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学科主题: 精神卫生
题名:
Neurobehavioral effects of human immunodeficiency virus infection among former plasma donors in rural China
作者: Heaton, Robert K.1; Cysique, Lucette A.1; Jin, Hua1,2; Shi, Chuan3; Yu, Xin3; Letendre, Scott1; Franklin, Donald R., Jr.1; Ake, Christopher1; Vigil, Ofilio1; Atkinson, J. Hampton1; Marcotte, Thomas D.1; Grant, Igor1; Wu, Zunyou4; San Diego HIV Neurobehav Res Ctr G
关键词: HIV ; HCV ; neurocognitive disorders ; China
刊名: JOURNAL OF NEUROVIROLOGY
发表日期: 2008-12-01
DOI: 10.1080/13550280802378880
卷: 14, 期:6, 页:536-549
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences ; Virology
研究领域[WOS]: Neurosciences & Neurology ; Virology
关键词[WOS]: HEPATITIS-C VIRUS ; NERVOUS-SYSTEM INVOLVEMENT ; WORLD-HEALTH-ORGANIZATION ; SUB-SAHARAN AFRICA ; HIV-INFECTION ; NEUROPSYCHOLOGICAL IMPAIRMENT ; ANTIRETROVIRAL THERAPY ; NEUROCOGNITIVE IMPAIRMENT ; NEUROPSYCHIATRIC AIDS ; COGNITIVE IMPAIRMENT
英文摘要:

The human immunodeficiency virus (HIV) epidemic in China has expanded rapidly in recent years, but little is known about the prevalence and features of HIV-associated neurocognitive disorders (HANDs) in this part of the world. We administered a comprehensive Western neuropsychological (NP) test battery to 203 HIV+ and 198 HIV - former plasma donors in the rural area of Anhui province. They found that 26% of the HIV - samples, and 46% of the HIV+ samples, were infected with hepatitis C virus (HCV), which can also have central nervous system (CNS) effects. To classify NP impairment, we developed demographically corrected test norms based upon individuals free of both infections (N = 141). Using a global summary score, NP impairment was found in 34.2% of the HIV-monoinfected group and 39.7% of the coinfected group, as compared to 12.7% of the uninfected controls (P < .001). HIV+ participants with acquired immunodeficiency syndrome (AIDS) were more likely to be impaired (43%) than non-AIDS individuals (29%; P < .05). Lastly, when all infection groups were combined, participants with NP impairment reported more cognitive complaints (P < .01) and increased dependence in everyday functioning (P = .01). In sum, NP impairment in this large rural Chinese sample was associated with both HIV and HCV infections, and the impairment′s prevalence, severity, and pattern were

语种: 英语
所属项目编号: 5 R01 MH073433-04 ; MH 62512
项目资助者: NIMH
WOS记录号: WOS:000262851400009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64497
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Natl Ctr AIDS STD Control & Prevent NCAIDS, Beijing, Peoples R China
2.VA San Diego Hlth Care Syst, San Diego, CA USA
3.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
4.Univ Calif San Diego, Dept Psychiat, HIV Neurobehav Res Ctr HNRC, La Jolla, CA 92093 USA

Recommended Citation:
Heaton, Robert K.,Cysique, Lucette A.,Jin, Hua,et al. Neurobehavioral effects of human immunodeficiency virus infection among former plasma donors in rural China[J]. JOURNAL OF NEUROVIROLOGY,2008,14(6):536-549.
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