|Contrast-Enhanced Ultrasound in the Diagnosis of Gallbladder Diseases: A Multi-Center Experience|
|Liu, Lin-Na1; Xu, Hui-Xiong1,2; Lu, Ming-De2; Xie, Xiao-Yan2; Wang, Wen-Ping3; Hu, Bing4; Yan, Kun5; Ding, Hong3; Tang, Shao-Shan6; Qian, Lin-Xue7; Luo, Bao-Ming8; Wen, Yan-Ling9|
|WOS标题词||Science & Technology|
|研究领域[WOS]||Science & Technology - Other Topics|
|关键词[WOS]||DIFFERENTIAL-DIAGNOSIS ; ULTRASONOGRAPHY ; CHOLECYSTITIS ; SONOGRAPHY ; LESIONS ; CANCER|
Objective: To assess the usefulness of contrast-enhanced ultrasound (CEUS) in differentiating malignant from benign gallbladder (GB) diseases.
Methods: This study had institutional review board approval. 192 patients with GB diseases from 9 university hospitals were studied. After intravenous bonus injection of a phospholipid-stabilized shell microbubble contrast agent, lesions were scanned with low acoustic power CEUS. A multiple logistic regression analysis was performed to identify diagnostic clues from 17 independent variables that enabled differentiation between malignant and benign GB diseases. Receiver operating characteristic (ROC) curve analysis was performed.
Results: Among the 17 independent variables, multiple logistic regression analysis showed that the following 4 independent variables were associated with the benign nature of the GB diseases, including the patient age, intralesional blood vessel depicted on CEUS, contrast washout time, and wall intactness depicted on CEUS (all P<0.05). ROC analysis showed that the patient age, intralesional vessels on CEUS, and the intactness of the GB wall depicted on CEUS yielded an area under the ROC curve (Az) greater than 0.8 in each and Az for the combination of the 4 significant independent variables was 0.915 [95% confidence interval (CI): 0.857-0.974]. The corresponding Az, sensitivity, and specificity for the age were 0.805 (95% CI: 0.746-0.863), 92.2%%, and 59.6%; for the intralesional vessels on CEUS were 0.813 (95% CI: 0.751-0.875), 59.8%, and 98.0%; and for the GB wall intactness were 0.857 (95% CI: 0.786-0.928), 78.4%, and 92.9%. The cut-off values for benign GB diseases were patient age <53.5 yrs, dotted intralesional vessels on CEUS and intact GB wall on CEUS.
Conclusion: CEUS is valuable in differentiating malignant from benign GB diseases. Branched or linear intralesional vessels and destruction of GB wall on CEUS are the CEUS features highly suggestive of GB malignancy and the patient age >53.5 yrs is also a clue for GB malignancy.
|项目编号||2008-2-10 ; 20114003|
|资助机构||Chinese Ministry of Health ; Shanghai Health Bureau|
|作者单位||1.Tongji Univ, Peoples Hosp 10, Dept Med Ultrasound, Shanghai 200092, Peoples R China|
2.Sun Yat Sen Univ, Affiliated Hosp 1, Dept Med Ultrason, Guangzhou 510275, Guangdong, Peoples R China
3.Fudan Univ, Zhongshan Hosp, Dept Ultrasound, Shanghai 200433, Peoples R China
4.Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Ultrasound Med, Shanghai 200030, Peoples R China
5.Peking Univ, Sch Oncol, Beijing Canc Inst, Dept Ultrasound, Beijing 100871, Peoples R China
6.China Med Univ, Shengjing Hosp, Dept Ultrasound, Shenyang, Peoples R China
7.Capital Med Univ, Beijing Friendship Hosp, Dept Ultrasound, Beijing, Peoples R China
8.Sun Yat Sen Univ, Affiliated Hosp 2, Dept Ultrasound, Guangzhou 510275, Guangdong, Peoples R China
9.Sun Yat Sen Univ, Affiliated Hosp 6, Dept Ultrasound, Guangzhou 510275, Guangdong, Peoples R China
|Liu, Lin-Na,Xu, Hui-Xiong,Lu, Ming-De,et al. Contrast-Enhanced Ultrasound in the Diagnosis of Gallbladder Diseases: A Multi-Center Experience[J]. PLOS ONE,2012,7(10).|
|APA||Liu, Lin-Na.,Xu, Hui-Xiong.,Lu, Ming-De.,Xie, Xiao-Yan.,Wang, Wen-Ping.,...&Wen, Yan-Ling.(2012).Contrast-Enhanced Ultrasound in the Diagnosis of Gallbladder Diseases: A Multi-Center Experience.PLOS ONE,7(10).|
|MLA||Liu, Lin-Na,et al."Contrast-Enhanced Ultrasound in the Diagnosis of Gallbladder Diseases: A Multi-Center Experience".PLOS ONE 7.10(2012).|