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学科主题: 药学
题名:
Initial dosage regimens of vancomycin for Chinese adult patients based on population pharmacokinetic analysis
作者: Deng, Chenhui1,2; Liu, Taotao3; Zhou, Tianyan1,2; Lu, Hua3; Cheng, Daohai3; Zhong, Xiaobing3; Lu, Wei1,2
关键词: vancomycin ; Chinese adult patients ; population pharmacokinetics ; NONMEM ; steady-state trough concentrations
刊名: INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS
发表日期: 2013-05-01
DOI: 10.5414/CP201842
卷: 51, 期:5, 页:407-415
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: CRITICALLY-ILL PATIENTS ; RESISTANT STAPHYLOCOCCUS-AUREUS ; ANTIBIOTIC-THERAPY ; SERUM CREATININE ; RENAL-FUNCTION ; NEPHROTOXICITY ; INFECTIONS ; OUTCOMES
英文摘要:

Objective: To build a population pharmacokinetic model for Chinese adult patients and develop initial dosage regimens for patients with different degrees of renal function to achieve target steady-state trough concentrations in the range of 10 - 15 and 15 - 20 mg/l. Method: Data on serum vancomycin concentration was collected from a retrospective study including 72 Chinese adult patients. NON-MEM was used to build the population pharmacokinetic model, and a one-compartment model was chosen to describe the vancomycin concentration-time profile. Internal evaluation by bootstrap and visual predictive check (VPC) was performed to evaluate the robustness and prediction of the final model. Monte Carlo simulations were conducted to develop initial dosage regimens to achieve target trough concentrations. Results: A one-compartment model was built with creatinine clearance (CLcr) as the key covariate influencing drug clearance. The estimated drug clearance for patients with normal renal function (CLcr >= 80 ml/min) was 4.90 1/h, and 0.0654 x CLcr if CLcr was < 80 ml/min. The apparent volume of the central compartment was 47.76 1 and no covariate was found to affect it. The results of bootstrap analysis were in agreement with the original parameters of the final model, and VPC of the final model demonstrated good predictability. Initial dosage regimens were developed based on the simulations of the population pharmacokinetic model. Conclusion: A one-compartment model fitted the retrospective data and CLcr had a significant effect on drug clearance. Initial dosage regimens for vancomycin were proposed to provide some help to individual therapy for Chinese adult patients with different renal functions.

语种: 英语
WOS记录号: WOS:000320839600008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64440
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
3.Guangxi Med Univ, Affiliated Hosp 1, Guangxi, Peoples R China

Recommended Citation:
Deng, Chenhui,Liu, Taotao,Zhou, Tianyan,et al. Initial dosage regimens of vancomycin for Chinese adult patients based on population pharmacokinetic analysis[J]. INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS,2013,51(5):407-415.
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