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学科主题: 临床医学
题名:
p63 expression in ovarian tumours: a marker for Brenner tumours but not transitional cell carcinomas
作者: Liao, X. Y.; Xue, W. C.; Shen, D. H.; Ngan, H. Y. S.; Siu, M. K.; Cheung, A. N.
关键词: Brenner tumour ; ovarian tumours ; p63 ; transitional cell carcinoma
刊名: HISTOPATHOLOGY
发表日期: 2007-10-01
DOI: 10.1111/j.1365-2559.2007.02804.x
卷: 51, 期:4, 页:477-483
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology ; Pathology
研究领域[WOS]: Cell Biology ; Pathology
关键词[WOS]: UROTHELIAL DIFFERENTIATION ; MYOEPITHELIAL CELLS ; TISSUE MICROARRAY ; P53 HOMOLOG ; DIAGNOSIS ; BLADDER ; LESIONS ; TRACT ; BASAL ; PROLIFERATION
英文摘要:

Aims: To investigate p63 expression in ovarian neoplasms.

Methods and results: Immunohistochemistry using an antibody that detects all p63 isoforms was performed on 103 primary ovarian neoplasms of different histological types. Diffuse nuclear immunoreactivity of p63 was demonstrated in the 17 benign and five borderline Brenner tumours. Only one of the six malignant Brenner tumours displayed p63 expression. p63 immunoreactivity was absent in all the ovarian transitional cell carcinomas (TCC), but was demonstrated extensively in TCCs of the urinary bladder. Besides focal p63 expression in epidermal basal cells of immature and mature teratomas, all other ovarian lesions were devoid of p63 expression. p63 expression was also demonstrated in cervical transitional cell metaplasia and Walthard cell nests of fallopian tubes.

Conclusions: Expression of p63 protein is apparently cell lineage specific and in ovarian neoplasms is confined to benign and borderline Brenner tumours. The loss of expression in malignant Benner tumours suggests a role for p63 in Brenner carcinogenesis. The distinct patterns of p63 expression in TCCs in the ovary and urinary bladder may help in their differential diagnosis.

语种: 英语
WOS记录号: WOS:000249661900006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64482
Appears in Collections:北京大学第二临床医学院_病理科_期刊论文

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作者单位: 1.Univ Hong Kong, Queen Mary Hosp, Dept Pathol, Hong Kong, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Pathol, Beijing 100871, Peoples R China
3.Univ Hong Kong, Dept Obstet & Gynaecol, Hong Kong, Peoples R China

Recommended Citation:
Liao, X. Y.,Xue, W. C.,Shen, D. H.,et al. p63 expression in ovarian tumours: a marker for Brenner tumours but not transitional cell carcinomas[J]. HISTOPATHOLOGY,2007,51(4):477-483.
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