IR@PKUHSC  > 北京大学临床肿瘤学院  > 超声科
学科主题临床医学
Contrast-Enhanced Ultrasound in the Diagnosis of Gallbladder Diseases: A Multi-Center Experience
Liu, Lin-Na1; Xu, Hui-Xiong1,2; Lu, Ming-De2; Xie, Xiao-Yan2; Wang, Wen-Ping3; Hu, Bing4; Yan, Kun5; Ding, Hong3; Tang, Shao-Shan6; Qian, Lin-Xue7; Luo, Bao-Ming8; Wen, Yan-Ling9
刊名PLOS ONE
2012-10-31
DOI10.1371/journal.pone.0048371
7期:10
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]DIFFERENTIAL-DIAGNOSIS ; ULTRASONOGRAPHY ; CHOLECYSTITIS ; SONOGRAPHY ; LESIONS ; CANCER
英文摘要

Objective: To assess the usefulness of contrast-enhanced ultrasound (CEUS) in differentiating malignant from benign gallbladder (GB) diseases.

Methods: This study had institutional review board approval. 192 patients with GB diseases from 9 university hospitals were studied. After intravenous bonus injection of a phospholipid-stabilized shell microbubble contrast agent, lesions were scanned with low acoustic power CEUS. A multiple logistic regression analysis was performed to identify diagnostic clues from 17 independent variables that enabled differentiation between malignant and benign GB diseases. Receiver operating characteristic (ROC) curve analysis was performed.

Results: Among the 17 independent variables, multiple logistic regression analysis showed that the following 4 independent variables were associated with the benign nature of the GB diseases, including the patient age, intralesional blood vessel depicted on CEUS, contrast washout time, and wall intactness depicted on CEUS (all P<0.05). ROC analysis showed that the patient age, intralesional vessels on CEUS, and the intactness of the GB wall depicted on CEUS yielded an area under the ROC curve (Az) greater than 0.8 in each and Az for the combination of the 4 significant independent variables was 0.915 [95% confidence interval (CI): 0.857-0.974]. The corresponding Az, sensitivity, and specificity for the age were 0.805 (95% CI: 0.746-0.863), 92.2%%, and 59.6%; for the intralesional vessels on CEUS were 0.813 (95% CI: 0.751-0.875), 59.8%, and 98.0%; and for the GB wall intactness were 0.857 (95% CI: 0.786-0.928), 78.4%, and 92.9%. The cut-off values for benign GB diseases were patient age <53.5 yrs, dotted intralesional vessels on CEUS and intact GB wall on CEUS.

Conclusion: CEUS is valuable in differentiating malignant from benign GB diseases. Branched or linear intralesional vessels and destruction of GB wall on CEUS are the CEUS features highly suggestive of GB malignancy and the patient age >53.5 yrs is also a clue for GB malignancy.

语种英语
WOS记录号WOS:000310600500115
项目编号2008-2-10 ; 20114003
资助机构Chinese Ministry of Health ; Shanghai Health Bureau
引用统计
被引频次:28[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64518
专题北京大学临床肿瘤学院_超声科
作者单位1.Tongji Univ, Peoples Hosp 10, Dept Med Ultrasound, Shanghai 200092, Peoples R China
2.Sun Yat Sen Univ, Affiliated Hosp 1, Dept Med Ultrason, Guangzhou 510275, Guangdong, Peoples R China
3.Fudan Univ, Zhongshan Hosp, Dept Ultrasound, Shanghai 200433, Peoples R China
4.Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Ultrasound Med, Shanghai 200030, Peoples R China
5.Peking Univ, Sch Oncol, Beijing Canc Inst, Dept Ultrasound, Beijing 100871, Peoples R China
6.China Med Univ, Shengjing Hosp, Dept Ultrasound, Shenyang, Peoples R China
7.Capital Med Univ, Beijing Friendship Hosp, Dept Ultrasound, Beijing, Peoples R China
8.Sun Yat Sen Univ, Affiliated Hosp 2, Dept Ultrasound, Guangzhou 510275, Guangdong, Peoples R China
9.Sun Yat Sen Univ, Affiliated Hosp 6, Dept Ultrasound, Guangzhou 510275, Guangdong, Peoples R China
推荐引用方式
GB/T 7714
Liu, Lin-Na,Xu, Hui-Xiong,Lu, Ming-De,et al. Contrast-Enhanced Ultrasound in the Diagnosis of Gallbladder Diseases: A Multi-Center Experience[J]. PLOS ONE,2012,7(10).
APA Liu, Lin-Na.,Xu, Hui-Xiong.,Lu, Ming-De.,Xie, Xiao-Yan.,Wang, Wen-Ping.,...&Wen, Yan-Ling.(2012).Contrast-Enhanced Ultrasound in the Diagnosis of Gallbladder Diseases: A Multi-Center Experience.PLOS ONE,7(10).
MLA Liu, Lin-Na,et al."Contrast-Enhanced Ultrasound in the Diagnosis of Gallbladder Diseases: A Multi-Center Experience".PLOS ONE 7.10(2012).
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Liu, Lin-Na]的文章
[Xu, Hui-Xiong]的文章
[Lu, Ming-De]的文章
百度学术
百度学术中相似的文章
[Liu, Lin-Na]的文章
[Xu, Hui-Xiong]的文章
[Lu, Ming-De]的文章
必应学术
必应学术中相似的文章
[Liu, Lin-Na]的文章
[Xu, Hui-Xiong]的文章
[Lu, Ming-De]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。