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学科主题临床医学
Neuroprotective therapies for glaucoma
Song, Wei; Huang, Ping; Zhang, Chun
关键词glaucoma glaucomatous optic neuropathy retinal ganglion cells neuroprotection
刊名DRUG DESIGN DEVELOPMENT AND THERAPY
2015
DOI10.2147/DDDT.S80594
9页:1469-1479
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]RETINAL GANGLION-CELLS ; GINKGO-BILOBA EXTRACT ; NITRIC-OXIDE SYNTHASE ; OPTIC-NERVE HEAD ; HIGH INTRAOCULAR-PRESSURE ; NORMAL-TENSION GLAUCOMA ; OPEN-ANGLE GLAUCOMA ; DBA/2J MOUSE MODEL ; RAT MODEL ; VISUAL-FIELD
英文摘要

Glaucoma is the second leading cause for blindness worldwide. It is mainly caused by glaucomatous optic neuropathy (GON) characterized by retinal ganglion cell loss, which leads to visual field defect and blindness. Up to now, the main purpose of antiglaucomatous therapies has been to lower intraocular pressure (IOP) through surgeries and medications. However, it has been found that progressive GON is still present in some patients with effective IOP decrease. Therefore, risk factors other than IOP elevation, like neurotrophin deprivation and excitotoxicity, contribute to progressive GON. Novel approaches of neuroprotection may be more effective for preserving the function of the optic nerve.

语种英语
WOS记录号WOS:000350742100001
项目编号81300756 ; 7132219
资助机构Chinese State Natural and Science Foundation ; Beijing Natural Science Foundation
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64520
专题北京大学第三临床医学院_眼科
北京大学第三临床医学院_骨科
北京大学第三临床医学院_护理部
作者单位Peking Univ, Hosp 3, Dept Ophthalmol, Beijing 100191, Peoples R China
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Song, Wei,Huang, Ping,Zhang, Chun. Neuroprotective therapies for glaucoma[J]. DRUG DESIGN DEVELOPMENT AND THERAPY,2015,9:1469-1479.
APA Song, Wei,Huang, Ping,&Zhang, Chun.(2015).Neuroprotective therapies for glaucoma.DRUG DESIGN DEVELOPMENT AND THERAPY,9,1469-1479.
MLA Song, Wei,et al."Neuroprotective therapies for glaucoma".DRUG DESIGN DEVELOPMENT AND THERAPY 9(2015):1469-1479.
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