IR@PKUHSC  > 北京大学基础医学院  > 神经生物学系
学科主题基础医学
CCKB receptor antagonist L365,260 potentiates the efficacy to and reverses chronic tolerance to electroacupuncture-induced analgesia in mice
Huang, Cheng; Hu, Zhi-Pin; Jiang, Shao-Zu; Li, Han-Ting; Han, Ji-Sheng; Wan, You
关键词Cholecystokinin Octapeptide Cck-8 Cckb Receptor Acupuncture L365 Analgesia 260 Tolerance
刊名BRAIN RESEARCH BULLETIN
2007-03-15
DOI10.1016/j.brainresbull.2006.11.008
71期:5页:447-451
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]CHOLECYSTOKININ-OCTAPEPTIDE CCK-8 ; RAT SPINAL-CORD ; ELECTRICAL-STIMULATION ; INCREASED RELEASE ; OPIOID ANALGESIA ; OPIATE ANALGESIA ; BACK-PAIN ; MORPHINE ; ACUPUNCTURE ; INVOLVEMENT
英文摘要

Cholecystokinin octapeptide (CCK-8) is a physiological antagonist of endogenous opioids in the central nervous system (CNS). Our previous work has shown that CCK-8 plays an important role in the development of tolerance to morphine analgesia and electroacupuncture (EA) analgesia in the rat. The present studies were designed to examine whether the CCKB receptor is involved in the modulation of EA analgesia and the development of EA tolerance in mice. The latency to flick the tail in the radiant heat was used as index to assess the efficacy of EA analgesia. Subcutaneous (s.c.) injection of the CCKB receptor antagonist L365,260 produced a dose-dependent (0.125-2.0 mg/kg) potentiation of the analgesia induced by 100 Hz EA, with a maximal effect occurred at 0.5 mg/kg. In addition, L365,260 (0.5 mg/kg) significantly reversed chronic tolerance to 100 Hz EA in mice. These results suggest that the CCKB receptor might play a role in the ionic inhibition of 100 Hz EA-induced analgesia and in the mediation of chronic tolerance to 100 Hz EA in mice. The results opened a way for further investigation of the function of CCK-8 in pain modulation using inbred strains of mice. (c) 2006 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000244411500002
Citation statistics
Cited Times:24[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64505
Collection北京大学基础医学院_神经生物学系
作者单位1.Peking Univ, Neurosci Res Inst, Key Lab Neurosci, Beijing 100083, Peoples R China
2.Peking Univ, Dept Neurobiol, Key Lab Neurosci, Beijing 100083, Peoples R China
3.Gannan Med Univ, Dept Physiol, Ganzhou 341000, Peoples R China
Recommended Citation
GB/T 7714
Huang, Cheng,Hu, Zhi-Pin,Jiang, Shao-Zu,et al. CCKB receptor antagonist L365,260 potentiates the efficacy to and reverses chronic tolerance to electroacupuncture-induced analgesia in mice[J]. BRAIN RESEARCH BULLETIN,2007,71(5):447-451.
APA Huang, Cheng,Hu, Zhi-Pin,Jiang, Shao-Zu,Li, Han-Ting,Han, Ji-Sheng,&Wan, You.(2007).CCKB receptor antagonist L365,260 potentiates the efficacy to and reverses chronic tolerance to electroacupuncture-induced analgesia in mice.BRAIN RESEARCH BULLETIN,71(5),447-451.
MLA Huang, Cheng,et al."CCKB receptor antagonist L365,260 potentiates the efficacy to and reverses chronic tolerance to electroacupuncture-induced analgesia in mice".BRAIN RESEARCH BULLETIN 71.5(2007):447-451.
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