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学科主题: 临床医学
题名:
Video-assisted thoracoscopic surgery is more favorable than thoracotomy for administration of adjuvant chemotherapy after lobectomy for non-small cell lung cancer
作者: Jiang, Guanchao; Yang, Fan; Li, Xiao; Liu, Jun; Li, Jianfeng; Zhao, Hui; Li, Yun; Wang, Jun
关键词: video-assisted thoracoscopic surgery (VATS) ; lobectomy ; non-small cell lung cancer (NSCLC) ; adjuvant chemotherapy
刊名: WORLD JOURNAL OF SURGICAL ONCOLOGY
发表日期: 2011-12-21
DOI: 10.1186/1477-7819-9-170
卷: 9
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Surgery
研究领域[WOS]: Oncology ; Surgery
关键词[WOS]: VINORELBINE PLUS CISPLATIN ; TRIAL ; EXPERIENCE ; MUTATIONS ; SAFETY ; PAIN ; VATS
英文摘要:

Background: Video-assisted thoracoscopic surgery (VATS) lobectomy is a newly developed type of surgery for lung cancer and has been demonstrated obvious minimally-invasive advantages compared with traditional thoracotomy. Theoretically, that less trauma leads to quicker recovery and may facilitate administration of adjuvant chemotherapy. We tested this hypothesis in this study.

Methods: One hundred and ten NSCLC patients underwent lobectomy and adjuvant chemotherapy from June 2004 to June 2010 was analyzed. The baseline characteristic criteria, variables related to surgery and accomplishing status of chemotherapy were analyzed.

Results: All 110 patients underwent lobectomy through VATS (n = 54) or thracotomy (n = 56) and adjuvant chemotherapy. There was no significant difference in patients′ age, preoperative pulmonary function, co-morbidity, pathologic staging between the two groups, whereas, blood loss, operation time and postoperative complications, chest tube duration and length of stay were less in VATS group. There were no significant differences in time to initiation chemotherapy. Cases in VATS group received more cycles of chemotherapy (3.6 vs. 3.0, p = 0.002). A higher proportion of patients received full dose on schedule in VATS group (57.4% vs. 33.9%, p = 0.013) and a higher proportion of patients completed >= 75% planed dose, (88.9% vs. 71.4%, p = 0.022); slightly higher proportion of patients in thoracotomy group had grade 3 or more toxicity (20.4% vs. 35.7%, p = 0.074).

Conclusions: Patients underwent lobectomy by VATS have better compliance and fewer delayed or reduced dose on adjuvant chemotherapy than those by thoracotomy.

语种: 英语
项目资助者: Ministry of Health of P.R. China ; Capital Medical Development Fund
WOS记录号: WOS:000299256100001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/64530
Appears in Collections:北京大学第二临床医学院_胸外科_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Dept Thorac Surg, Ctr Miniinvas Thorac Surg, Beijing 100044, Peoples R China

Recommended Citation:
Jiang, Guanchao,Yang, Fan,Li, Xiao,et al. Video-assisted thoracoscopic surgery is more favorable than thoracotomy for administration of adjuvant chemotherapy after lobectomy for non-small cell lung cancer[J]. WORLD JOURNAL OF SURGICAL ONCOLOGY,2011,9.
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