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Odontoblast beta-catenin signaling regulates fenestration of mouse Hertwig′s epithelial root sheath
Zhang Ran1,2; Teng Yan2; Zhu Liang2; Lin JingTing2; Yang Xiao2; Yang Guan2; Li TieJun1
关键词Hertwig&prime s epithelial root sheath beta-catenin signaling BMP signaling mesenchyme-epithelium induction
刊名SCIENCE CHINA-LIFE SCIENCES
2015-09-01
DOI10.1007/s11427-015-4882-8
58期:9页:876-881
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biology
资助者State Key Program of the National Natural Science Foundation of China ; National Basic Research Program of China ; National Natural Science Foundation of China ; State Key Program of the National Natural Science Foundation of China ; National Basic Research Program of China ; National Natural Science Foundation of China
研究领域[WOS]Life Sciences & Biomedicine - Other Topics
关键词[WOS]DIFFERENTIATION ; MOLAR ; RAT
英文摘要

The interaction between Hertwig′s epithelial root sheath (HERS) and the adjacent mesenchyme is vitally important in mouse tooth root development. We previously generated odontoblast-specific Ctnnb1 (encoding beta-catenin) deletion mice, and demonstrated that odontoblast beta-catenin signaling regulates odontoblast proliferation and differentiation. However, the role of odontoblast beta-catenin signaling in regulation of HERS behavior has not been fully investigated. Here, using the same odontoblast- specific Ctnnb1 deletion mice, we found that ablation of beta-catenin signaling in odontoblasts led to aberrant HERS formation. Mechanistically, odontoblast-specific Ctnnb1 deletion resulted in elevated bone morphogenetic protein 7 (Bmp7) expression and reduced expression of noggin and follistatin, both of which encode extracellular inhibitors of BMPs. Furthermore, the levels of phosphorylated Smad1/5/8 were increased in HERS cells. In vitro tissue culture confirmed that BMP7 treatment disrupted the HERS structure. Taken together, we demonstrated that odontoblast beta-catenin signaling may act through regulation of BMP signaling to maintain the integrity of HERS cells.

语种英语
所属项目编号81030018 ; 2012CB966904 ; 30900863 ; 81241062
资助者State Key Program of the National Natural Science Foundation of China ; National Basic Research Program of China ; National Natural Science Foundation of China ; State Key Program of the National Natural Science Foundation of China ; National Basic Research Program of China ; National Natural Science Foundation of China
WOS记录号WOS:000362337500006
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64499
专题北京大学口腔医学院_口腔病理科
作者单位1.Peking Univ, Dept Oral Pathol, Sch & Hosp Stomatol, Beijing 100081, Peoples R China
2.Inst Biotechnol, State Key Lab Prote, Genet Lab Dev & Dis, Beijing 100071, Peoples R China
推荐引用方式
GB/T 7714
Zhang Ran,Teng Yan,Zhu Liang,et al. Odontoblast beta-catenin signaling regulates fenestration of mouse Hertwig′s epithelial root sheath[J]. SCIENCE CHINA-LIFE SCIENCES,2015,58(9):876-881.
APA Zhang Ran.,Teng Yan.,Zhu Liang.,Lin JingTing.,Yang Xiao.,...&Li TieJun.(2015).Odontoblast beta-catenin signaling regulates fenestration of mouse Hertwig′s epithelial root sheath.SCIENCE CHINA-LIFE SCIENCES,58(9),876-881.
MLA Zhang Ran,et al."Odontoblast beta-catenin signaling regulates fenestration of mouse Hertwig′s epithelial root sheath".SCIENCE CHINA-LIFE SCIENCES 58.9(2015):876-881.
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