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学科主题: 临床医学
题名:
Simvastatin treatment improves functional recovery after experimental spinal cord injury by upregulating the expression of BDNF and GDNF
作者: Han, Xiaoguang2; Yang, Ning2; Xu, Yingsheng1; Zhu, Jinglin2; Chen, Zhongqiang2; Liu, Zhongjun2; Dang, Gengting2; Song, Chunli2
关键词: Spinal cord injury ; Simvastatin ; Electrophysiology ; Neurotrophin
刊名: NEUROSCIENCE LETTERS
发表日期: 2011-01-10
DOI: 10.1016/j.neulet.2010.09.007
卷: 487, 期:3, 页:255-259
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: TRAUMATIC BRAIN-INJURY ; NEUROGENESIS ; ATORVASTATIN ; INCREASE ; CELLS ; RATS ; TRANSPLANTATION ; OVEREXPRESSION ; ACTIVATION ; SURVIVAL
英文摘要:

The aim of this study was to determine the therapeutic efficacy of simvastatin treatment starting 1 day after spinal cord injury (SCI) in rat and to investigate the underlying mechanism. Spinal cord injury was induced in adult female Sprague-Dawley rats after laminectomy at T9-T10. Then additionally with sham group (laminectomy only) the SCI animals were randomly divided into 3 groups: vehicle-treated group; 5-mg/kg simvastatin-treated group; and 10-mg/kg simvastatin-treated group. Simvastatin or vehicle was administered orally at 1 day after SCI and then daily for 5 weeks. Locomotor functional recovery was assessed during 8 weeks postoperation by performing open-field locomotor test and inclined-plane test. At the end of study, motor evoked potentials (MEPs) and somatosensory evoked potentials (SEPs) were assessed to evaluate the integrity of spinal cord pathways. Then, the animals were killed, and 1-cm segments of spinal cord encompassing the injury site were removed for histopathological analysis. Immunohistochemistry was performed to observe the expression of brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF) in the spinal cord. Results show that the simvastatin-treated animals showed significantly better locomotor function recovery, better electrophysiological outcome, less myelin loss, and higher expression of BDNF and GDNF. These findings suggest that simvastatin treatment starting 1 day after SCI can significantly improve locomotor recovery, and this neuro protective effect may be related to the upregulation of BDNF and GDNF. Therefore, simvastatin may be useful as a promising therapeutic agent for SCI. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
所属项目编号: 30300352 ; 30772200
项目资助者: National Nature Science Foundation of China
WOS记录号: WOS:000286697400001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64460
Appears in Collections:北京大学第三临床医学院_神经内科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Dept Neurol, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Dept Orthoped, Beijing 100191, Peoples R China

Recommended Citation:
Han, Xiaoguang,Yang, Ning,Xu, Yingsheng,et al. Simvastatin treatment improves functional recovery after experimental spinal cord injury by upregulating the expression of BDNF and GDNF[J]. NEUROSCIENCE LETTERS,2011,487(3):255-259.
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