IR@PKUHSC  > 北京大学第三临床医学院
学科主题临床医学
Aspergillus flavus myositis in a patient after liver transplantation
Li, Dong Ming1,3,4; Xiu, Dian Rong2; Li, Ruo Yu3; Samson, R. A.4; de Hoog, G. S.4; Wang, Duan Li3
关键词aspergillosis Aspergillus flavus liver transplantation myositis
刊名CLINICAL TRANSPLANTATION
2008-07-01
DOI10.1111/j.1399-0012.2008.00801.x
22期:4页:508-511
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Surgery ; Transplantation
研究领域[WOS]Surgery ; Transplantation
关键词[WOS]IN-VITRO ACTIVITIES ; INVASIVE ASPERGILLOSIS ; ANTIFUNGAL AGENTS ; AMPHOTERICIN-B ; FUMIGATUS ; SUSCEPTIBILITY ; INFECTIONS ; RECIPIENTS ; AIDS
英文摘要

We describe the first case of Aspergillus myositis caused by Aspergillus flavus in a liver transplant patient. The patient was a 43-year-old man who underwent liver transplantation because of end-stage hepatic cirrhosis. He experienced pain in his left calf two months after the operation. Nodules with weakness, swelling, and flaring were found in the calf two wk later. Color ultrasonic examination showed uneven resonance in the left gastrocnemius. Needle aspiration and biopsy of the muscle revealed septate hyphae consistent with Aspergillus species and focal necrosis of the muscle cells with inflammatory cell infiltration. A culture subsequently yielded A. flavus, confirming histopathologic diagnosis. Sequencing of the internal transcribed spacer region confirmed the morphologic identification. The patient was first given itraconazole 0.2 g twice daily for one wk and was then switched to terbinafine 0.25 g once a day. A three-month regimen of terbinafine therapy cured the infection, though the cultured fungus showed resistance to a number of antifungal agents. Aspergillus, a genus of ubiquitous molds, may cause invasive and even fatal disease in immunosuppressed patients.

语种英语
WOS记录号WOS:000257778600016
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64512
专题北京大学第三临床医学院
作者单位1.Peking Univ, Hosp 3, Dept Surg, Beijing 100083, Peoples R China
2.Peking Univ, Res Ctr Med Mycol, Beijing 100083, Peoples R China
3.Cent Bur Schimmelcultures, Utrecht, Netherlands
4.Peking Univ, Hosp 3, Mycol Lab Dermatol, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Li, Dong Ming,Xiu, Dian Rong,Li, Ruo Yu,et al. Aspergillus flavus myositis in a patient after liver transplantation[J]. CLINICAL TRANSPLANTATION,2008,22(4):508-511.
APA Li, Dong Ming,Xiu, Dian Rong,Li, Ruo Yu,Samson, R. A.,de Hoog, G. S.,&Wang, Duan Li.(2008).Aspergillus flavus myositis in a patient after liver transplantation.CLINICAL TRANSPLANTATION,22(4),508-511.
MLA Li, Dong Ming,et al."Aspergillus flavus myositis in a patient after liver transplantation".CLINICAL TRANSPLANTATION 22.4(2008):508-511.
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