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A randomized, open-label, multicentre study to evaluate plasma atherosclerotic biomarkers in patients with type 2 diabetes mellitus and arteriosclerosis obliterans when treated with Probucol and Cilostazol
Ma, Xiao-Wei1; Guo, Xiao-Hui1; Xiao, Xin-Hua2; Guo, Li-Xin3; Lv, Xiao-Feng4; Li, Quan-Min5; Gao, Yan1
关键词Cilostazol Probucol Combination treatment Atherosclerosis Biomarkers Synergetic effect
刊名JOURNAL OF GERIATRIC CARDIOLOGY
2012
DOI10.3724/SP.J.1263.2012.02143
9期:3页:228-236
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cardiac & Cardiovascular Systems ; Geriatrics & Gerontology
资助者Otsuka Beijing Research Institute ; Otsuka Beijing Research Institute
研究领域[WOS]Cardiovascular System & Cardiology ; Geriatrics & Gerontology
关键词[WOS]LOW-DENSITY-LIPOPROTEIN ; PHOSPHODIESTERASE INHIBITOR ; CAROTID ATHEROSCLEROSIS ; CARDIOVASCULAR-DISEASE ; CONCURRENT TREATMENT ; ENDOTHELIAL-CELLS ; CHOLESTEROL ; HYPERCHOLESTEROLEMIA ; TRIAL ; COMBINATION
英文摘要

Objectives To evaluate the plasma atherosclerotic biomarkers in patients with type 2 diabetes mellitus (T2DM) and arteriosclerosis obliteran (ASO) when treated with Probucol plus Cilostazol in combination and individually. Methods In this open-label study, patients aged 40-75 years were randomized to receive conventional therapy alone, or with Cilostazol 100 mg bid, or with Probucol 250 mg bid, or with both in combination. Endpoints included changes in plasma biomarker and safety at 12 weeks. Results Of the 200 randomized patients, 165 for per-protocol and 160 for the safety (QTc intervals) were set, respectively. Probucol significantly reduced total cholesterol (P < 0.001), low-density lipoprotein cholesterol (LDL-C), (P = 0.01), and high-density lipoprotein cholesterol (HDL-C) (P < 0.001) compared with conventional therapy. Cilostazol was effective in increasing HDL-C (P = 0.002) and reducing triglycerides levels (P < 0.01) compared with conventional therapy. A trend towards significance was observed for the difference between conventional therapy alone and Probucol plus Cilostazol group for the change in oxidized low-density lipoprotein (Ox-LDL, P = 0.065). No significant effects on the majority of the remaining biomarkers were found across the treatment groups. Conclusions We have confirmed that Ox-LDL could be a possible plasma atherosclerotic biomarker among the evaluated biomarkers, which reflected the synergetic effect of Cilostazol plus Probucol in patients with T2DM and ASO shown previously in preclinical studies.

语种英语
资助者Otsuka Beijing Research Institute ; Otsuka Beijing Research Institute
WOS记录号WOS:000309522000003
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64454
专题北京大学第一临床医学院_内分泌内科
作者单位1.Peking Hosp, Dept Endocrinol, Beijing 100730, Peoples R China
2.Peking Univ, Hosp 1, Dept Endocrinol, Beijing 100034, Peoples R China
3.Beijing Union Med Coll Hosp, Dept Endocrinol, Beijing 100005, Peoples R China
4.Peking PLA, Dept Endocrinol, Mil Gen Hosp, Beijing 100070, Peoples R China
5.Peking PLA, Artillery Forces Gen Hosp 2, Dept Endocrinol, Beijing 100088, Peoples R China
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GB/T 7714
Ma, Xiao-Wei,Guo, Xiao-Hui,Xiao, Xin-Hua,et al. A randomized, open-label, multicentre study to evaluate plasma atherosclerotic biomarkers in patients with type 2 diabetes mellitus and arteriosclerosis obliterans when treated with Probucol and Cilostazol[J]. JOURNAL OF GERIATRIC CARDIOLOGY,2012,9(3):228-236.
APA Ma, Xiao-Wei.,Guo, Xiao-Hui.,Xiao, Xin-Hua.,Guo, Li-Xin.,Lv, Xiao-Feng.,...&Gao, Yan.(2012).A randomized, open-label, multicentre study to evaluate plasma atherosclerotic biomarkers in patients with type 2 diabetes mellitus and arteriosclerosis obliterans when treated with Probucol and Cilostazol.JOURNAL OF GERIATRIC CARDIOLOGY,9(3),228-236.
MLA Ma, Xiao-Wei,et al."A randomized, open-label, multicentre study to evaluate plasma atherosclerotic biomarkers in patients with type 2 diabetes mellitus and arteriosclerosis obliterans when treated with Probucol and Cilostazol".JOURNAL OF GERIATRIC CARDIOLOGY 9.3(2012):228-236.
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