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学科主题: 药物依赖
题名:
Stress within a Restricted Time Window Selectively Affects the Persistence of Long-Term Memory
作者: Yang, Chang1,2; Liu, Jian-Feng3; Chai, Bai-Sheng1,2; Fang, Qin1,2; Chai, Ning4,5; Zhao, Li-Yan3; Xue, Yan-Xue3; Luo, Yi-Xiao3; Jian, Min3; Han, Ying3; Shi, Hai-Shui6; Lu, Lin3; Wu, Ping3; Wang, Ji-Shi1,2
刊名: PLOS ONE
发表日期: 2013-03-27
DOI: 10.1371/journal.pone.0059075
卷: 8, 期:3
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: INDUCED CORTISOL ELEVATIONS ; MEDIAL PREFRONTAL CORTEX ; BASOLATERAL AMYGDALA ; SPATIAL MEMORY ; FEAR MEMORIES ; GLUCOCORTICOID-RECEPTORS ; PSYCHOSOCIAL STRESS ; DECLARATIVE MEMORY ; PROTEIN-SYNTHESIS ; LEARNING STRESS
英文摘要:

The effects of stress on emotional memory are distinct and depend on the stages of memory. Memory undergoes consolidation and reconsolidation after acquisition and retrieval, respectively. Stress facilitates the consolidation but disrupts the reconsolidation of emotional memory. Previous research on the effects of stress on memory have focused on long-term memory (LTM) formation (tested 24 h later), but the effects of stress on the persistence of LTM (tested at least week later) are unclear. Recent findings indicated that the persistence of LTM requires late-phase protein synthesis in the 1 dorsal hippocampus. The present study investigated the effect of stress (i.e., cold water stress) during the late phase after the acquisition and retrieval of contextual fear memory in rats. We found that stress and corticosterone administration during the late phase (12 h) after acquisition, referred to as late consolidation, selectively enhanced the persistence of LTM, whereas stress during the late phase (12 h) after retrieval, referred to as late reconsolidation, selectively disrupted the restabilized persistence of LTM. Moreover, the effects of stress on the persistence of LTM were blocked by the corticosterone synthesis inhibitor metyrapone, which was administered before stress, suggesting that the glucocorticoid system is involved in the effects of stress on the persistence of LTM. We conclude that stress within a restricted time window after acquisition or retrieval selectively affects the persistence of LTM and depends on the glucocorticoid system.

语种: 英语
所属项目编号: 81201032 ; 91132716 ; 31070958
项目资助者: Natural Science Foundation of China
WOS记录号: WOS:000317480700013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64506
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: 1.Affiliated Hosp, Guiyang, Peoples R China
2.Guiyang Med Univ, Sch Pharm, Guiyang, Peoples R China
3.Peking Univ, Natl Inst Drug Dependence, Beijing 100871, Peoples R China
4.Hebei Med Univ, Inst Mental Hlth, Shijiazhuang, Peoples R China
5.Hebei Med Univ, Hebei Brain Ageing & Cognit Neurosci Lab, Shijiazhuang, Peoples R China
6.Hebei Med Univ, Basic Med Coll, Dept Biochem & Mol Biol, Shijiazhuang, Peoples R China

Recommended Citation:
Yang, Chang,Liu, Jian-Feng,Chai, Bai-Sheng,et al. Stress within a Restricted Time Window Selectively Affects the Persistence of Long-Term Memory[J]. PLOS ONE,2013,8(3).
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