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学科主题: 临床医学
题名:
Expressions of miR-15a and its target gene HSPA1B in the spermatozoa of patients with varicocele
作者: Ji, Ziliang1,2,3; Lu, Ruijing1,2,4; Mou, Lisha1,3; Duan, Yong-Gang1,3; Zhang, Qiang1; Wang, Yadong1; Gui, Yaoting1; Cai, Zhiming1
刊名: REPRODUCTION
发表日期: 2014-05-01
DOI: 10.1530/REP-13-0656
卷: 147, 期:5, 页:693-701
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Developmental Biology ; Reproductive Biology
研究领域[WOS]: Developmental Biology ; Reproductive Biology
关键词[WOS]: HEAT-SHOCK PROTEINS ; MOUSE EPIDIDYMAL SPERMATOZOA ; ALTERED MICRORNA EXPRESSION ; REJECTION ANTIGEN GP96 ; MALE-INFERTILITY ; MOLECULAR CHAPERONES ; REPRODUCTIVE-TRACT ; OXIDATIVE STRESS ; HUMAN TESTIS ; SPERMATOGENESIS
英文摘要:

Hyperthermia and oxidative stresses are the two central elements contributing to varicocele-related sperm damage. Growing evidence indicates that microRNAs (miRNAs) are involved in the regulation of the heat and oxidative stress responses. In this study, we analyzed the expressions of several stress-related miRNAs in the sperm and found that the expression of miR-15a was significantly decreased in patients with varicocele compared with the control. Furthermore, miR-15a repressed the expression of HSPA1B, which is a typical stress-induced chaperone protein, through directly binding its 3′-UTR. The expressions of miR-15a and HSPA1B exhibited an inverse correlation in sperm. Our results provide a valuable insight into the varicocele-related sperm impairment and male infertility, and may help to develop potential therapeutic targets and novel biomarkers for male infertility.

语种: 英语
所属项目编号: 2011CB944303 ; 31271244 ; 81200465 ; CXB201104220045A ; 201202001 ; 201302053
项目资助者: National Key Scientific Program of China ; National Natural Science Foundation of China ; Shenzhen Foundation of Science and Technology
WOS记录号: WOS:000336898100017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64453
Appears in Collections:北京大学深圳医院_期刊论文

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作者单位: 1.Shantou Univ, Coll Med, Shantou 515041, Peoples R China
2.Peking Univ, Guangdong & Shenzhen Key Lab Male Reprod Med & Ge, Shenzhen PKU HKUST Med Ctr, Inst Urol,Shenzhen Hosp, Shenzhen 518036, Peoples R China
3.Shenzhen Univ, Affiliated Hosp 1, Shenzhen Peoples Hosp 2, Ctr Reprod Med & Androl, Shenzhen 518035, Peoples R China
4.Peking Univ, Shenzhen Hosp, Dept Clin Lab, Shenzhen 518036, Peoples R China

Recommended Citation:
Ji, Ziliang,Lu, Ruijing,Mou, Lisha,et al. Expressions of miR-15a and its target gene HSPA1B in the spermatozoa of patients with varicocele[J]. REPRODUCTION,2014,147(5):693-701.
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