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学科主题: 临床医学
题名:
Early retinal vascular abnormalities in African-American cocaine users
作者: Leung, Ivan Y. -F.1; Lai, Shenghan2; Ren, Shiquan2; Kempen, John4,5,6; Klein, Ronald7; Tso, Mark O. M.1,8; Lai, Hong C.1,3
刊名: AMERICAN JOURNAL OF OPHTHALMOLOGY
发表日期: 2008-10-01
DOI: 10.1016/j.ajo.2008.05.037
卷: 146, 期:4, 页:612-619
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Ophthalmology
研究领域[WOS]: Ophthalmology
关键词[WOS]: LONGITUDINAL DATA-ANALYSIS ; ATHEROSCLEROSIS RISK ; VESSEL DIAMETERS ; BLOOD-PRESSURE ; MICROVASCULAR ABNORMALITIES ; DIABETIC-RETINOPATHY ; ARTERIOLAR DIAMETER ; OLDER POPULATION ; HEALTHY-ADULTS ; COMMUNITIES
英文摘要:

PURPOSE: To investigate whether cocaine use is associated with early retinal vascular abnormalities.

DESIGN: Population-based cross-sectional study.

METHODS: SETTINGS: Inner-city neighborhoods in Baltimore, Maryland. STUDY POPULATION: Sixty-eight participants were recruited from an ongoing observational study, investigating cardiovascular complications of human immunodeficiency virus (HIV) infection and cocaine use in African Americans aged between 25 and 54 years. Those with hypertension and known cardiovascular/cerebrovascular diseases were excluded. OBSERVATION PROCEDURES: Ophthalmoscopic examinations and fundus photography of the retinas of these subjects were performed after pupillary dilation. The largest angle of arterial bifurcation (LAAB), central retinal artery equivalent (CRAE), and central retinal vein equivalent (CRVE) were measured by single-masked fundus image examiners. MAIN OUTCOME MEASURES: LAAB, CRAE, and CRVE.

RESULTS: Among the 68 study subjects, 52 (76.5%) were chronic cocaine users and 16 (23.5%) were non-cocaine users. Univariate and multivariate analyses indicated that the LAAB was associated with age and duration of cocaine use of more than 10 years. The LAAB was also inversely associated with very low, density lipoproteins levels. Multivariate analysis indicated a positive association between CRVE and cocaine use. CRAE was also associated with intravenous injection. We confirmed that CRAE was inversely associated with age. HIV infection was not found to be associated with any retinal vascular parameters.

CONCLUSIONS: Cocaine use is associated with increased retinal arterial branching angle and venular caliber. The retinal vascular changes provided the first evidence that cocaine use has an effect on the retinal vascular system.

语种: 英语
所属项目编号: R01DA12777 ; R01DA15020
项目资助者: NATIONAL INSTITUTE ON DRUG ABUSE (NIDA) ; NATIONAL INSTITUTES OF HEALTH (NIH) ; Paul and Evanina Mackall Foundation
WOS记录号: WOS:000259742200021
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64502
Appears in Collections:北京大学第三临床医学院_眼科_期刊论文

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作者单位: 1.Johns Hopkins Univ, Wilmer Eye Inst, Baltimore, MD 21218 USA
2.Johns Hopkins Univ, Dept Pathol, Baltimore, MD USA
3.Johns Hopkins Univ, Dept Radiol, Baltimore, MD USA
4.Univ Penn, Dept Ophthalmol, Philadelphia, PA 19104 USA
5.Univ Penn, Dept Biostat & Epidemiol, Philadelphia, PA 19104 USA
6.Univ Penn, Ctr Clin Epidemiol & Biostat, Philadelphia, PA 19104 USA
7.Univ Wisconsin, Dept Ophthalmol & Visual Sci, Madison, WI USA
8.Peking Univ, Teaching Hosp 3, Ctr Eye, Beijing 100871, Peoples R China

Recommended Citation:
Leung, Ivan Y. -F.,Lai, Shenghan,Ren, Shiquan,et al. Early retinal vascular abnormalities in African-American cocaine users[J]. AMERICAN JOURNAL OF OPHTHALMOLOGY,2008,146(4):612-619.
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