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Effects of Anhydroicaritin and 2 ′′-Hydroxy-3 ′′-en-anhydroicaritin on the Proliferation and Differentiation of MC3T3-E1 Osteoblasts
Li, Yanping1,2; Zhang, Xuehui1; Peng, Hui1; Li, Rongtao2; Deng, Xuliang1
关键词Anhydroicaritin 2 &prime &prime -Hydroxy-3 &prime &prime -en-anhydroicaritin Proliferation Differentiation Bone regenerative medicine
刊名NATURAL PRODUCT COMMUNICATIONS
2012-11-01
7期:11页:1461-1464
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal ; Food Science & Technology
研究领域[WOS]Pharmacology & Pharmacy ; Food Science & Technology
关键词[WOS]EPIMEDIUM-BREVICORNUM ; FLAVONOL GLYCOSIDES ; BONE ; CELLS ; RABBITS ; MAXIM
英文摘要

Epimedium brevicornu Maxim., one of the most frequently used traditional Chinese medicines for thousands of years, is prescribed as having "bone strengthening function and the ability to cure bone diseases. The present study evaluated the osteogenic effects of anhydroicaritin (I) and 2 ′′-hydroxy-3 ′′-enanhydroicaritin (2) isolated from E. brevicornu by activity-guided assay. Treatment with1 and 2 improved the proliferation of murine osteoblastic MC3T3-E1 cells at doses of 10(-7)-10(-5) mol/L and 10(-7)-10(-6) mol/L, respectively, in the 72-hour culture period. Enzyme linked immunosorbent assay and histochemical staining demonstrated that both of these two prenyl-flavonoids significantly promoted the differentiation of MC3T3-E1 cells by enhancing the level of ALP activity in the cells. Alizarin Red staining and mineralized nodule quantification showed that I and 2 had the potential of stimulating the formation of mineralization nodules and further speeding up the formation of bone, indicating that both compounds might be potential candidates for bone regenerative medicine.

语种英语
WOS记录号WOS:000311663700013
项目编号21062008 ; 21262021 ; 81171000 ; 2010DFA51500 ; 2012CB933904
资助机构National Natural Science Foundation of China ; International Science and Technology Cooperation Program ; National Major Scientific Research Program
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64465
专题北京大学口腔医学院
北京大学第一临床医学院_超声诊断中心
北京大学口腔医学院_特诊科
北京大学口腔医学院_第三门诊部
作者单位1.Peking Univ, Sch & Hosp Stomatol, Dept Geriatr Dent, Beijing 100081, Peoples R China
2.Kunming Univ Sci & Technol, Fac Life Sci & Technol, Kunming 650500, Yunnan, Peoples R China
推荐引用方式
GB/T 7714
Li, Yanping,Zhang, Xuehui,Peng, Hui,et al. Effects of Anhydroicaritin and 2 ′′-Hydroxy-3 ′′-en-anhydroicaritin on the Proliferation and Differentiation of MC3T3-E1 Osteoblasts[J]. NATURAL PRODUCT COMMUNICATIONS,2012,7(11):1461-1464.
APA Li, Yanping,Zhang, Xuehui,Peng, Hui,Li, Rongtao,&Deng, Xuliang.(2012).Effects of Anhydroicaritin and 2 ′′-Hydroxy-3 ′′-en-anhydroicaritin on the Proliferation and Differentiation of MC3T3-E1 Osteoblasts.NATURAL PRODUCT COMMUNICATIONS,7(11),1461-1464.
MLA Li, Yanping,et al."Effects of Anhydroicaritin and 2 ′′-Hydroxy-3 ′′-en-anhydroicaritin on the Proliferation and Differentiation of MC3T3-E1 Osteoblasts".NATURAL PRODUCT COMMUNICATIONS 7.11(2012):1461-1464.
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