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学科主题: 临床医学
题名:
Different HCV Genotype Distributions of HIV-Infected Individuals in Henan and Guangxi, China
作者: Tian, Di1; Li, Lin2; Liu, Yongjian2; Li, Hanping2; Xu, Xiaoyuan1; Li, Jingyun2
刊名: PLOS ONE
发表日期: 2012-11-30
DOI: 10.1371/journal.pone.0050343
卷: 7, 期:11
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: HEPATITIS-C VIRUS ; LIVER-ENZYME ELEVATION ; INJECTION-DRUG USERS ; BLOOD-DONORS ; COINFECTION ; MANAGEMENT ; EPIDEMIOLOGY ; PREVALENCE ; PATIENT ; YUNNAN
英文摘要:

Background: Due to shared transmission routes, hepatitis C virus (HCV) infection is highly prevalent among people infected with human immunodeficiency virus (HIV). Highly active antiretroviral therapy (HAART) is associated with hepatotoxicity, leading to the negative effects on patients with HIV/HCV co-infection. In order to provide valuable information for HCV management in this particular population, we investigated the HCV genotypes in HIV-infected individuals from Henan and Guangxi, the two provinces with the most HIV-infected cases in China.

Methods: Individuals, who acquired HIV infection through various risk routes, were recruited from Henan and Guangxi. Test of antibodies against HCV (anti-HCV) was conducted, and detection of HCV RNA was performed by PCR amplification. HCV subtypes were determined by direct sequencing of amplicons, followed by phylogenetic analysis.

Results: We recruited a total of 1,112 HIV-infected people in this present study. Anti-HCV was detected from 218 (50.1%) patients from Henan and 81 (12.0%) patients from Guangxi, respectively. The highest prevalence of HIV/HCV co-infection was observed from FBDs (former blood donors) (87.2%) in Henan and IDUs (intravenous drug users) (81.8%) in Guangxi, respectively. The seroprevalence rate of HCV among people with sexual contact was significantly higher in Henan than in Guangxi (18.7% vs. 3.5%, P<0.05). The positive rate of HCV RNA in Henan and Guangxi was 30.6% (133/435) and 11.2% (76/677), respectively. Moreover, we found that 20 anti-HCV negative samples were HCV positive by PCR amplification. HCV subtype 1b (52.7%) was predominant in Henan, followed by subtype 2a (41.9%). The most frequently detected subtypes in Guangxi were 6a (35.6%) and 3b (32.9%).

Conclusion: The HCV genotype distributions were different in HIV-infected people from Henan and Guangxi. HIV/HCV co-infection was not only linked to the transmission routes, but also associated with the geographic position.

语种: 英语
所属项目编号: 2008ZX10001-004 ; 2008ZX10002-013 ; 20090001110081
项目资助者: 11th Five-Year Plan ; Specialized Research Fund for the Doctoral Program of Higher Education (SRFDP)
WOS记录号: WOS:000312376100075
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64471
Appears in Collections:北京大学第一临床医学院_感染疾病科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Infect Dis, Beijing 100871, Peoples R China
2.Beijing Inst Microbiol & Epidemiol, Dept AIDS Res, State Key Lab Pathogen & Biosecur, Beijing, Peoples R China

Recommended Citation:
Tian, Di,Li, Lin,Liu, Yongjian,et al. Different HCV Genotype Distributions of HIV-Infected Individuals in Henan and Guangxi, China[J]. PLOS ONE,2012,7(11).
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