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Risperidone-induced increase in serum prolactin is correlated with positive symptom improvement in chronic schizophrenia
Zhang, XY; Zhou, DF; Yuan, CL; Zhang, PY; Wu, GY; Shen, YC
关键词schizophrenia prolactin dopamine antipsychotic drug risperidone haloperidol
刊名PSYCHIATRY RESEARCH
2002-04-15
109期:3页:297-302
收录类别SCI ; SSCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Psychiatry
研究领域[WOS]Psychiatry
关键词[WOS]D-FENFLURAMINE CHALLENGE ; CLINICAL-RESPONSE ; PLASMA PROLACTIN ; ANTIPSYCHOTIC-DRUGS ; RECEPTOR-BINDING ; IN-VITRO ; HALOPERIDOL ; OLANZAPINE ; CLOZAPINE
英文摘要

The elevation in serum prolactin (PRL) concentration in schizophrenic patients treated with typical antipsychotic drugs is well documented. Recently, increased prolactin levels have been reported in patients taking risperidone. The purpose of this Study was to explore the effect of the atypical antipsychotic drug risperidone on serum prolactin, and to investigate the relationship between the change in PRL and the therapeutic Outcome. In this study, 30 male inpatients with a diagnosis of chronic schizophrenia (DSM-III-R) were assigned to 12 weeks of treatment with risperidone after a 2-week washout period. The risperidone dose was fixed at 6 mg/day. Clinical efficacy was determined using the Positive and Negative Syndrome Scale (PANSS). Serum PRL was assayed in serum by radioimmunometric assay in schizophrenic patients before and after 12-week treatment, as compared to 30 age-matched normal male subjects. The results showed that risperidone treatment significantly increased the serum PRL. A significant and positive relationship between the change in PRL at pre- and post-treatment and the reduction rate of PANSS positive subscore was observed. Risperidone treatment significantly increased the serum PRL levels of schizophrenic patients. There was a close relationship between the improvement in positive symptoms and the change of serum PRL level before and after, risperidone treatment. The serum PRL levels at baseline could be used to predict the responses of schizophrenic patients to risperidone. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000175639700009
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被引频次:21[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64430
专题北京大学精神卫生研究所
作者单位1.Beijing Huilongguan Hosp, Beijing 100096, Peoples R China
2.Peking Univ, Sch Med, Inst Mental Hlth, Beijing 100871, Peoples R China
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GB/T 7714
Zhang, XY,Zhou, DF,Yuan, CL,et al. Risperidone-induced increase in serum prolactin is correlated with positive symptom improvement in chronic schizophrenia[J]. PSYCHIATRY RESEARCH,2002,109(3):297-302.
APA Zhang, XY,Zhou, DF,Yuan, CL,Zhang, PY,Wu, GY,&Shen, YC.(2002).Risperidone-induced increase in serum prolactin is correlated with positive symptom improvement in chronic schizophrenia.PSYCHIATRY RESEARCH,109(3),297-302.
MLA Zhang, XY,et al."Risperidone-induced increase in serum prolactin is correlated with positive symptom improvement in chronic schizophrenia".PSYCHIATRY RESEARCH 109.3(2002):297-302.
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