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学科主题基础医学
The Protective Effect of Cerebralcare Granule (R) on Brain Edema, Cerebral Microcirculatory Disturbance, and Neuron Injury in a Focal Cerebral Ischemia Rat Model
Wang, Fang2; Hu, Qin3; Chen, Chun-Hua3; Xu, Xiang-Shun2; Zhou, Chang-Man3; Zhao, Ya-Fang2; Hu, Bai-He2; Chang, Xin2; Huang, Ping2; Yang, Lei3; Liu, Yu-Ying2; Wang, Chuan-She2; Fan, Jing-Yu2; Zhang, Ke4; Li, Guo-Yu4; Wang, Jing-Hui4; Han, Jing-Yan1,2
关键词ischemia and reperfusion middle cerebral artery occlusion neuron injury cerebral microcirculatory disturbance brain edema
刊名MICROCIRCULATION
2012-04-01
DOI10.1111/j.1549-8719.2011.00155.x
19期:3页:260-272
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology ; Peripheral Vascular Disease
资助者Ministry of Science and Technology of the People&prime ; s Republic of China ; Ministry of Science and Technology of the People&prime ; s Republic of China
研究领域[WOS]Hematology ; Cardiovascular System & Cardiology
关键词[WOS]ARTERY OCCLUSION ; BARRIER BREAKDOWN ; TETRAMETHYLPYRAZINE ; REPERFUSION ; STROKE ; DAMAGE ; EXPRESSION
英文摘要

Objective: The purpose of the present study was to explore the protective effects of CG on rat cerebral injury after focal cerebral I /R. Methods: Male SpragueDawley rats were subjected to right middle cerebral artery occlusion for 60 minutes followed by reperfusion for 60 minutes or 24 hours. CG (0.4 or 0.8 g/kg) was administrated 90 minutes before ischemia. Brian edema was evaluated by Evans blue dye extravasations and brain water content, leukocyte adhesion, and albumin leakage were determined with an upright fluorescence microscope, and neuron damage was assessed by 2,3,5-triphenyltetrazolium chloride staining, terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling, and immunohistochemistry of caspase-3, p53, p53 upregulated modulator of apoptosis. Results: Focal cerebral I/R elicited a prominent brain edema, an increase in leukocyte adhesion, and albumin leakage, as well as neuron damage. All the insults after focal cerebral I/R were significantly attenuated by pretreatment with CG. Conclusions: Pretreatment with CG significantly reduced focal cerebral I/R-induced brain edema, cerebral microcirculatory disturbance, and neuron damage, suggesting the potential of CG as a prophylactic strategy for patients in danger of stroke.

语种英语
所属项目编号2008ZX09401
资助者Ministry of Science and Technology of the People&prime ; s Republic of China ; Ministry of Science and Technology of the People&prime ; s Republic of China
WOS记录号WOS:000302074600008
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64515
专题基础医学院
作者单位1.Peking Univ, Dept Integrat Chinese & Western Med, Sch Basic Med Sci, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Tasly Microcirculat Res Ctr, Beijing 100191, Peoples R China
3.Peking Univ, Dept Anat, Sch Basic Med Sci, Beijing 100191, Peoples R China
4.Shihezi Univ, Sch Pharm, Xinjiang, Peoples R China
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GB/T 7714
Wang, Fang,Hu, Qin,Chen, Chun-Hua,et al. The Protective Effect of Cerebralcare Granule (R) on Brain Edema, Cerebral Microcirculatory Disturbance, and Neuron Injury in a Focal Cerebral Ischemia Rat Model[J]. MICROCIRCULATION,2012,19(3):260-272.
APA Wang, Fang.,Hu, Qin.,Chen, Chun-Hua.,Xu, Xiang-Shun.,Zhou, Chang-Man.,...&Han, Jing-Yan.(2012).The Protective Effect of Cerebralcare Granule (R) on Brain Edema, Cerebral Microcirculatory Disturbance, and Neuron Injury in a Focal Cerebral Ischemia Rat Model.MICROCIRCULATION,19(3),260-272.
MLA Wang, Fang,et al."The Protective Effect of Cerebralcare Granule (R) on Brain Edema, Cerebral Microcirculatory Disturbance, and Neuron Injury in a Focal Cerebral Ischemia Rat Model".MICROCIRCULATION 19.3(2012):260-272.
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