北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 基础医学院  > 神经生物学系  > 期刊论文
学科主题: 基础医学
题名:
CCKB receptor antagonist L365,260 potentiates the efficacy to and reverses chronic tolerance to electroacupuncture-induced analgesia in mice
作者: Huang, Cheng; Hu, Zhi-Pin; Jiang, Shao-Zu; Li, Han-Ting; Han, Ji-Sheng; Wan, You
关键词: cholecystokinin octapeptide ; CCK-8 ; CCKB receptor ; L365,260 ; acupuncture ; analgesia ; tolerance
刊名: BRAIN RESEARCH BULLETIN
发表日期: 2007-03-15
DOI: 10.1016/j.brainresbull.2006.11.008
卷: 71, 期:5, 页:447-451
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: CHOLECYSTOKININ-OCTAPEPTIDE CCK-8 ; RAT SPINAL-CORD ; ELECTRICAL-STIMULATION ; INCREASED RELEASE ; OPIOID ANALGESIA ; OPIATE ANALGESIA ; BACK-PAIN ; MORPHINE ; ACUPUNCTURE ; INVOLVEMENT
英文摘要:

Cholecystokinin octapeptide (CCK-8) is a physiological antagonist of endogenous opioids in the central nervous system (CNS). Our previous work has shown that CCK-8 plays an important role in the development of tolerance to morphine analgesia and electroacupuncture (EA) analgesia in the rat. The present studies were designed to examine whether the CCKB receptor is involved in the modulation of EA analgesia and the development of EA tolerance in mice. The latency to flick the tail in the radiant heat was used as index to assess the efficacy of EA analgesia. Subcutaneous (s.c.) injection of the CCKB receptor antagonist L365,260 produced a dose-dependent (0.125-2.0 mg/kg) potentiation of the analgesia induced by 100 Hz EA, with a maximal effect occurred at 0.5 mg/kg. In addition, L365,260 (0.5 mg/kg) significantly reversed chronic tolerance to 100 Hz EA in mice. These results suggest that the CCKB receptor might play a role in the ionic inhibition of 100 Hz EA-induced analgesia and in the mediation of chronic tolerance to 100 Hz EA in mice. The results opened a way for further investigation of the function of CCK-8 in pain modulation using inbred strains of mice. (c) 2006 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000244411500002
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64505
Appears in Collections:基础医学院_神经生物学系_期刊论文

Files in This Item:
File Name/ File Size Content Type Version Access License
CCKB receptor antagonist L365,260 potentiates the efficacy to and reverses chronic tolerance to electroacupuncture-induced analgesia in mice.pdf(243KB)期刊论文出版稿限制开放 联系获取全文

作者单位: 1.Peking Univ, Neurosci Res Inst, Key Lab Neurosci, Beijing 100083, Peoples R China
2.Peking Univ, Dept Neurobiol, Key Lab Neurosci, Beijing 100083, Peoples R China
3.Gannan Med Univ, Dept Physiol, Ganzhou 341000, Peoples R China

Recommended Citation:
Huang, Cheng,Hu, Zhi-Pin,Jiang, Shao-Zu,et al. CCKB receptor antagonist L365,260 potentiates the efficacy to and reverses chronic tolerance to electroacupuncture-induced analgesia in mice[J]. BRAIN RESEARCH BULLETIN,2007,71(5):447-451.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Huang, Cheng]'s Articles
[Hu, Zhi-Pin]'s Articles
[Jiang, Shao-Zu]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Huang, Cheng]‘s Articles
[Hu, Zhi-Pin]‘s Articles
[Jiang, Shao-Zu]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace