IR@PKUHSC  > 北京大学第一临床医学院  > 心血管内科
学科主题临床医学
Protective effects of ghrelin on ischemia/reperfusion injury in the isolated rat heart
Chang, L; Ren, YS; Liu, XH; Li, WG; Yang, JH; Geng, B; Weintraub, NL; Tang, CS
关键词ghrelin ghrelin receptor heart ischemia/reperfusion
刊名JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
2004-02-01
43期:2页:165-170
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cardiac & Cardiovascular Systems ; Pharmacology & Pharmacy
研究领域[WOS]Cardiovascular System & Cardiology ; Pharmacology & Pharmacy
关键词[WOS]CACHEXIA ; BINDING ; HUMANS
英文摘要

Ghrelin, an endogenous ligand of the growth hormone secretagogue receptor, has been reported to have beneficial effects on cardiac function. The authors used the Langendorff model of ischemia/reperfusion (I/R) injury in isolated rat heart to determine whether ghrelin exerts direct cardioprotective effects. Also, the capacity of ghrelin to bind to sarcolemmal membrane fractions before and after ischemia and reperfusion was examined. Compared with vehicle administration, administration of ghrelin (100-10,000 pM) during the reperfusion period resulted in improvement in coronary flow, heart rate, left ventricular systolic pressure, and left ventricular end-diastolic pressure. Ghrelin also enhanced the rates of left ventricular contraction and relaxation after ischemia following reperfusion. Administration of ghrelin during reperfusion reduced myocardial release of lactate debydrogenase and myoglobin, indicating protection against cardiomyocyte injury. In addition, ghrelin attenuated the depletion of myocardial ATP resulting from ischemia and reperfusion. A receptor-binding assay demonstrated that maximum binding capacity of ghrelin to sarcolemmal membranes was significantly increased after ischemia and was further increased after I/R. However, Scatchard analysis showed that the affinity of ghrelin for its receptor was not altered. The authors have concluded that administration of ghrelin during reperfusion protects against myocardial I/R injury. The cardioprotective effects are independent of growth hormone release and likely involve binding to cardiovascular receptors, a process that is upregulated during I/R.

语种英语
WOS记录号WOS:000188428200001
Citation statistics
Cited Times:114[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64528
Collection北京大学第一临床医学院_心血管内科
作者单位1.Univ Iowa, Coll Med, Dept Internal Med, Iowa City, IA USA
2.Peking Univ, Hosp 1, Inst Cardiovasc Dis Res, Beijing 100871, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Physiol, Beijing 100871, Peoples R China
4.Univ Iowa, Coll Med, Free Rad & Radiat Biol Program, Iowa City, IA USA
Recommended Citation
GB/T 7714
Chang, L,Ren, YS,Liu, XH,et al. Protective effects of ghrelin on ischemia/reperfusion injury in the isolated rat heart[J]. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY,2004,43(2):165-170.
APA Chang, L.,Ren, YS.,Liu, XH.,Li, WG.,Yang, JH.,...&Tang, CS.(2004).Protective effects of ghrelin on ischemia/reperfusion injury in the isolated rat heart.JOURNAL OF CARDIOVASCULAR PHARMACOLOGY,43(2),165-170.
MLA Chang, L,et al."Protective effects of ghrelin on ischemia/reperfusion injury in the isolated rat heart".JOURNAL OF CARDIOVASCULAR PHARMACOLOGY 43.2(2004):165-170.
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