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学科主题: 临床医学
题名:
Spontaneous Production of Immunoglobulin M in Human Epithelial Cancer Cells
作者: Hu, Fanlei1,2; Zhang, Li2; Zheng, Jie2; Zhao, Ling3; Huang, Jing2; Shao, Wenwei2; Liao, Qinyuan2; Ma, Teng2; Geng, Li3; Yin, C. Cameron4; Qiu, Xiaoyan2
刊名: PLOS ONE
发表日期: 2012-12-12
DOI: 10.1371/journal.pone.0051423
卷: 7, 期:12
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: TOLL-LIKE RECEPTOR-9 ; NF-KAPPA-B ; NASOPHARYNGEAL CARCINOMA-CELLS ; CHAIN CONSTANT-REGION ; ALPHA HEAVY-CHAIN ; CPG DNA ; MESSENGER-RNA ; TUMOR-CELLS ; MOLECULAR-PATTERNS ; CELLULAR INVASION
英文摘要:

It is well known that B-1 B cells are the main cell type that is responsible for the production of natural immunoglobulin M (IgM) and can respond to infection by increasing IgM secretion. However, we unexpectedly found that some epithelial cells also can express rearranged IgM transcript that has natural IgM characteristics, such as germline-encoded and restricted rearrangement patterns. Here we studied IgM expression in human non-B cells and found that IgM was frequently expressed by many human epithelial cancer cells as well as non-cancer epithelial cells. Moreover, CD79A and CD79B, two molecules that are physically linked to membranous IgM on the surface of B cells to form the B cell antigen receptor complex, were also expressed on the cell surface of epithelial cancer cells and co-located with IgM. Like the natural IgM, the epithelial cancer cell-derived IgM recognized a series of microbial antigens, such as single-stranded DNA, double-stranded DNA, lipopolysaccharide, and the HEp-2 cell antigen. More important, stimulation of the toll-like receptor 9 (TLR9), which mimics bacterial infection, substantially increased the secretion of IgM in human epithelial cancer cells. These findings indicate that human epithelial cancer cells as well as non-cancer epithelial cells can spontaneously produce IgM with natural antibody activity.

语种: 英语
所属项目编号: 30973389 ; 30772470
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000313236200104
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64466
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Dept Rheumatol & Immunol, Beijing 100871, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Immunol, Beijing 100871, Peoples R China
3.Peking Univ, Hosp 3, Dept Gynaecol, Beijing 100871, Peoples R China
4.Univ Texas MD Anderson Canc Ctr, Dept Hematopathol, Houston, TX 77030 USA

Recommended Citation:
Hu, Fanlei,Zhang, Li,Zheng, Jie,et al. Spontaneous Production of Immunoglobulin M in Human Epithelial Cancer Cells[J]. PLOS ONE,2012,7(12).
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