北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 基础医学院  > 免疫学系  > 期刊论文
学科主题: 基础医学
题名:
Differential expression of MST4, STK25 and PDCD10 between benign prostatic hyperplasia and prostate cancer
作者: Zhang, Heyu1,3,4; Ma, Xi5; Peng, Saihui1,3; Nan, Xu2,3; Zhao, Hongshan2,3
关键词: MST4 ; STK25 ; PDCD10 ; benign prostatic hyperplasia ; prostate cancer
刊名: INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
发表日期: 2014
卷: 7, 期:11, 页:8105-8111
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Pathology
研究领域[WOS]: Oncology ; Pathology
关键词[WOS]: CEREBRAL CAVERNOUS MALFORMATIONS ; MITOGEN-ACTIVATED PROTEIN ; APOPTOSIS-RELATED GENE ; STE20-RELATED KINASE ; OXIDATIVE STRESS ; GCKIII PROTEINS ; CELL-GROWTH ; INTERACTS ; GOLGI ; TRANSFORMATION
英文摘要:

Both benign prostatic hyperplasia (BPH) and prostate cancer (PC) are common diseases for men around the world. Both serine/threonine protein kinase MST4 (MST4) and serine/threonine kinase 25 (STK25) belong to the Ste20-like kinases and interact with programmed cell death 10 (PDCD10) which is closely linked to cancer diseases. To clarify the roles of MST4, STK25 and PDCD10 in prostate carcinogenesis, we examined MST4, STK25 and PDCD10 expression in tissue microarray blocks containing 110 cores of BPH and 160 cores of PC immunohistochemically and evaluated their correlation with clinicopathological findings. MST4 was not expressed in all the BPH cases and expressed in 38.7% of PC cases (P < 0.0001). STK25 expression was found in 77.3% of BPH cases and 93.1% of PC cases (P < 0.0001). PDCD10 staining was considered weak in 82 (74.5%) and strong in 28 (25.5%) of BPH cases. However, in prostate cancer cases, PDCD10 staining was weak in 95 (59.4%) and strong in 65 (40.6%) (P < 0.05). PDCD10 and STK25 immunostaining were associated with age in prostatic hyperplasia cases (P < 0.05). The staining intensity for STK25 was significantly greater in Gleason grades 3-5 (47.1% of such cases staining strongly) compared with other grades of prostate cancer (only 26.5% of these cases staining strongly; P < 0.05). Our results suggest that MST4, STK25 and PDCD10 are unregulated in prostate cancer and may play roles in prostate tumorigenesis. MST4 may be a helpful marker for identifying prostate cancer.

语种: 英语
所属项目编号: 30872940 ; 81300894
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000348345200092
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64446
Appears in Collections:基础医学院_免疫学系_期刊论文

Files in This Item:
File Name/ File Size Content Type Version Access License
ijcep0007-8105.pdf(655KB)期刊论文出版稿限制开放 联系获取全文

作者单位: 1.Peking Univ, Sch Basic Med Sci, Dept Immunol, Beijing 100871, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Med Genet, Beijing 100871, Peoples R China
3.Peking Univ, Human Dis Genom Ctr, Beijing 100871, Peoples R China
4.Peking Univ, Sch Stomatol, Cent Lab, Beijing 100871, Peoples R China
5.China Agr Univ, State Key Lab Anim Nutr, Beijing 100193, Peoples R China

Recommended Citation:
Zhang, Heyu,Ma, Xi,Peng, Saihui,et al. Differential expression of MST4, STK25 and PDCD10 between benign prostatic hyperplasia and prostate cancer[J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY,2014,7(11):8105-8111.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zhang, Heyu]'s Articles
[Ma, Xi]'s Articles
[Peng, Saihui]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zhang, Heyu]‘s Articles
[Ma, Xi]‘s Articles
[Peng, Saihui]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace