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学科主题: 临床医学
题名:
Neuroprotective therapies for glaucoma
作者: Song, Wei; Huang, Ping; Zhang, Chun
关键词: glaucoma ; glaucomatous optic neuropathy ; retinal ganglion cells ; neuroprotection
刊名: DRUG DESIGN DEVELOPMENT AND THERAPY
发表日期: 2015
DOI: 10.2147/DDDT.S80594
卷: 9, 页:1469-1479
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: RETINAL GANGLION-CELLS ; GINKGO-BILOBA EXTRACT ; NITRIC-OXIDE SYNTHASE ; OPTIC-NERVE HEAD ; HIGH INTRAOCULAR-PRESSURE ; NORMAL-TENSION GLAUCOMA ; OPEN-ANGLE GLAUCOMA ; DBA/2J MOUSE MODEL ; RAT MODEL ; VISUAL-FIELD
英文摘要:

Glaucoma is the second leading cause for blindness worldwide. It is mainly caused by glaucomatous optic neuropathy (GON) characterized by retinal ganglion cell loss, which leads to visual field defect and blindness. Up to now, the main purpose of antiglaucomatous therapies has been to lower intraocular pressure (IOP) through surgeries and medications. However, it has been found that progressive GON is still present in some patients with effective IOP decrease. Therefore, risk factors other than IOP elevation, like neurotrophin deprivation and excitotoxicity, contribute to progressive GON. Novel approaches of neuroprotection may be more effective for preserving the function of the optic nerve.

语种: 英语
所属项目编号: 81300756 ; 7132219
项目资助者: Chinese State Natural and Science Foundation ; Beijing Natural Science Foundation
WOS记录号: WOS:000350742100001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64520
Appears in Collections:北京大学第三临床医学院_眼科_期刊论文

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作者单位: Peking Univ, Hosp 3, Dept Ophthalmol, Beijing 100191, Peoples R China

Recommended Citation:
Song, Wei,Huang, Ping,Zhang, Chun. Neuroprotective therapies for glaucoma[J]. DRUG DESIGN DEVELOPMENT AND THERAPY,2015,9:1469-1479.
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