IR@PKUHSC  > 北京大学第二临床医学院
学科主题临床医学
Spontaneous Production of Immunoglobulin M in Human Epithelial Cancer Cells
Hu, Fanlei1,2; Zhang, Li2; Zheng, Jie2; Zhao, Ling3; Huang, Jing2; Shao, Wenwei2; Liao, Qinyuan2; Ma, Teng2; Geng, Li3; Yin, C. Cameron4; Qiu, Xiaoyan2
刊名PLOS ONE
2012-12-12
DOI10.1371/journal.pone.0051423
7期:12
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]TOLL-LIKE RECEPTOR-9 ; NF-KAPPA-B ; NASOPHARYNGEAL CARCINOMA-CELLS ; CHAIN CONSTANT-REGION ; ALPHA HEAVY-CHAIN ; CPG DNA ; MESSENGER-RNA ; TUMOR-CELLS ; MOLECULAR-PATTERNS ; CELLULAR INVASION
英文摘要

It is well known that B-1 B cells are the main cell type that is responsible for the production of natural immunoglobulin M (IgM) and can respond to infection by increasing IgM secretion. However, we unexpectedly found that some epithelial cells also can express rearranged IgM transcript that has natural IgM characteristics, such as germline-encoded and restricted rearrangement patterns. Here we studied IgM expression in human non-B cells and found that IgM was frequently expressed by many human epithelial cancer cells as well as non-cancer epithelial cells. Moreover, CD79A and CD79B, two molecules that are physically linked to membranous IgM on the surface of B cells to form the B cell antigen receptor complex, were also expressed on the cell surface of epithelial cancer cells and co-located with IgM. Like the natural IgM, the epithelial cancer cell-derived IgM recognized a series of microbial antigens, such as single-stranded DNA, double-stranded DNA, lipopolysaccharide, and the HEp-2 cell antigen. More important, stimulation of the toll-like receptor 9 (TLR9), which mimics bacterial infection, substantially increased the secretion of IgM in human epithelial cancer cells. These findings indicate that human epithelial cancer cells as well as non-cancer epithelial cells can spontaneously produce IgM with natural antibody activity.

语种英语
WOS记录号WOS:000313236200104
项目编号30973389 ; 30772470
资助机构National Natural Science Foundation of China
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64466
专题北京大学第二临床医学院
北京大学基础医学院
北京大学医学图书馆_流通阅览部
北京大学第三临床医学院_妇产科
作者单位1.Peking Univ, Peoples Hosp, Dept Rheumatol & Immunol, Beijing 100871, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Immunol, Beijing 100871, Peoples R China
3.Peking Univ, Hosp 3, Dept Gynaecol, Beijing 100871, Peoples R China
4.Univ Texas MD Anderson Canc Ctr, Dept Hematopathol, Houston, TX 77030 USA
推荐引用方式
GB/T 7714
Hu, Fanlei,Zhang, Li,Zheng, Jie,et al. Spontaneous Production of Immunoglobulin M in Human Epithelial Cancer Cells[J]. PLOS ONE,2012,7(12).
APA Hu, Fanlei.,Zhang, Li.,Zheng, Jie.,Zhao, Ling.,Huang, Jing.,...&Qiu, Xiaoyan.(2012).Spontaneous Production of Immunoglobulin M in Human Epithelial Cancer Cells.PLOS ONE,7(12).
MLA Hu, Fanlei,et al."Spontaneous Production of Immunoglobulin M in Human Epithelial Cancer Cells".PLOS ONE 7.12(2012).
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