|Reduced Cerebrovascular Reactivity in Posterior Cerebral Arteries in Patients with Primary Open-Angle Glaucoma|
|Zhang, Shaodan1,2; Xie, Yuan3; Yang, Jie4; Tang, Yangshuo4; Li, Ruoxi2; Wang, Ningli3; Zhang, Chun1|
|WOS标题词||Science & Technology|
|关键词[WOS]||LATERAL GENICULATE-NUCLEUS ; NORMAL-TENSION GLAUCOMA ; VISUAL-FIELD DEFECTS ; GANGLION-CELL LOSS ; BLOOD-FLOW ; CORTEX ; BRAIN ; PROGRESSION ; DENSITY ; NUMBER|
Purpose: To evaluate the hemodynamics and vasoreactivity in the posterior cerebral artery (PCA) in patients with primary open-angle glaucoma (POAG).
Design: Case-control study.
Participants: Thirteen POAG patients (age range, 40-60 years) with marked visual field loss (mean deviation [MD], < -6 dB); a preserved, mostly normal, central visual field of at least 5 degrees; and best-corrected visual acuity of at least 20/40 formed the study group. Exclusion criterion was presence or history of any systemic disorder including cardiovascular diseases. The control group consisted of 12 healthy subjects matched for age and sex with the study group.
Methods: Applying transcranial Doppler sonography, we measured hemodynamic parameters in both PCAs at baseline, under monocular reversing checkerboard stimulation, and under hyperventilation. The eye with more marked visual field loss was selected in glaucoma patients, whereas in controls, the tested eye was chosen randomly. Ipsilateral and contralateral PCA were defined according to the tested eye.
Main Outcome Measures: Peak systolic velocity (PSV), end-diastolic velocity, mean velocity (MV), MV change percentage (MV%), resistivity index (RI), pulsatility index (PI).
Results: At baseline, RI (0.55 +/- 0.04 vs. 0.52 +/- 0.03; P = 0.04) and PI (0.88 +/- 0.11 vs. 0.80 +/- 0.07; P = 0.04) in the ipsilateral PCA were significantly higher in glaucoma patients than in controls. During checkerboard stimulation, MV% in both PCAs were significantly smaller in the glaucoma group than in controls (19.7 +/- 7.2% and 19.0 +/- 8.3% vs. 30.7 +/- 7.9% and 27.5 +/- 9.0%, respectively; P = 0.001 and 0.02, respectively). During hyperventilation, glaucoma patients showed significantly lower MV% in the contralateral PCA than control subjects (-39.8 +/- 9.6% versus -47.4 +/- 7.0%; P = 0.03). Perimetric pattern standard deviation (PSD) in the tested eye was correlated significantly with RI and PI of the ipsilateral PCA during checkerboard stimulation (P = 0.003, r = -0.76; and P = 0.002, r = -0.76). The MV% of contralateral PCA was correlated inversely with PSD in the fellow eye (P = 0.02, r = -0.64). The difference in MV% between both PCAs was correlated positively with the difference in MD between 2 eyes (P = 0.003, r = 0.75). Under hyperventilation, PSV in the contralateral PCA was correlated negatively with the PSD in the fellow eye (P = 0.03, r = -0.60).
Conclusions: Vascular insufficiency in the PCAs may be associated with POAG. Changes in the vasoreactivity of PCAs to central visual stimulation may precede marked central visual field loss. (C) 2013 by the American Academy of Ophthalmology.
|项目编号||20100480170 ; 81100661 ; 2010YKSJ04|
|资助机构||Postdoctoral Science Foundation of China ; National Nature Science Foundation of China ; Key Lab Open Foundation of Capital Medical University, Beijing, China|
|作者单位||1.Peking Univ, Hosp 3, Dept Ophthalmol, Hlth Sci Ctr, Beijing 100871, Peoples R China|
2.4th Peoples Hosp Shenyang, Dept Ophthalmol, Shenyang Eye Res Inst, Key Lab Ophthalmol Shenyang, Shenyang, Peoples R China
3.Capital Med Univ, Beijing TongRen Hosp, Beijing TongRen Eye Ctr, Beijing 100730, Peoples R China
4.Capital Med Univ, Beijing Xuanwu Hosp, Dept Vasc Ultrasonag, Beijing 100730, Peoples R China
|Zhang, Shaodan,Xie, Yuan,Yang, Jie,et al. Reduced Cerebrovascular Reactivity in Posterior Cerebral Arteries in Patients with Primary Open-Angle Glaucoma[J]. OPHTHALMOLOGY,2013,120(12):2501-2507.|
|APA||Zhang, Shaodan.,Xie, Yuan.,Yang, Jie.,Tang, Yangshuo.,Li, Ruoxi.,...&Zhang, Chun.(2013).Reduced Cerebrovascular Reactivity in Posterior Cerebral Arteries in Patients with Primary Open-Angle Glaucoma.OPHTHALMOLOGY,120(12),2501-2507.|
|MLA||Zhang, Shaodan,et al."Reduced Cerebrovascular Reactivity in Posterior Cerebral Arteries in Patients with Primary Open-Angle Glaucoma".OPHTHALMOLOGY 120.12(2013):2501-2507.|