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学科主题: 临床医学
题名:
Apoptosis index correlates with chemotherapy efficacy and predicts the survival of patients with gastric cancer
作者: Jia, Yongning1; Dong, Bin2; Tang, Lei3; Liu, Yiqiang2; Du, Hong1; Yuan, Peng1; Wu, Aiwen1; Ji, Jiafu1
关键词: Gastric cancer ; Neoadjuvant chemotherapy ; Apoptosis index ; Gastrectomy
刊名: TUMOR BIOLOGY
发表日期: 2012-08-01
DOI: 10.1007/s13277-012-0357-8
卷: 33, 期:4, 页:1151-1158
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: HELICOBACTER-PYLORI INFECTION ; ESTROGEN-RECEPTOR STATUS ; EPITHELIAL APOPTOSIS ; RESPONSE EVALUATION ; SOLID TUMORS ; CARCINOMA ; ERADICATION ; MUCOSA ; PROLIFERATION ; INDUCTION
英文摘要:

The objectives of this study are to investigate the apoptotic changes in gastric adenocarcinoma following neoadjuvant chemotherapy and to illuminate its correlation with response. One 67 gastric cancer patients with cT2-4 or TanyN1-3M0 between January 2006 and December 2007 were included. All patients had previous gastrectomy and D2 lymphadenectomy with curative intent performed. A total of 12 cycles of preoperative mFOLFOX7 chemotherapy was recommended for all patients, and 83 patients received only adjuvant chemotherapy. Resected specimens were subjected to in situ TUNEL assay and scanned with Applied Imaging Ariol SL-50. Apoptosis index (AI) was significantly higher in the patient received preoperative chemotherapy (CS group) than in the patient did not (S group). In the CS group, AI was found to have a strong positive correlation with the pathological response (rho = 0.403, P = 0.0002). A ROC curve presented a score of 49.4 as the AI cutoff value for response, dividing the CS group into two subgroups with significantly different prognoses (P = 0.003) and further allowing identification of 8 patients with significantly better prognosis out of 48 patients evaluated as grades 1a-b according to a pathological response evaluation (P = 0.022). In conclusion, AI is correlated with efficacy of preoperative chemotherapy and prognosis of gastric cancer patients following neoadjuvant chemotherapy. An AI cutoff value for response may be used as a complementary approach to current pathological response evaluations to help identify potential responders.

语种: 英语
所属项目编号: 81071983 ; 2007B-057
项目资助者: Natural Science Foundation of China ; Beijing Municipal Science &amp ; Technology Commission NOVA
WOS记录号: WOS:000306731500029
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64464
Appears in Collections:北京大学临床肿瘤学院_胃肠肿瘤中心_期刊论文

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作者单位: 1.Peking Univ, Canc Hosp & Inst, Dept Gastrointestinal Surg, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China
2.Peking Univ, Canc Hosp & Inst, Dept Pathol, Beijing 100142, Peoples R China
3.Peking Univ, Canc Hosp & Inst, Dept Radiol, Beijing 100142, Peoples R China

Recommended Citation:
Jia, Yongning,Dong, Bin,Tang, Lei,et al. Apoptosis index correlates with chemotherapy efficacy and predicts the survival of patients with gastric cancer[J]. TUMOR BIOLOGY,2012,33(4):1151-1158.
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