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学科主题临床医学
Apoptosis index correlates with chemotherapy efficacy and predicts the survival of patients with gastric cancer
Jia, Yongning1; Dong, Bin2; Tang, Lei3; Liu, Yiqiang2; Du, Hong1; Yuan, Peng1; Wu, Aiwen1; Ji, Jiafu1
关键词Gastric cancer Neoadjuvant chemotherapy Apoptosis index Gastrectomy
刊名TUMOR BIOLOGY
2012-08-01
DOI10.1007/s13277-012-0357-8
33期:4页:1151-1158
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
资助者Natural Science Foundation of China ; Beijing Municipal Science &amp ; Technology Commission NOVA ; Natural Science Foundation of China ; Beijing Municipal Science &amp ; Technology Commission NOVA
研究领域[WOS]Oncology
关键词[WOS]HELICOBACTER-PYLORI INFECTION ; ESTROGEN-RECEPTOR STATUS ; EPITHELIAL APOPTOSIS ; RESPONSE EVALUATION ; SOLID TUMORS ; CARCINOMA ; ERADICATION ; MUCOSA ; PROLIFERATION ; INDUCTION
英文摘要

The objectives of this study are to investigate the apoptotic changes in gastric adenocarcinoma following neoadjuvant chemotherapy and to illuminate its correlation with response. One 67 gastric cancer patients with cT2-4 or TanyN1-3M0 between January 2006 and December 2007 were included. All patients had previous gastrectomy and D2 lymphadenectomy with curative intent performed. A total of 12 cycles of preoperative mFOLFOX7 chemotherapy was recommended for all patients, and 83 patients received only adjuvant chemotherapy. Resected specimens were subjected to in situ TUNEL assay and scanned with Applied Imaging Ariol SL-50. Apoptosis index (AI) was significantly higher in the patient received preoperative chemotherapy (CS group) than in the patient did not (S group). In the CS group, AI was found to have a strong positive correlation with the pathological response (rho = 0.403, P = 0.0002). A ROC curve presented a score of 49.4 as the AI cutoff value for response, dividing the CS group into two subgroups with significantly different prognoses (P = 0.003) and further allowing identification of 8 patients with significantly better prognosis out of 48 patients evaluated as grades 1a-b according to a pathological response evaluation (P = 0.022). In conclusion, AI is correlated with efficacy of preoperative chemotherapy and prognosis of gastric cancer patients following neoadjuvant chemotherapy. An AI cutoff value for response may be used as a complementary approach to current pathological response evaluations to help identify potential responders.

语种英语
所属项目编号81071983 ; 2007B-057
资助者Natural Science Foundation of China ; Beijing Municipal Science &amp ; Technology Commission NOVA ; Natural Science Foundation of China ; Beijing Municipal Science &amp ; Technology Commission NOVA
WOS记录号WOS:000306731500029
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64464
专题北京大学临床肿瘤学院_胃肠肿瘤中心
作者单位1.Peking Univ, Canc Hosp & Inst, Dept Gastrointestinal Surg, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China
2.Peking Univ, Canc Hosp & Inst, Dept Pathol, Beijing 100142, Peoples R China
3.Peking Univ, Canc Hosp & Inst, Dept Radiol, Beijing 100142, Peoples R China
推荐引用方式
GB/T 7714
Jia, Yongning,Dong, Bin,Tang, Lei,et al. Apoptosis index correlates with chemotherapy efficacy and predicts the survival of patients with gastric cancer[J]. TUMOR BIOLOGY,2012,33(4):1151-1158.
APA Jia, Yongning.,Dong, Bin.,Tang, Lei.,Liu, Yiqiang.,Du, Hong.,...&Ji, Jiafu.(2012).Apoptosis index correlates with chemotherapy efficacy and predicts the survival of patients with gastric cancer.TUMOR BIOLOGY,33(4),1151-1158.
MLA Jia, Yongning,et al."Apoptosis index correlates with chemotherapy efficacy and predicts the survival of patients with gastric cancer".TUMOR BIOLOGY 33.4(2012):1151-1158.
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