IR@PKUHSC  > 北京大学精神卫生研究所
学科主题精神卫生
Adjunctive benzodiazepine treatment of hospitalized schizophrenia patients in Asia from 2001 to 2008
Tor, Phern-Chern1; Ng, Tze Pin1; Yong, Kian-Hui2; Sim, Kang2; Xiang, Yu-Tao3,4; Wang, Chuan-Yue3; Lee, Edwin Ho Ming4; Fujii, Senta5; Yang, Shu-yu6; Chong, Mian-Yoon7,8; Ungvari, Gabor S.9; Si, Tianmei10; He, Yan Ling11; Chung, Eun Kee12; Chee, Kok-Yoon13; Trivedi, Jintendra14; Udomratn, Pichet15; Shinfuku, Naotaka16; Kua, Ee Heok1; Tan, Chay Hoon1; Sartorius, Norman17; Baldessarini, Ross J.18
关键词Adverse effects antipsychotics Asian benzodiazepines polytherapy schizophrenia
刊名INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
2011-07-01
DOI10.1017/S146114571000163X
14期:6页:735-745
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Clinical Neurology ; Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
研究领域[WOS]Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]LONG-TERM USE ; PSYCHOTROPIC-DRUG PRESCRIPTION ; SEVERE MENTAL-ILLNESS ; EAST-ASIA ; FOLLOW-UP ; NATIONAL-SURVEY ; PREDICTORS ; DISCONTINUATION ; DISORDER ; PATTERNS
英文摘要

Benzodiazepines are commonly prescribed to patients with schizophrenia in many countries, but as little is known about such treatment in Asia, we evaluated their adjunctive use for 6761 in-patients diagnosed with schizophrenia in nine Asian countries using a cross-sectional study design in 2001, 2004 and 2008. Multivariate logistic regression and multivariate linear regression analyses were performed to assess predictors of benzodiazepine use and dose, respectively. Overall, 54% of the patients received adjunctive benzodiazepines at an average daily dose equivalent to 30.3 mg diazepam, with minor changes over the years sampled. Benzodiazepine use was highest in Taiwan and Japan, lowest in Thailand and China, and was associated with fewer years ill, presence of delusions (OR 1.24), hallucinations (OR 1.22), disorganized speech (OR 1.17), social or occupational dysfunction (OR 1.16), and use of mood stabilizers (OR 3.15), antiparkinsonian (OR 1.79) or antidepressant drugs (OR 1.33), and lower doses of antipsychotics (all p = 0.016 to < 0.001). Benzodiazepine doses were highest in Taiwan and China, lowest in Korea and Singapore; higher doses were associated with being young, male, physically aggressive, receiving mood stabilizers, and having electroconvulsive treatment (all p = 0.019 to < 0.001). Benzodiazepine use was associated with neurological and systemic adverse effects. In conclusion, benzodiazepine use was common in Asian patients with schizophrenia. Predictors of benzodiazepine use and dose differed in this population. Critical clinical guidelines should be developed specifically for Asian countries to address sound practices in regard to use of benzodiazepines for psychotic disorders.

语种英语
WOS记录号WOS:000291611000002
Citation statistics
Cited Times:15[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64459
Collection北京大学精神卫生研究所
作者单位1.Natl Univ Singapore Hosp, Singapore 117548, Singapore
2.Woodbridge Hosp, Inst Mental Hlth, Singapore, Singapore
3.Hyogo Inst Traumat Stress, Kobe, Hyogo, Japan
4.Taipei City Hosp, Taipei, Taiwan
5.Chang Gung Mem Hosp, Kaohsiung Med Ctr, Kaohsiung, Taiwan
6.Chang Gung Univ, Coll Med, Kaohsiung, Taiwan
7.Peking Univ, Inst Mental Hlth, Beijing, Peoples R China
8.Shanghai Mental Hlth Ctr, Shanghai, Peoples R China
9.Seoul Natl Hosp, Seoul, South Korea
10.King George Med Univ, Lucknow, Uttar Pradesh, India
11.Capital Med Univ, Beijing Anding Hosp, Beijing, Peoples R China
12.Chinese Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China
13.Univ Western Australia, Sch Psychiat & Clin Neurosci, Perth, WA 6009, Australia
14.Kuala Lumpur Hosp, Tunku Abdul Rahman Inst Neurosci, Dept Psychiat & Mental Hlth, Kuala Lumpur, Malaysia
15.Seo Prince Songkla Univ, Songkhla, Thailand
16.Seinan Gakuin Univ, Fukuoka, Japan
17.Univ Geneva, Geneva, Switzerland
18.Harvard Univ, Sch Med, McLean Hosp, Boston, MA USA
Recommended Citation
GB/T 7714
Tor, Phern-Chern,Ng, Tze Pin,Yong, Kian-Hui,et al. Adjunctive benzodiazepine treatment of hospitalized schizophrenia patients in Asia from 2001 to 2008[J]. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY,2011,14(6):735-745.
APA Tor, Phern-Chern.,Ng, Tze Pin.,Yong, Kian-Hui.,Sim, Kang.,Xiang, Yu-Tao.,...&Baldessarini, Ross J..(2011).Adjunctive benzodiazepine treatment of hospitalized schizophrenia patients in Asia from 2001 to 2008.INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY,14(6),735-745.
MLA Tor, Phern-Chern,et al."Adjunctive benzodiazepine treatment of hospitalized schizophrenia patients in Asia from 2001 to 2008".INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY 14.6(2011):735-745.
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