin levels have been reported in patients taking risperidone. The purpose of this Study was to explore the effect of the atypical antipsychotic drug risperidone on serum prolactin, and to investigate the relationship between the change in PRL and the therapeutic Outcome. In this study, 30 male inpatients with a diagnosis of chronic schizophrenia (DSM-III-R) were assigned to 12 weeks of treatment with risperidone after a 2-week washout period. The risperidone dose was fixed at 6 mg/day. Clinical efficacy was determined using the Positive and Negative Syndrome Scale (PANSS). Serum PRL was assayed in serum by radioimmunometric assay in schizophrenic patients before and after 12-week treatment, as compared to 30 age-matched normal male subjects. The results showed that risperidone treatment significantly increased the serum PRL. A significant and positive relationship between the change in PRL at pre- and post-treatment and the reduction rate of PANSS positive subscore was observed. Risperidone treatment significantly increased the serum PRL levels of schizophrenic patients. There was a close relationship between the improvement in positive symptoms and the change of serum PRL level before and after, risperidone treatment. The serum PRL levels at baseline could be used to predict the responses of schizophrenic patients to risperidone. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000175639700009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64430
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Beijing Huilongguan Hosp, Beijing 100096, Peoples R China
2.Peking Univ, Sch Med, Inst Mental Hlth, Beijing 100871, Peoples R China

Recommended Citation:
Zhang, XY,Zhou, DF,Yuan, CL,et al. Risperidone-induced increase in serum prolactin is correlated with positive symptom improvement in chronic schizophrenia[J]. PSYCHIATRY RESEARCH,2002,109(3):297-302.
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