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Anti-histones antibodies in systemic lupus erythematosus: Prevalence and frequency in neuropsychiatric lupus
Sun, Xiao-Yun; Shi, Jinxia; Han, Lei; Su, Yin; Li, Zhan-Guo
关键词autoantibody histones systemic lupus erythematosus neuropsychiatric lupus
刊名JOURNAL OF CLINICAL LABORATORY ANALYSIS
2008
DOI10.1002/jcla.20248
22期:4页:271-277
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medical Laboratory Technology
研究领域[WOS]Medical Laboratory Technology
关键词[WOS]DISEASE-ACTIVITY INDEX ; ANTIHISTONE ANTIBODIES ; RHEUMATOID-ARTHRITIS ; CLINICAL-FEATURES ; REVISED CRITERIA ; DNA ; SPECIFICITY ; NUCLEOSOME ; SERUM ; REACTIVITY
英文摘要

To investigate the specificity, sensitivity, and concomitant presence of antibodies against histones (H), histone H1 (H1), and histone H3 (H3) in patients with systemic lupus erythematosus (SLE) and analyze their association with SLE. Serum IgG anti-histones antibodies were detected by enzyme-linked immunosorbent assay in 144 SLE patients consisting of 24 neuropsychiatric lupus (NPSLE), 65 lupus nephritis (LN), and 55 SLE, 100 other rheumatic diseases patients, as well as 40 healthy controls. Clinical and biological parameters of the patients were also evaluated. Anti-H, anti-H1, and anti-H3 antibodies yielded a sensitivity of approximately 33% and a specificity of more than 93% for SLE, which was comparable to that found for anti-double-stranded DNA (anti-dsDNa) antibodies. More significantly, anti-histone antibody is found in approximately 50% of patients with NPSLE compared with LN. Moreover, the titers of anti-histones antibodies of NPSLE patients were significantly higher than that of patients with SLE and LN. The sequential analysis revealed a close correlation of anti-H and anti-H1 antibodies with SLE disease activity. There was an approximate 30% positive rate of anti-histones antibodies in 144 SLE patients lacking anti-nucleosome, anti-mDNA, anti-Sm, and anti-dsDNA antibodies. Antibodies to histones H1 and H3 are markers with high specificity of 93.6-96.4% for SLE. The anti-histone antibody markers are prevalent in approximately 50% of NPSLE. Furthermore, there was a strong correlation with SLE disease activity index and levels of antibodies to histones and H1.

语种英语
WOS记录号WOS:000257900400008
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64498
专题北京大学第二临床医学院
北京大学第二临床医学院_风湿免疫科
作者单位Peking Univ, Sch Med, Dept Rheumatol & Immunol, Peoples Hosp, Beijing 100044, Peoples R China
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GB/T 7714
Sun, Xiao-Yun,Shi, Jinxia,Han, Lei,et al. Anti-histones antibodies in systemic lupus erythematosus: Prevalence and frequency in neuropsychiatric lupus[J]. JOURNAL OF CLINICAL LABORATORY ANALYSIS,2008,22(4):271-277.
APA Sun, Xiao-Yun,Shi, Jinxia,Han, Lei,Su, Yin,&Li, Zhan-Guo.(2008).Anti-histones antibodies in systemic lupus erythematosus: Prevalence and frequency in neuropsychiatric lupus.JOURNAL OF CLINICAL LABORATORY ANALYSIS,22(4),271-277.
MLA Sun, Xiao-Yun,et al."Anti-histones antibodies in systemic lupus erythematosus: Prevalence and frequency in neuropsychiatric lupus".JOURNAL OF CLINICAL LABORATORY ANALYSIS 22.4(2008):271-277.
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