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学科主题: 药学
题名:
Three new eudesmane sesquiterpenes from Artemisia vestita
作者: Tian, Shuai-Hua1; Chai, Xing-Yun2; Zan, Ke1; Zeng, Ke-Wu1; Tu, Peng-Fei1
关键词: Artemisia vestita ; Eudesmane sesquiterpene ; Artemivestinolide ; X-ray diffraction
刊名: CHINESE CHEMICAL LETTERS
发表日期: DOI: 10.1016/j.cclet.2013.05.020
卷: 24, 期:9, 页:797-800
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
关键词[WOS]: NATURAL SESQUITERPENOIDS ; DIMERIC GUAIANOLIDES ; LACTONES ; ANOMALA
英文摘要:

Three eudesmane sesquiterpene lactones, namely artemivestinolides A-C (1-3), along with three known 11-epimeric lactones (4-6), were isolated from the aerial parts of Artemisia vestita. Their structures were elucidated on the basis of extensive spectroscopic analyses (IR, HR-ESIMS, 1D NMR and 2D NMR), and the absolute configurations were determined by single-crystal X-ray diffraction (with copper radiation). Furthermore, in an in vitro assay, the three new compounds exhibited a moderate inhibition of the lipopolysaccharide (LPS)-induced nitric oxide (NO) production in BV-2 microglial cells. (C) 2013 Peng-Fei Tu. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

语种: 英语
所属项目编号: 30973629 ; 2012ZX09301002-002-002 ; 2012ZX09304-005
项目资助者: National Natural Science Foundation of China ; National Key Technology R&amp ; D Program "New Drug Innovation" of China
WOS记录号: WOS:000323589600008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64477
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Hlth Sci Ctr, Beijing 100191, Peoples R China
2.Beijing Univ Chinese Med, Modern Res Ctr Tradit Chinese Med, Beijing 100029, Peoples R China

Recommended Citation:
Tian, Shuai-Hua,Chai, Xing-Yun,Zan, Ke,et al. Three new eudesmane sesquiterpenes from Artemisia vestita[J]. CHINESE CHEMICAL LETTERS,2013,24(9):797-800.
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