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学科主题: 口腔医学
题名:
Effects of Anhydroicaritin and 2 ′′-Hydroxy-3 ′′-en-anhydroicaritin on the Proliferation and Differentiation of MC3T3-E1 Osteoblasts
作者: Li, Yanping1,2; Zhang, Xuehui1; Peng, Hui1; Li, Rongtao2; Deng, Xuliang1
关键词: Anhydroicaritin ; 2 &prime ; &prime ; -Hydroxy-3 &prime ; &prime ; -en-anhydroicaritin ; Proliferation ; Differentiation ; Bone regenerative medicine
刊名: NATURAL PRODUCT COMMUNICATIONS
发表日期: 2012-11-01
卷: 7, 期:11, 页:1461-1464
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal ; Food Science & Technology
研究领域[WOS]: Pharmacology & Pharmacy ; Food Science & Technology
关键词[WOS]: EPIMEDIUM-BREVICORNUM ; FLAVONOL GLYCOSIDES ; BONE ; CELLS ; RABBITS ; MAXIM
英文摘要:

Epimedium brevicornu Maxim., one of the most frequently used traditional Chinese medicines for thousands of years, is prescribed as having "bone strengthening function and the ability to cure bone diseases. The present study evaluated the osteogenic effects of anhydroicaritin (I) and 2 ′′-hydroxy-3 ′′-enanhydroicaritin (2) isolated from E. brevicornu by activity-guided assay. Treatment with1 and 2 improved the proliferation of murine osteoblastic MC3T3-E1 cells at doses of 10(-7)-10(-5) mol/L and 10(-7)-10(-6) mol/L, respectively, in the 72-hour culture period. Enzyme linked immunosorbent assay and histochemical staining demonstrated that both of these two prenyl-flavonoids significantly promoted the differentiation of MC3T3-E1 cells by enhancing the level of ALP activity in the cells. Alizarin Red staining and mineralized nodule quantification showed that I and 2 had the potential of stimulating the formation of mineralization nodules and further speeding up the formation of bone, indicating that both compounds might be potential candidates for bone regenerative medicine.

语种: 英语
所属项目编号: 21062008 ; 21262021 ; 81171000 ; 2010DFA51500 ; 2012CB933904
项目资助者: National Natural Science Foundation of China ; International Science and Technology Cooperation Program ; National Major Scientific Research Program
WOS记录号: WOS:000311663700013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64465
Appears in Collections:北京大学口腔医学院_期刊论文

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作者单位: 1.Peking Univ, Sch & Hosp Stomatol, Dept Geriatr Dent, Beijing 100081, Peoples R China
2.Kunming Univ Sci & Technol, Fac Life Sci & Technol, Kunming 650500, Yunnan, Peoples R China

Recommended Citation:
Li, Yanping,Zhang, Xuehui,Peng, Hui,et al. Effects of Anhydroicaritin and 2 ′′-Hydroxy-3 ′′-en-anhydroicaritin on the Proliferation and Differentiation of MC3T3-E1 Osteoblasts[J]. NATURAL PRODUCT COMMUNICATIONS,2012,7(11):1461-1464.
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