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学科主题临床医学
Early retinal vascular abnormalities in African-American cocaine users
Leung, Ivan Y. -F.1; Lai, Shenghan2; Ren, Shiquan2; Kempen, John4,5,6; Klein, Ronald7; Tso, Mark O. M.1,8; Lai, Hong C.1,3
刊名AMERICAN JOURNAL OF OPHTHALMOLOGY
2008-10-01
DOI10.1016/j.ajo.2008.05.037
146期:4页:612-619
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Ophthalmology
研究领域[WOS]Ophthalmology
关键词[WOS]LONGITUDINAL DATA-ANALYSIS ; ATHEROSCLEROSIS RISK ; VESSEL DIAMETERS ; BLOOD-PRESSURE ; MICROVASCULAR ABNORMALITIES ; DIABETIC-RETINOPATHY ; ARTERIOLAR DIAMETER ; OLDER POPULATION ; HEALTHY-ADULTS ; COMMUNITIES
英文摘要

PURPOSE: To investigate whether cocaine use is associated with early retinal vascular abnormalities.

DESIGN: Population-based cross-sectional study.

METHODS: SETTINGS: Inner-city neighborhoods in Baltimore, Maryland. STUDY POPULATION: Sixty-eight participants were recruited from an ongoing observational study, investigating cardiovascular complications of human immunodeficiency virus (HIV) infection and cocaine use in African Americans aged between 25 and 54 years. Those with hypertension and known cardiovascular/cerebrovascular diseases were excluded. OBSERVATION PROCEDURES: Ophthalmoscopic examinations and fundus photography of the retinas of these subjects were performed after pupillary dilation. The largest angle of arterial bifurcation (LAAB), central retinal artery equivalent (CRAE), and central retinal vein equivalent (CRVE) were measured by single-masked fundus image examiners. MAIN OUTCOME MEASURES: LAAB, CRAE, and CRVE.

RESULTS: Among the 68 study subjects, 52 (76.5%) were chronic cocaine users and 16 (23.5%) were non-cocaine users. Univariate and multivariate analyses indicated that the LAAB was associated with age and duration of cocaine use of more than 10 years. The LAAB was also inversely associated with very low, density lipoproteins levels. Multivariate analysis indicated a positive association between CRVE and cocaine use. CRAE was also associated with intravenous injection. We confirmed that CRAE was inversely associated with age. HIV infection was not found to be associated with any retinal vascular parameters.

CONCLUSIONS: Cocaine use is associated with increased retinal arterial branching angle and venular caliber. The retinal vascular changes provided the first evidence that cocaine use has an effect on the retinal vascular system.

语种英语
WOS记录号WOS:000259742200021
项目编号R01DA12777 ; R01DA15020
资助机构NATIONAL INSTITUTE ON DRUG ABUSE (NIDA) ; NATIONAL INSTITUTES OF HEALTH (NIH) ; Paul and Evanina Mackall Foundation
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64502
专题北京大学第三临床医学院_眼科
作者单位1.Johns Hopkins Univ, Wilmer Eye Inst, Baltimore, MD 21218 USA
2.Johns Hopkins Univ, Dept Pathol, Baltimore, MD USA
3.Johns Hopkins Univ, Dept Radiol, Baltimore, MD USA
4.Univ Penn, Dept Ophthalmol, Philadelphia, PA 19104 USA
5.Univ Penn, Dept Biostat & Epidemiol, Philadelphia, PA 19104 USA
6.Univ Penn, Ctr Clin Epidemiol & Biostat, Philadelphia, PA 19104 USA
7.Univ Wisconsin, Dept Ophthalmol & Visual Sci, Madison, WI USA
8.Peking Univ, Teaching Hosp 3, Ctr Eye, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Leung, Ivan Y. -F.,Lai, Shenghan,Ren, Shiquan,et al. Early retinal vascular abnormalities in African-American cocaine users[J]. AMERICAN JOURNAL OF OPHTHALMOLOGY,2008,146(4):612-619.
APA Leung, Ivan Y. -F..,Lai, Shenghan.,Ren, Shiquan.,Kempen, John.,Klein, Ronald.,...&Lai, Hong C..(2008).Early retinal vascular abnormalities in African-American cocaine users.AMERICAN JOURNAL OF OPHTHALMOLOGY,146(4),612-619.
MLA Leung, Ivan Y. -F.,et al."Early retinal vascular abnormalities in African-American cocaine users".AMERICAN JOURNAL OF OPHTHALMOLOGY 146.4(2008):612-619.
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