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Video-assisted thoracoscopic surgery is more favorable than thoracotomy for administration of adjuvant chemotherapy after lobectomy for non-small cell lung cancer
Jiang, Guanchao; Yang, Fan; Li, Xiao; Liu, Jun; Li, Jianfeng; Zhao, Hui; Li, Yun; Wang, Jun
关键词video-assisted thoracoscopic surgery (VATS) lobectomy non-small cell lung cancer (NSCLC) adjuvant chemotherapy
刊名WORLD JOURNAL OF SURGICAL ONCOLOGY
2011-12-21
DOI10.1186/1477-7819-9-170
9
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Surgery
研究领域[WOS]Oncology ; Surgery
关键词[WOS]VINORELBINE PLUS CISPLATIN ; TRIAL ; EXPERIENCE ; MUTATIONS ; SAFETY ; PAIN ; VATS
英文摘要

Background: Video-assisted thoracoscopic surgery (VATS) lobectomy is a newly developed type of surgery for lung cancer and has been demonstrated obvious minimally-invasive advantages compared with traditional thoracotomy. Theoretically, that less trauma leads to quicker recovery and may facilitate administration of adjuvant chemotherapy. We tested this hypothesis in this study.

Methods: One hundred and ten NSCLC patients underwent lobectomy and adjuvant chemotherapy from June 2004 to June 2010 was analyzed. The baseline characteristic criteria, variables related to surgery and accomplishing status of chemotherapy were analyzed.

Results: All 110 patients underwent lobectomy through VATS (n = 54) or thracotomy (n = 56) and adjuvant chemotherapy. There was no significant difference in patients′ age, preoperative pulmonary function, co-morbidity, pathologic staging between the two groups, whereas, blood loss, operation time and postoperative complications, chest tube duration and length of stay were less in VATS group. There were no significant differences in time to initiation chemotherapy. Cases in VATS group received more cycles of chemotherapy (3.6 vs. 3.0, p = 0.002). A higher proportion of patients received full dose on schedule in VATS group (57.4% vs. 33.9%, p = 0.013) and a higher proportion of patients completed >= 75% planed dose, (88.9% vs. 71.4%, p = 0.022); slightly higher proportion of patients in thoracotomy group had grade 3 or more toxicity (20.4% vs. 35.7%, p = 0.074).

Conclusions: Patients underwent lobectomy by VATS have better compliance and fewer delayed or reduced dose on adjuvant chemotherapy than those by thoracotomy.

语种英语
WOS记录号WOS:000299256100001
引用统计
被引频次:19[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/64530
专题北京大学第二临床医学院_胸外科
作者单位Peking Univ, Peoples Hosp, Dept Thorac Surg, Ctr Miniinvas Thorac Surg, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Jiang, Guanchao,Yang, Fan,Li, Xiao,et al. Video-assisted thoracoscopic surgery is more favorable than thoracotomy for administration of adjuvant chemotherapy after lobectomy for non-small cell lung cancer[J]. WORLD JOURNAL OF SURGICAL ONCOLOGY,2011,9.
APA Jiang, Guanchao.,Yang, Fan.,Li, Xiao.,Liu, Jun.,Li, Jianfeng.,...&Wang, Jun.(2011).Video-assisted thoracoscopic surgery is more favorable than thoracotomy for administration of adjuvant chemotherapy after lobectomy for non-small cell lung cancer.WORLD JOURNAL OF SURGICAL ONCOLOGY,9.
MLA Jiang, Guanchao,et al."Video-assisted thoracoscopic surgery is more favorable than thoracotomy for administration of adjuvant chemotherapy after lobectomy for non-small cell lung cancer".WORLD JOURNAL OF SURGICAL ONCOLOGY 9(2011).
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