IR@PKUHSC  > 北京大学第二临床医学院
学科主题临床医学
Beta-arrestin 2 modulates resveratrol-induced apoptosis and regulation of Akt/GSK3 beta pathways
Sun, Xiuli1,2; Zhang, Yi2; Wang, Jianliu1; Wei, Lihui1; Li, Hui2; Hanley, Gregory3; Zhao, Miaoqing2; Li, Yi2; Yin, Deling2
关键词Endometrial cancer beta-Arrestin 2 Resveratrol Apoptosis Akt GSK3 beta
刊名BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
2010-09-01
DOI10.1016/j.bbagen.2010.04.015
1800期:9页:912-918
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]GLYCOGEN-SYNTHASE KINASE-3 ; BREAST-CANCER CELLS ; RECEPTOR ; PROTEIN ; ACTIVATION ; EXPRESSION ; GROWTH ; MCF-7 ; GSK3
英文摘要

Background: Resveratrol is emerging as a novel anticancer agent. However, the mechanism(s) by which resveratrol exerts its effects on endometrial cancer (EC) are unknown. We previously reported that beta-arrestin 2 plays a critical role in cell apoptosis. The role of beta-arrestin 2 in resveratrol modulation of endometrial cancer cell apoptosis remains to be established. Scope of Review: EC cells HEC1B and Ishikawa were transfected with either beta-arrestin 2 RNA interfering (RNAi) plasmid or beta-arrestin 2 full-length plasmid and control vector. The cells were then exposed to differing concentrations of resveratrol. Apoptotic cells were detected by TUNEL assay. Expression of total and phosphorylated Akt (p-Akt), total and phosphorylated glycogen synthase kinase 3 beta (p-GSK3 beta), and caspase-3 were determined by Western blot analysis. Our data demonstrate that inhibition of beta-arrestin 2 increases the number of apoptotic cells and caspase-3 activation. Additionally beta-arrestin 2 exerted an additive effect on resveratrol-reduced levels of p-Akt and p-GSK3 beta. Overexpression of beta-arrestin 2 decreased the percentage of apoptosis and caspase-3 activation and attenuated resveratrol-reduced levels of p-Akt and p-GSK3 beta. Taken together, our studies demonstrate for the first time that beta-arrestin 2 mediated signaling plays a critical role in resveratrol-induced apoptosis in EC cells.

Major Conclusions: Resveratrol primes EC cells to undergo apoptosis by modulating beta-arrestin 2 mediated Akt/GSK3 beta signaling pathways.

General significance: These inspiring findings would provide a new molecular basis for further understanding of cell apoptotic mechanisms mediated by beta-arrestin 2 and may provide insights into a potential clinical relevance in EC. (C) 2010 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000281182800003
项目编号DA020120-03A1 ; 30571937 ; 30571938
资助机构National Institutes of Health (NIH) ; National Natural Science Foundation of China
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64500
专题北京大学第二临床医学院
作者单位1.Peking Univ, Peoples Hosp, Dept Obstet & Gynecol, Beijing 100871, Peoples R China
2.E Tennessee State Univ, Coll Med, Dept Internal Med, Johnson City, TN 37614 USA
3.E Tennessee State Univ, Dept Lab Anim Resources, James H Quillen Coll Med, Johnson City, TN 37614 USA
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GB/T 7714
Sun, Xiuli,Zhang, Yi,Wang, Jianliu,et al. Beta-arrestin 2 modulates resveratrol-induced apoptosis and regulation of Akt/GSK3 beta pathways[J]. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS,2010,1800(9):912-918.
APA Sun, Xiuli.,Zhang, Yi.,Wang, Jianliu.,Wei, Lihui.,Li, Hui.,...&Yin, Deling.(2010).Beta-arrestin 2 modulates resveratrol-induced apoptosis and regulation of Akt/GSK3 beta pathways.BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS,1800(9),912-918.
MLA Sun, Xiuli,et al."Beta-arrestin 2 modulates resveratrol-induced apoptosis and regulation of Akt/GSK3 beta pathways".BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS 1800.9(2010):912-918.
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