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学科主题: 临床医学
题名:
Androgen receptor coregulator ARA267-alpha interacts with death receptor-6 revealed by the yeast two-hybrid
作者: Mai, TJ; Wang, X; Zhang, ZW; Xin, DQ; Na, YQ; Guo, YL
关键词: ARA267-alpha ; androgen receptor ; androgen receptor coregulator ; death receptor-6 ; yeast two-hybrid system
刊名: SCIENCE IN CHINA SERIES C-LIFE SCIENCES
发表日期: 2004-10-01
DOI: 10.1360/03yc0214
卷: 47, 期:5, 页:442-448
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biology
研究领域[WOS]: Life Sciences & Biomedicine - Other Topics
关键词[WOS]: ACUTE MYELOID-LEUKEMIA ; DOMAIN-CONTAINING GENE ; PROSTATE-CANCER CELLS ; SET DOMAIN ; TNF RECEPTOR ; NSD1 ; IDENTIFICATION ; EXPRESSION ; HORMONE ; NUP98
英文摘要:

ARA267-alpha is a newly identified androgen receptor coactivator. In order to further elucidate its precise role in cells, using the ARA267-alpha fragment containing four PHD and one SET conserved domains as bait we revealed an ARA267-alpha-PHD-SET-interacting protein, death receptor-6 (DR6), in the yeast two-hybrid screening. DR6 is the member of TNF receptor family and has a death domain in its intracellular cytoplasmic portion (DR6cp) to mediate the cell apoptosis. The interaction between ARA267-a-PHD-SET and DR6cp was confirmed in vitro and in vivo. Our finding implied that androgen signaling pathway might cross talk with apoptosis signaling pathway through the interaction between ARA267-a and DR6.

语种: 英语
WOS记录号: WOS:000225425200007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64455
Appears in Collections:北京大学第一临床医学院_普通外科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Gen Surg, Beijing 100034, Peoples R China
2.Peking Univ, Hosp 1, Inst Urol, Beijing 100034, Peoples R China
3.Peking Univ, Dept Physiol, Beijing 100083, Peoples R China

Recommended Citation:
Mai, TJ,Wang, X,Zhang, ZW,et al. Androgen receptor coregulator ARA267-alpha interacts with death receptor-6 revealed by the yeast two-hybrid[J]. SCIENCE IN CHINA SERIES C-LIFE SCIENCES,2004,47(5):442-448.
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