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Neurobehavioral effects of human immunodeficiency virus infection among former plasma donors in rural China
Heaton, Robert K.1; Cysique, Lucette A.1; Jin, Hua1,2; Shi, Chuan3; Yu, Xin3; Letendre, Scott1; Franklin, Donald R., Jr.1; Ake, Christopher1; Vigil, Ofilio1; Atkinson, J. Hampton1; Marcotte, Thomas D.1; Grant, Igor1; Wu, Zunyou4; San Diego HIV Neurobehav Res Ctr G
关键词HIV HCV neurocognitive disorders China
刊名JOURNAL OF NEUROVIROLOGY
2008-12-01
DOI10.1080/13550280802378880
14期:6页:536-549
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences ; Virology
研究领域[WOS]Neurosciences & Neurology ; Virology
关键词[WOS]HEPATITIS-C VIRUS ; NERVOUS-SYSTEM INVOLVEMENT ; WORLD-HEALTH-ORGANIZATION ; SUB-SAHARAN AFRICA ; HIV-INFECTION ; NEUROPSYCHOLOGICAL IMPAIRMENT ; ANTIRETROVIRAL THERAPY ; NEUROCOGNITIVE IMPAIRMENT ; NEUROPSYCHIATRIC AIDS ; COGNITIVE IMPAIRMENT
英文摘要

The human immunodeficiency virus (HIV) epidemic in China has expanded rapidly in recent years, but little is known about the prevalence and features of HIV-associated neurocognitive disorders (HANDs) in this part of the world. We administered a comprehensive Western neuropsychological (NP) test battery to 203 HIV+ and 198 HIV - former plasma donors in the rural area of Anhui province. They found that 26% of the HIV - samples, and 46% of the HIV+ samples, were infected with hepatitis C virus (HCV), which can also have central nervous system (CNS) effects. To classify NP impairment, we developed demographically corrected test norms based upon individuals free of both infections (N = 141). Using a global summary score, NP impairment was found in 34.2% of the HIV-monoinfected group and 39.7% of the coinfected group, as compared to 12.7% of the uninfected controls (P < .001). HIV+ participants with acquired immunodeficiency syndrome (AIDS) were more likely to be impaired (43%) than non-AIDS individuals (29%; P < .05). Lastly, when all infection groups were combined, participants with NP impairment reported more cognitive complaints (P < .01) and increased dependence in everyday functioning (P = .01). In sum, NP impairment in this large rural Chinese sample was associated with both HIV and HCV infections, and the impairment′s prevalence, severity, and pattern were

语种英语
WOS记录号WOS:000262851400009
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被引频次:39[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64497
专题北京大学精神卫生研究所
北京大学精神卫生研究所_精神科
作者单位1.Natl Ctr AIDS STD Control & Prevent NCAIDS, Beijing, Peoples R China
2.VA San Diego Hlth Care Syst, San Diego, CA USA
3.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
4.Univ Calif San Diego, Dept Psychiat, HIV Neurobehav Res Ctr HNRC, La Jolla, CA 92093 USA
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GB/T 7714
Heaton, Robert K.,Cysique, Lucette A.,Jin, Hua,et al. Neurobehavioral effects of human immunodeficiency virus infection among former plasma donors in rural China[J]. JOURNAL OF NEUROVIROLOGY,2008,14(6):536-549.
APA Heaton, Robert K..,Cysique, Lucette A..,Jin, Hua.,Shi, Chuan.,Yu, Xin.,...&San Diego HIV Neurobehav Res Ctr G.(2008).Neurobehavioral effects of human immunodeficiency virus infection among former plasma donors in rural China.JOURNAL OF NEUROVIROLOGY,14(6),536-549.
MLA Heaton, Robert K.,et al."Neurobehavioral effects of human immunodeficiency virus infection among former plasma donors in rural China".JOURNAL OF NEUROVIROLOGY 14.6(2008):536-549.
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