北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学药学院  > 期刊论文
学科主题: 药学
题名:
In vitro and in vivo characterization of a newly developed clonidine transdermal patch for treatment of attention deficit hyperactivity disorder in children
作者: Ke, GM; Wang, L; Xue, HY; Lu, WL; Zhang, X; Zhang, QA; Guo, HY
关键词: clonidine ; KBD-transdermal therapeutic system (TTS) ; LC-MS ; transdermal penetration ; pharmacokinetics ; rabbit
刊名: BIOLOGICAL & PHARMACEUTICAL BULLETIN
发表日期: 2005-02-01
卷: 28, 期:2, 页:305-310
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: HEALTHY-SUBJECTS ; MASS-SPECTROMETRY ; HUMAN-PLASMA ; PHARMACOKINETICS ; M-5041T ; PHARMACODYNAMICS ; CHROMATOGRAPHY
英文摘要:

The aim of this study was to characterize a newly developed clonidine transdermal patch, KBD-transdermal therapeutic system (TTS), for the treatment of attention deficit hyperactivity disorder in children. fit vitro release, penetration, and in vivo pharmacokinetics in rabbits were investigated. The smaller size of KBD-TTS (2.5 mg/2.5 cm(2)) showed a similar in vitro penetration to those of Catapres-TTS (2.5 mg/3.5 cm(2), a clonidine transdermal patch used for the treatment of hypertension, Alza Corporation, U.S.A.). The transdermal penetration rate of clonidine was mainly controlled by the ethylene vinylacetate membrane used in the patch. The skin layer may be only a minor rate-limiting barrier after the topical skin layer at the dosing site is saturated with penetrating clonidine in the initial phase (0 to 12 h). A sensitive liquid chromatography-mass spectrometry method for the quantification of clonidine in rabbit plasma was developed using solid-phase extraction and gradient elution on LC combined with the selected-ion monitoring (SIM) mode. A single dose of clonidine transdermal patch (KBD-TTS) or Catapres-TTS was transdermally administered to rabbits (n = 6 each) and removed after 168 h. The average half-life, T-max, C-max, and C-ss values of clonidine in rabbits following administration of KBD-TTS were 19.27 +/- 4.68 h, 52.56 +/- 25.77 h, 27.39 +/- 9.03 ng/ml, and 25.82 +/- 9.34 ng/ml, similar to those of Catapres-TTS, respectively. The clonidine plasma concentration of KBD-TTS reached a steady state at 24 h through 168 h. The in vitro release rate of the clonidine from KBD-TTS significantly correlated with the in vivo absorption rate (p < 0.001).

语种: 英语
WOS记录号: WOS:000226995300022
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64485
Appears in Collections:北京大学药学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Beijing Kangbeide Pharmaceut Ltd, Beijing 100089, Peoples R China
2.Beijing Univ Chem Technol, Coll Sci, Beijing 100029, Peoples R China
3.Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China

Recommended Citation:
Ke, GM,Wang, L,Xue, HY,et al. In vitro and in vivo characterization of a newly developed clonidine transdermal patch for treatment of attention deficit hyperactivity disorder in children[J]. BIOLOGICAL &amp; PHARMACEUTICAL BULLETIN,2005,28(2):305-310.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Ke, GM]'s Articles
[Wang, L]'s Articles
[Xue, HY]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Ke, GM]‘s Articles
[Wang, L]‘s Articles
[Xue, HY]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace