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学科主题临床医学
Human papillomavirus type 16 is an important infectious factor in the high incidence of esophageal cancer in Anyang area of China
Li, T; Lu, ZM; Chen, KN; Guo, M; Xing, HP; Mei, Q; Yang, HH; Lechner, JF; Ke, Y
刊名CARCINOGENESIS
2001-06-01
22期:6页:929-934
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]SQUAMOUS-CELL CARCINOMAS ; POLYMERASE CHAIN-REACTION ; INSITU HYBRIDIZATION ; DNA ; LESIONS ; TRANSCRIPTS ; MICROSCOPY ; ABSENCE ; SENSE
英文摘要

To investigate the potential role of human papillomavirus (HPV) infection in the pathogenesis of esophageal carcinomas in the Anyang area of China, we have evaluated specimens collected by balloon cytology examination from volunteers in two regions with significantly different incidences of esophageal carcinoma. 138 donors were from a village in a county with an esophageal carcinoma (EC) age-adjusted mortality rate of 132 x 10(5), the remaining 68 were resident in a second village from another county with an EC mortality rate of 52 x 10(5). Specimens were evaluated using both polymerase chain reaction (PCR) amplification and irt situ hybridization (ISH) protocols, PCR results showed that the prevalence of the human papillomavirus type 16 (HPV-16) Ed gene in the high incidence area was 1.9-fold higher than that of the low incidence area (72 and 37%, respectively, P < 0.01). Moreover, the positive rate corresponded with pathology grade. Similar results were obtained with the HPV-16 E7 gene. As the cells undergoing cytopathological progress, the HPV-16 E6 positive rate was increased, in both villages, In contrast to HPV-16 Ed and E7, detection of the HPV L1 gene was consistently lower, and its prevalence decreased with increasing dysplasia grades (P < 0.05), By ISH analyses, the expression rate of HPV-16 Ed in the specimens collected from the high incidence area was 2.2-fold higher than those from the low incidence area (49 versus 22%, respectively; P < 0.05), and transcription of the Ed gene paralleled cytopathology, HPV-18 was also detected in 17 and 15% of the specimens from the high and low incidence areas, respectively, but most of these samples were also simultaneously HVP-16 positive. These results suggest that HVP-16 plays a causative role in the high incidence of esophageal cancer in the Anyang region of China.

语种英语
WOS记录号WOS:000169171500014
引用统计
被引频次:80[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64463
专题北京大学临床肿瘤学院_遗传学研究室
作者单位1.Peking Univ, Sch Oncol, Bejing Inst Canc Res, Genet Lab, Beijing 100034, Peoples R China
2.Anyang Tumor Hosp, Anyang City 455000, Peoples R China
3.Wayne State Univ, Karmanos Canc Inst, Detroit, MI 48201 USA
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GB/T 7714
Li, T,Lu, ZM,Chen, KN,et al. Human papillomavirus type 16 is an important infectious factor in the high incidence of esophageal cancer in Anyang area of China[J]. CARCINOGENESIS,2001,22(6):929-934.
APA Li, T.,Lu, ZM.,Chen, KN.,Guo, M.,Xing, HP.,...&Ke, Y.(2001).Human papillomavirus type 16 is an important infectious factor in the high incidence of esophageal cancer in Anyang area of China.CARCINOGENESIS,22(6),929-934.
MLA Li, T,et al."Human papillomavirus type 16 is an important infectious factor in the high incidence of esophageal cancer in Anyang area of China".CARCINOGENESIS 22.6(2001):929-934.
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